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Glyphosate

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Identification
Molecular formula
C3H8NO5P
CAS number
1071-83-6
IUPAC name
N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine
State
State

At room temperature, glyphosate is primarily found in a solid state. In various formulations, it might be mixed with other compounds but remains stable and solid under standard conditions. When used in agriculture, it is commonly diluted in water to form an aqueous solution for spraying.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
169.07g/mol
Molar mass
169.0730g/mol
Density
1.7400g/cm3
Appearence

Glyphosate, as its potassium salt, usually appears as a white solid with no significant odor. It is typically encountered in the form of an off-white powder or as colorless crystals when purified. Commercial formulations may vary in color due to the presence of other ingredients but generally maintain a similar appearance.

Comment on solubility

Solubility of N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine

N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine is a complex compound whose solubility can be influenced by various factors. Understanding its solubility characteristics is crucial for applications in both laboratory and industrial settings. Here are some key points regarding its solubility:

  • Solvent Interaction: This compound is likely to demonstrate varying solubility in different solvents due to the presence of polar and nonpolar functional groups. For example, it may be more soluble in polar solvents like water or methanol due to hydrogen bonding.
  • Temperature Effects: As with many chemical compounds, solubility may increase with temperature. This effect can be particularly significant for organic compounds, which may dissolve better in warmer conditions.
  • pH Dependence: The solubility of this compound may also fluctuate with changes in pH owing to its basic amine group, which could become protonated under acidic conditions, affecting its solubility profile.
  • Hydrophobic Interactions: The 4-tert-butyl group introduces hydrophobic interactions, potentially reducing solubility in polar solvents, while enhancing it in nonpolar solvents such as hexane.

In conclusion, the solubility of N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine is a multifaceted topic influenced by solvent choice, temperature, pH levels, and the compound's structural features. Each of these factors plays a significant role, and understanding them can aid in optimizing the compound's use in various applications.

Interesting facts

Interesting Facts About N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine

N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine is a fascinating compound, particularly in the field of pharmaceutical science and environmental chemistry. Here are some key points that highlight its significance:

  • Dual Functionalities: This compound features both a phenoxy and phosphonyl group, which makes it a candidate for multi-functional applications in drug design, potentially leading to novel therapeutic agents.
  • Chlorine Influence: The presence of the chloro group enhances its effectiveness by increasing lipophilicity, allowing better absorption in biological systems, making it a subject of interest in medicinal chemistry.
  • Synthesis Challenges: The synthesis of this compound may involve complex reaction pathways, showcasing the importance of precision in organic synthesis and the clever application of reaction conditions.
  • Ecological Impact: Compounds like this one are often studied for their potential environmental impact, especially if they are found to exhibit pesticide-like activities or involved in organophosphate dynamics.
  • Applications Beyond Medicine: Aside from its potential medicinal applications, compounds of this class can also be explored for agricultural uses, particularly in developing safer agrochemicals.

In summary, N-[(4-tert-butyl-2-chloro-phenoxy)-methoxy-phosphoryl]methanamine is not just another organic compound; it is a testament to the intricate balance between chemistry and application. The ongoing research into such compounds continues to provide insights that can lead to innovative approaches in both human health and environmental preservation.

Synonyms
Crufomate
299-86-5
RUELENE
Amidofos
Amidophos
Montrel
Rulene
Ruelene drench
Dowco 132
Crufomate A
Crufomat
Crufomato
Ruelene 25E
Ruerene
Crufomate [ANSI]
Crufomatum
Cruformate
Caswell No. 263A
ENT 25,602-X
Crufomatum [INN-Latin]
Crufomato [INN-Spanish]
NSC 253463
Crufomate [USAN:INN:BAN]
4-tert-Butyl-2-chlorophenyl methyl methylphosphoramidate
HSDB 1547
EINECS 206-083-1
M-1261
4-tert-Butyl-2-chlorophenyl O-methyl methylphosphoroamidate
EPA Pesticide Chemical Code 012101
NSC-253463
BRN 2133258
N,O-Dimethyl-o-(4-tert-butyl-2-chlorophenyl)phosphoramidate
O-Methyl O-2-chloro-4-tert-butylphenyl N-methylamidophosphate
DTXSID1037515
4-t-Butyl-2-chlorophenyl methyl methylphosphoramidate
AI3-25602
O-(4-Terz.-butil-2-cloro-fenil)-O-metil-fosforammide
CRUFOMATE [INN]
CRUFOMATE [MI]
Phosphoramidic acid, methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester
CRUFOMATE [HSDB]
CRUFOMATE [USAN]
4-tert-Butyl-2-chlorophenyl N-methyl O-methylphosphoramidate
Methylphosphoramidic acid, 4-t-butyl-2-chlorophenyl methyl ester
Phosphoramidic acid, 4-tert-butyl-2-chlorophenylphosphoramidate
V82Q65924L
2-Chloro-4-(1,1-dimethylethyl)phenyl methyl methylphosphoramidate
O-(4-tert-Butyl-2-chlorophenyl) O-methyl N-methylamido phosphate
O-(4-tert Butyl-2-chloor-fenyl)-O-methyl-fosforzuur-N-methyl-amide
o-(4-tert-Butyl-2-chlor-phenyl)-O-methyl-phosphorsaeure-N-methylamid
Phenol, 4-t-butyl-2-chloro-, ester with methyl methylphosphoramidate
Phosphoramidic acid, methyl-, 4-tert-butyl-2-chlorophenyl methyl ester
4-t-Butyl-2-chlorophenylmethyl methyl phosphoramidate
DTXCID9017515
4-Tert. butyl 2-chlorophenyl methylphosphoramidate de methyle
CHEBI:82111
O-Methyl-O-(4-tert-butyl-2-chlorophenyl)methylphosphoramidate
O-(4-Terz.-butil-2-cloro-fenil)-O-metil-fosforammide [Italian]
4-06-00-03312 (Beilstein Handbook Reference)
4-Tert. butyl 2-chlorophenyl methylphosphoramidate de methyle [French]
Crufomate (ANSI)
Methylphosphoramidic acid 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester
O-(4-Tert butyl-2-chloor-fenyl)-O-methyl-fosforzuur-N-methyl-amide [Dutch]
O-(4-Tert-butyl-2-chlor-phenyl)-O-methyl-phosphorsaeure-N-methylamid [German]
Phosphoramidic acid methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester
Crufomatum (INN-Latin)
Crufomato (INN-Spanish)
Phosphorsaeure-methyl-(2-chlor-4-tert-butyl-phenyl)-diestermethylamid
4-(tert-butyl)-2-chlorophenyl methyl methylphosphoramidate
Methylphosphoramidic acid, 4-tert-butyl-2-chlorophenyl methyl ester
(RS)-(4-TERT-BUTYL-2-CHLOROPHENYL METHYL METHYLPHOSPHORAMIDATE)
O-(4-TERZ.-BUTIL-2-CLORO-FENIL)-O-METIL-FOSFORAMMIDE (ITALIAN)
UNII-V82Q65924L
4-TERT. BUTYL 2-CHLOROPHENYL METHYLPHOSPHORAMIDATE DE METHYLE (FRENCH)
O-(4-TERT BUTYL-2-CHLOOR-FENYL)-O-METHYL-FOSFORZUUR-N-METHYL-AMIDE (DUTCH)
O-(4-TERT-BUTYL-2-CHLOR-PHENYL)-O-METHYL-PHOSPHORSAEURE-N-METHYLAMID (GERMAN)
Crufomate (ACGIH)
N-[(4-tert-butyl-2-chlorophenoxy)-methoxyphosphoryl]methanamine
Crufomate (USAN/INN)
Methylphosphoramidic Acid 4-tert-Butyl-2-chlorophenyl Methyl Ester
DOWDO 132
SCHEMBL121165
CHEMBL1880767
4-tert-Butyl-2-chlorophenyl Methyl N-Methylphosphoramidate
Tox21_302262
NSC253463
AKOS015888331
NCGC00163827-01
NCGC00163827-02
NCGC00255615-01
CAS-299-86-5
O(4Terz.butil2clorofenil)Ometilfosforammide
NS00006383
Crufomate, PESTANAL(R), analytical standard
C18972
D03610
Phenol, ester with methyl methylphosphoramidate
4tButyl2chlorophenyl methyl methylphosphoramidate
4tButyl2chlorophenylmethyl methyl phosphoramidate
SR-01000945046
4tertButyl2chlorophenyl methyl methylphosphoramidate
N,ODimethylo(4tertbutyl2chlorophenyl)phosphoramidate
SR-01000945046-1
4tertButyl2chlorophenyl Nmethyl Omethylphosphoramidate
4tertButyl2chlorophenyl Omethyl methylphosphoroamidate
O(4Tert butyl2chloorfenyl)OmethylfosforzuurNmethylamide
OMethyl O2chloro4tertbutylphenyl Nmethylamidophosphate
OMethylO(4tertbutyl2chlorophenyl)methylphosphoramidate
Q20983235
WLN: 1X1 & 1 & R CG DOPO & O1 & M1
O(4tertButyl2chlorophenyl) Omethyl Nmethylamido phosphate
O(4Tertbutyl2chlorphenyl)OmethylphosphorsaeureNmethylamid
4-T-BUTYL-2-CHLOROPHENYLMETHYL METHYLPHOSPHORAMIDATE
4-tert-Butyl-2-chlorophenyl methyl methylamidophosphate #
4Tert. butyl 2chlorophenyl methylphosphoramidate de methyle
Methylphosphoramidic acid, 4tbutyl2chlorophenyl methyl ester
Phosphoramidic acid, 4tertbutyl2chlorophenylphosphoramidate
2Chloro4(1,1dimethylethyl)phenyl methyl methylphosphoramidate
Phenol, 4tbutyl2chloro, ester with methyl methylphosphoramidate
Phosphoramidic acid methyl-,1-dimethylethyl)phenyl methyl ester
Phosphoramidic acid, 4-tert-butyl-2-chlorophenyl methyl ester
[(4-tert-butyl-2-chlorophenoxy)(methoxy)phosphoryl](methyl)amine
Phosphoramidic acid, methyl, 4tertbutyl2chlorophenyl methyl ester
Methylphosphoramidic acid 2chloro4(1,1dimethylethyl)phenyl methyl ester
Phenol, 4-tert-butyl-2-chloro-, ester with methyl methylphosphoramidate
Phosphoramidic acid, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester
Phosphoramidic acid, methyl, 2chloro4(1,1dimethylethyl)phenyl methyl ester
phosphoramidic acid, methyl-, 2-chloro-4-(1,1-dimethylethyl), phenylmethyl ester
206-083-1