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4-Methoxyacetoacetanilide

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Identification
Molecular formula
C11H13NO3
CAS number
556-95-0
IUPAC name
N-(4-methoxyphenyl)-3-oxo-butanamide
State
State

At room temperature, 4-Methoxyacetoacetanilide is in a solid state. Its crystalline nature allows it to remain stable under standard laboratory conditions.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.00
Boiling point (Celsius)
382.85
Boiling point (Kelvin)
655.85
General information
Molecular weight
193.20g/mol
Molar mass
193.2040g/mol
Density
1.1730g/cm3
Appearence

4-Methoxyacetoacetanilide typically appears as a white to off-white crystalline powder. Its crystals are often needle-like, and it is known to have a linear structure due to its amide linkage.

Comment on solubility

Solubility of N-(4-methoxyphenyl)-3-oxo-butanamide

N-(4-methoxyphenyl)-3-oxo-butanamide, with its unique chemical structure, exhibits distinctive solubility properties that can influence its behavior in various environments. The solubility of this compound is primarily affected by the following factors:

  • Polarity: The presence of the 4-methoxyphenyl moiety contributes to polarity, which often increases solubility in polar solvents.
  • Hydrogen Bonding: The amide functional group can engage in hydrogen bonding with water, enhancing solubility in aqueous environments.
  • Solvent Compatibility: It is likely to have good solubility in organic solvents such as ethanol and acetone, while exhibiting lower solubility in non-polar solvents.

In general, compounds with amide functionalities are known for their moderate to high solubility in water, particularly when accompanied by polar substituents. As a result, one might anticipate that N-(4-methoxyphenyl)-3-oxo-butanamide's solubility will be favorable under certain conditions, making it potentially useful in various applications.

In summary, the solubility of N-(4-methoxyphenyl)-3-oxo-butanamide can be characterized by:

  1. Good solubility in polar solvents
  2. Enhanced solubility due to hydrogen bonding
  3. Potential issues with solubility in apolar environments

Understanding these solubility characteristics is crucial for optimizing its usage in both research and industrial applications.

Interesting facts

Interesting Facts About N-(4-methoxyphenyl)-3-oxo-butanamide

N-(4-methoxyphenyl)-3-oxo-butanamide is a fascinating compound known for its diverse applications in various fields, particularly in medicinal chemistry. Here are some captivating points about this compound:

  • Structural Insight: The presence of the methoxy group attached to the phenyl ring contributes to the compound's unique chemical behavior, influencing its reactivity and solubility in organic solvents.
  • Biological Activity: Compounds like N-(4-methoxyphenyl)-3-oxo-butanamide have shown potential in pharmaceutical research. Many such amides are being investigated for their anti-inflammatory and analgesic properties.
  • Synthesis: The synthesis of this compound often involves multiple steps, typically starting from readily available precursors. The reaction conditions and catalysts play a crucial role in determining the success and efficiency of the synthesis process.
  • Importance in Drug Development: The analogs of this compound are of interest in the search for new therapeutic agents. Their ability to modulate biological pathways makes them valuable in drug design.
  • Research Applications: Due to its structural features, this compound is often utilized as a building block in the development of more complex molecules in organic synthesis.

Quotes from chemists often highlight the balance of structure and function: “Understanding a compound’s structure can unveil its potential—N-(4-methoxyphenyl)-3-oxo-butanamide is a testament to this notion.”

Overall, N-(4-methoxyphenyl)-3-oxo-butanamide represents a significant focal point in contemporary chemical research, showcasing the intricate relationship between compound structure and biological activity.

Synonyms
N-(4-Methoxyphenyl)-3-oxobutanamide
4'-Methoxyacetoacetanilide
p-ACETOACETANISIDIDE
Butanamide, N-(4-methoxyphenyl)-3-oxo-
Acetoacet-p-anisidide
p-Acetoacetanisidine
para-Acetoacetanisidide
N-(4-Methoxyphenyl)acetoacetamide
Acetoacetanilide, 4'-methoxy-
NSC 16508
Butanamide, N-(4-methoxyphenyl)-oxo-
NSC 116392
NSC 216130
p-Methoxyacetoacetanilide
EINECS 226-615-6
UNII-YCG3918U16
BRN 2213866
DTXSID7044689
AI3-52429
YCG3918U16
N-(4-Methoxyphenyl)acetylacetamide
NSC-16508
NSC-116392
NSC-216130
DTXCID5024689
EC 226-615-6
ACETOACETIC ACID P-ANISIDIDE
N-(4-Methoxy-phenyl)-3-oxo-butyramide
Butanamide, 3-oxo-N-(4-methoxyphenyl)-
226-615-6
4-13-00-01229 (beilstein handbook reference)
swajjkrocojicg-uhfffaoysa-n
5437-98-9
N-(4-methoxyphenyl)-3-oxo-butyramide
p-Acetoacetaniside
MFCD00008783
Maybridge1_001183
N-Acetoacetyl-p-anisidine
4\'-Methoxyacetoacetanilide
N-Acetoacetyl-4-methoxyaniline
SCHEMBL1117828
CHEMBL3185475
HMS544N17
NSC16508
Tox21_301481
CCG-52405
NSC116392
NSC216130
STK397314
AKOS000120070
DS-1122
N-(4-Methoxyphenyl)-3-oxobutanamide #
NCGC00256049-01
CAS-5437-98-9
DB-013367
A1307
CS-0155065
NS00005091
EN300-17092
D70282
N~1~-(4-METHOXYPHENYL)-3-OXOBUTANAMIDE
10D-068
SR-01000641644-1
Q27294450
Z56876415
F6660-3676