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N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide

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Identification
Molecular formula
C26H21N5O4
CAS number
.
IUPAC name
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
State
State

This compound is typically a solid at room temperature, maintaining its solid state unless subjected to temperatures approaching its melting point.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
515.55g/mol
Molar mass
515.5480g/mol
Density
1.2987g/cm3
Appearence

The compound typically appears as a pale yellow to off-white crystalline solid. Its appearance might vary slightly based on the specific conditions and presence of any impurities.

Comment on solubility

Solubility of N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide

The solubility of the compound N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide, with the chemical formula C26H21N5O4, can be influenced by several factors, including its molecular structure and functional groups. Understanding its solubility properties is critical for applications in pharmaceuticals and material sciences.

Key Factors Influencing Solubility:

  • Polarity: The presence of functional groups such as the amide and phenylbutoxy moiety can affect the overall polarity of the molecule, influencing its solubility in polar or non-polar solvents.
  • Hydrogen Bonding: The potential for intramolecular and intermolecular hydrogen bonding, especially due to the amide and tetrazole groups, can enhance solubility in polar solvents.
  • Crystallinity: The solid-state structure may also play a role; high crystallinity can restrict solubility, whereas more amorphous forms may dissolve more readily.

Generally, compounds that possess both hydrophilic and hydrophobic characteristics, like this one, may demonstrate variable solubility across different solvents:

  1. In water, the solubility might be low due to significant hydrophobic character.
  2. In organic solvents like DMSO or ethanol, the solubility could be enhanced owing to better interactions.
  3. Moreover, assessing pH can also be essential, as solubility might fluctuate with changes in acidity or basicity due to ionization of functional groups.

In conclusion, to fully comprehend the solubility of N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide, experimental determination under various conditions is highly recommended to ascertain its practical applications across different mediums.

Interesting facts

Interesting Facts About N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide

N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide is a fascinating chemical compound boasting a unique combination of structural features and potential applications. Here are some interesting insights:

  • Diverse Functional Groups: This compound contains a rich tapestry of functional groups, including a chromene unit, a tetrazole ring, and an amide. Each of these groups contributes to the compound's biological activity and chemical reactivity.
  • Biological Significance: Compounds similar to those in the benzamide family are often explored for their pharmaceuticals properties. Researchers are particularly interested in their role as potential anti-cancer and anti-inflammatory agents.
  • Versatile Applications: The presence of the tetrazole moiety indicates potential applications in drug discovery, especially in modifying pharmacokinetics and bioavailability of therapeutic agents.
  • Structure-Activity Relationship (SAR): Studying this compound can lead to valuable insights into how structural changes influence biological activity, guiding the design of more effective drugs.
  • Research Interest: Due to its complex structure, this compound is likely to attract interest in the field of medicinal chemistry, with ongoing studies focused on optimizing its effectiveness and reducing toxicity.

Overall, N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide exemplifies the intriguing interplay of structure and function that characterizes much of modern chemical research. As one researcher aptly put it, "The exploration of chemical compounds is like uncovering a treasure trove of possibilities."

Continuing research into such compounds not only enhances our understanding of their properties but also opens doors to innovative solutions in healthcare and beyond.

Synonyms
Pranlukast
103177-37-3
Azlaire
Ono-1078
ONO 1078
pranlukast hydrate
Pranlukast (INN)
Azlaire (TN)
SB 205312
CCN 00401
RS 411
ONO-RS 411
Pranlukast [INN:BAN]
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Onon
DTXSID3043782
UNII-TB8Z891092
Ono-RS-411
PRANLUKAST [MI]
4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran
PRANLUKAST [INN]
N-(4-OXO-2-(1H-TETRAZOL-5-YL)-4H-CHROMEN-8-YL)-4-(4-PHENYLBUTOXY)BENZAMIDE
CCN-00401
RS-411
TB8Z891092
PRANLUKAST [MART.]
PRANLUKAST [WHO-DD]
CHEMBL21333
SB-205312
ONO RS-411
DTXCID1023782
NCGC00181765-01
PRANLUKAST (MART.)
N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-p-(4-phenylbutoxy)benzamide
n-[4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide
Benzamide, N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)-
BENZAMIDE, N-(4-OXO-2-(2H-TETRAZOL-5-YL)-4H-1-BENZOPYRAN-8-YL)-4-(4-PHENYLBUTOXY)-
N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide
8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-P-(4-phenylbutoxy)benzamide;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-P-(4-phenylbutoxy)benzamide
SR-05000001474
pranlukastum
N-(4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl)-4-(4-phenylbutoxy)benzamide
N-(4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide
N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Pranlukast (Standard)
SCHEMBL3693
MLS006010078
GTPL3634
SCHEMBL18058592
CHEBI:94810
HY-B0290R
R03DC02
HMS2089H16
HMS3650A14
HMS3714E03
BCP04577
HY-B0290
Tox21_112952
AC-696
BDBM50023198
MFCD00864631
MFCD24539454
AKOS015967342
103177-37-3 (anhyd.)
CCG-220661
DB01411
FP27120
SB19080
8-(4 (4-phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)-4-oxo-4H-1-benzopyran
N-(4-oxo-2-(2H-tetrazol-5-yl)-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide
AS-15105
DA-77034
SMR004701229
CAS-103177-37-3
NS00068609
P2115
C71133
D08408
AB01275471-01
L013134
Q7238392
SR-05000001474-1
SR-05000001474-2
SR-05000001474-3
BRD-K97045029-001-01-9
BRD-K97045029-001-02-7
BRD-K97045029-001-04-3
8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5-yl)-4-oxo-4H-1-benzopyran
N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide
N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide
808-178-9
KNT
N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide (ONO-RS-411)
N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenyl-butoxy)-benzamide(ONO-RS-411)
N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide;ONO-1078;ONO-RS-411