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Galantamine

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Identification
Molecular formula
C17H21NO3
CAS number
1953-04-4
IUPAC name
N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide
State
State

At room temperature, galantamine is solid. It is stable under normal conditions and should be stored in a well-sealed container, protected from moisture and excessive heat.

Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
530.70
Boiling point (Kelvin)
803.85
General information
Molecular weight
287.35g/mol
Molar mass
287.3530g/mol
Density
1.3500g/cm3
Appearence

Galantamine is a white to almost white crystalline powder. It is typically odorless and often used in its hydrobromide salt form, which is also crystalline and can appear slightly off-white due to impurities or degradation over time.

Comment on solubility

Solubility of N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide

The solubility of N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide is a critical aspect to consider when evaluating its potential applications and behavior in various environments. This compound, with its complex structure, presents unique characteristics in terms of solubility.

Key points regarding the solubility of this compound include:

  • Polarity: The presence of multiple methoxy groups may contribute to increased polarity, enhancing solubility in polar solvents.
  • Hydrophobic regions: The hydrocarbon portions of the molecule could limit solubility in water, suggesting preferential solubility in organic solvents.
  • Temperature dependency: Solubility may vary significantly with temperature changes, and increased temperatures typically promote solubility for most organic compounds.
  • pH influence: The ionization of functional groups can also alter solubility, making pH an essential factor for its dissolution in aqueous solutions.

Overall, while the specific numerical values for its solubility may not be readily available, understanding the structural components can provide valuable insights into its solubility behavior.

Interesting facts

Interesting Facts About N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide

This fascinating compound is a part of a unique class of molecules, often referred to as isoquinolines. Isoquinoline structures are known for their diverse biological activities, especially in the field of medicinal chemistry.

Key Characteristics and Applications:

  • Bioactivity: Compounds with isoquinoline frameworks have been extensively studied for their potential therapeutic effects, including anti-cancer and anti-inflammatory properties.
  • Complexity: The intricate structure of this compound, featuring multiple stereocenters and functional groups, presents a challenge in synthesis but also highlights the vast potential for drug design.
  • Natural Products: Many isoquinoline derivatives are found in nature, particularly in various plants and fungi, where they play crucial roles as alkaloids.
  • Research Potential: Given its unique chemical structure, this compound could inspire further research in the development of new pharmaceuticals, particularly targeting diseases where traditional treatments have failed.

As a student or scientist delving into this compound, one might appreciate the following quote:

"The beauty of chemistry lies in its complexity and its ability to create wonders from simple elements."

In summary, N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide exemplifies the intersection of nature and innovation. Its structural intricacy and biological significance make it an exciting area for ongoing research and exploration in the world of chemistry.

Synonyms
19590-85-3
BENZAMIDE, N-(DECAHYDRO-2-METHYL-5-ISOQUINOLYL)-3,4,5-TRIMETHOXY-, cis-
N-[(4aR,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxybenzamide
DTXSID10941359
cis-N-(Decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxybenzamide
cis-5,9,10-H-5-(3,4,5-Trimethoxybenzamido)-2-methyldecahydroisoquinoline
3,4,5-Trimethoxy-N-(2-methyldecahydroisoquinolin-5-yl)benzene-1-carboximidic acid