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4'-Nitroacetanilide

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Identification
Molecular formula
C8H8N2O3
CAS number
104-04-1
IUPAC name
N-(4-nitrophenyl)acetamide
State
State

At room temperature, 4'-Nitroacetanilide is a solid substance. It remains solid under typical atmospheric conditions and does not transition into a liquid or gaseous state unless heated beyond its melting or boiling points. This solid state is robust due to the regularity and strength of intermolecular forces, specifically hydrogen bonding and van der Waals forces, within its crystalline structure.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
328.00
Boiling point (Kelvin)
601.15
General information
Molecular weight
180.16g/mol
Molar mass
180.1570g/mol
Density
1.4045g/cm3
Appearence

This compound typically presents as yellowish crystals or a crystalline powder. Its color comes from the nitro group, which often imparts a pale to vivid yellow hue depending on the substance concentration and lighting conditions. It's generally solid and brittle in its natural state, with a characteristic crystalline structure.

Comment on solubility

Solubility of N-(4-nitrophenyl)acetamide

N-(4-nitrophenyl)acetamide is known for its interesting solubility profile, which is significantly influenced by its chemical structure. This compound exhibits the following characteristics regarding solubility:

  • Solvent Interaction: N-(4-nitrophenyl)acetamide tends to dissolve well in polar solvents, such as water and ethanol, due to the presence of the acetamide functional group.
  • Limited Solubility in Non-Polar Solvents: Conversely, this compound shows poor solubility in non-polar solvents like hexane or benzene, highlighting the impact of polarity on its solubility.
  • Temperature Sensitivity: The solubility may also vary with temperature; generally, an increase in temperature can enhance solubility for some ionic or polar compounds.
  • pH Dependence: The solubility can be affected by pH levels, especially if ionizable groups are present. However, in contrast, N-(4-nitrophenyl)acetamide is relatively stable across a range of pH levels, maintaining a consistent degree of solubility.

Overall, the solubility behavior of N-(4-nitrophenyl)acetamide illustrates the significant role that both molecular structure and solvent polarity play in determining how well this compound can dissolve.

Interesting facts

Interesting Facts About N-(4-nitrophenyl)acetamide

N-(4-nitrophenyl)acetamide is a fascinating compound due to its unique properties and diverse applications. Here are some intriguing aspects that highlight its significance in both chemical research and industry:

  • Chemical Structure: This compound contains a nitro group, which is a powerful electron-withdrawing group, influencing its reactivity and chemical behavior. The presence of the acetamide moiety contributes to its characteristic functional properties.
  • Applications in Synthesis: N-(4-nitrophenyl)acetamide is often utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its ability to form derivatives makes it a valuable compound in synthetic chemistry.
  • Biological Activity: This compound has been studied for its potential biological activities, including antimicrobial and antitumor properties. Research continues to explore its mechanism of action and efficacy in medicinal chemistry.
  • Analytical Chemistry: N-(4-nitrophenyl)acetamide can be used as a reactant in various analytical techniques, contributing to the detection and quantification of other compounds through colorimetric or spectrophotometric methods.

As with many nitro compounds, its chemistry reflects an exciting interplay between structure and function. Understanding compounds like N-(4-nitrophenyl)acetamide not only broadens our knowledge of organic chemistry but also opens avenues for innovation in product development.

In the words of renowned chemist Linus Pauling: "It is the responsibility of the scientist to understand their influence on the world." This highlights the importance of studying compounds such as N-(4-nitrophenyl)acetamide and their impact on society.

Synonyms
N-(4-Nitrophenyl)acetamide
4'-Nitroacetanilide
104-04-1
4-NITROACETANILIDE
P-Nitroacetanilide
N-Acetyl-4-nitroaniline
p-Acetamidonitrobenzene
p-Nitrophenylacetanilide
N-Acetyl-p-nitroaniline
Acetamide, N-(4-nitrophenyl)-
Acetanilide, p-nitro-
Acetanilide, 4'-nitro-
NSC 1315
CCRIS 5566
Acetic acid 4-nitroanilide
EINECS 203-169-0
AI3-01545
NSC-1315
MFCD00007303
PH3B066365
N-(4-Nitro-phenyl)-acetamide
P-NITROACETANILIDE [MI]
DTXSID5059290
UNII-PH3B066365
p-acetamino nitrobenzene
Maybridge1_001346
WLN: WNR DMV1
4-Nitroacetanilide, 98%
N-(p-Nitrophenyl)acetamide
4-(Acetylamino)nitrobenzene
N-Acetyl-4-nitrobenzenamine
1-Nitro-4-acetylaminobenzene
4\'-NITROACETANILIDE
N-(4-nitrophenyl)-acetamide
SCHEMBL642700
Acetamide,N-(4-nitrophenyl)-
CHEMBL131469
Acetanilide, 4'-nitro-(8CI)
DTXCID3032838
HMS545F04
NSC1315
AB9858
STK004304
AKOS003237246
FN71072
SY106175
DB-040507
CS-0128761
N0108
NS00023276
10.14272/NQRLPDFELNCFHW-UHFFFAOYSA-N
7E-925
doi:10.14272/NQRLPDFELNCFHW-UHFFFAOYSA-N
Q7041448
N-ACETYL-4-NITROANILINE; Acetanilide,4'-nitro; 4'-Nitroacetanilide
203-169-0
VYZ