Pirfenidone | Solubility of Things

Identification

Molecular formula

C₁₂H₁₁NO₂

CAS number

53179-13-8

IUPAC name

N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide

State

At room temperature, Pirfenidone is in a solid state, specifically as a powder.

Melting point (Celsius)

109.00

Melting point (Kelvin)

382.15

Boiling point (Celsius)

312.00

Boiling point (Kelvin)

585.15

General information

Molecular weight

185.22g/mol

Molar mass

185.2230g/mol

Density

1.2863g/cm³

Appearence

Pirfenidone appears as a white to off-white crystalline powder. It is slightly soluble in water and soluble in ethanol and DMSO.

Comment on solubility

Solubility of N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide

N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide is a unique compound whose solubility can be quite interesting due to its chemical structure. Its solubility properties depend on various factors:

Polarity: This compound contains both polar and nonpolar functional groups, which may lead to moderate solubility in polar solvents such as water or methanol, while demonstrating improved solubility in nonpolar solvents like hexane or chloroform.
Temperature: The solubility often increases with rising temperature; thus, heating the solvent can enhance the dissolution of the compound.
pH Levels: The solubility may vary with changes in pH owing to the presence of the hydroxyl group, which can ionize under certain conditions, affecting overall solubility in aqueous solutions.
Crystal Structure: The crystalline nature of the compound can also play a significant role in its solubility rates; more amorphous forms typically dissolve faster.

In summary, the solubility of N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide is influenced by a combination of its structural characteristics and external conditions. As with many organic compounds, understanding its solubility behavior is crucial for applications in various chemical processes.

Interesting facts

Interesting Facts about N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide

N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide is a fascinating compound that has garnered attention in the fields of pharmacology and medicinal chemistry. Here are some compelling points:

Pharmacological Potential: This compound exhibits a variety of biological activities which have made it a target for drug development. It is especially noteworthy for its potential anti-inflammatory and analgesic properties.
Pyridine Ring Structure: The presence of a pyridine ring in its structure contributes to its unique chemical properties. Pyridine moieties are known for their ability to form hydrogen bonds, enhancing the compound's reactivity.
Intermolecular Interactions: Due to the presence of both hydroxyl and acetamide groups, this compound can engage in a range of intermolecular interactions such as hydrogen bonding, which influences its solubility and biological activity.
Applications in Research: Researchers are investigating N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide for potential roles in treating various conditions, including pain management and inflammation-related disorders.
Structure-Activity Relationship (SAR): Studies focusing on SAR have revealed that modifications to the substituents on the pyridine and phenyl rings can significantly affect the compound’s potency and selectivity.
Analytical Techniques: Characterization of this compound can be achieved through various techniques, including NMR, mass spectrometry, and high-performance liquid chromatography (HPLC), to confirm its purity and structural integrity.

As scientists continue to explore the capabilities of N-(4,6-dimethyl-2-pyridyl)-2-hydroxy-2-phenyl-acetamide, it broadens the understanding of how organic compounds can be modified for improved therapeutic outcomes.