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Galantamine

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Identification
Molecular formula
C17H21NO3
CAS number
1953-04-4
IUPAC name
N-[(4aS,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide
State
State

At room temperature, galantamine is typically in a solid state, specifically in the form of crystalline powder which is stable under standard conditions.

Melting point (Celsius)
126.50
Melting point (Kelvin)
399.70
Boiling point (Celsius)
523.10
Boiling point (Kelvin)
796.20
General information
Molecular weight
368.43g/mol
Molar mass
368.4310g/mol
Density
1.3471g/cm3
Appearence

Galantamine appears as a white to off-white crystalline powder. It is generally odorless and characterized by its fine particulate form, which allows for effective solubility.

Comment on solubility

Solubility of N-[(4aS,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide

The solubility of complex organic compounds such as N-[(4aS,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide can vary significantly based on several factors. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and materials science. Here are key points regarding its solubility:

  • Polarity: The presence of trimethoxy groups suggests a level of polarity, which may lead to enhanced solubility in polar solvents like methanol or ethanol.
  • Hydrophobic Regions: The octahydroisoquinoline structure can contribute to hydrophobic interactions, potentially making the compound less soluble in water but more soluble in non-polar solvents such as chloroform.
  • Functional Groups: The amide functional group can enhance solubility in polar solvents, indicating that some degree of solubility might be expected in aqueous environments, although it may not be complete.
  • Temperature Dependence: Solubility can also be influenced by temperature, often increasing at higher temperatures, which may lead to better dissolution in solvents.
  • pH Effects: Fluctuations in pH may alter the solubility of the compound, especially if it includes acidic or basic functional groups that can ionize.

In conclusion, while the exact solubility of this specific compound requires empirical testing, it is likely to exhibit variable solubility depending on the solvent and conditions employed. *Further studies are needed to ascertain its precise solubility profile, which is vital for practical applications.*

Interesting facts

Interesting Facts about N-[(4aS,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxy-benzamide

This compound is a fascinating example of the rich diversity found in organic chemistry, particularly in the realm of pharmaceutical research. It belongs to a class of compounds known for their potential biological activities. Here are some intriguing aspects to consider:

  • Structural Complexity: The compound features a unique octahydro-1H-isoquinoline core, which contributes to its structural complexity and potential interactions within biological systems.
  • Bioactivity: Its distinctive structure suggests possible effects on the central nervous system, making it a candidate for further studies in neuropharmacology.
  • Mechanism of Action: Compounds such as this one may interact with various neurotransmitters, providing opportunities for therapeutic applications in areas like mood disorders or pain management.
  • Synthetic Pathways: The synthesis of this compound can involve sophisticated organic chemistry techniques, highlighting the importance of innovation in creating new pharmaceuticals.
  • Future Research: Ongoing research may uncover additional properties or uses for this compound, especially in medicinal chemistry, where novel compounds are continually sought for drug development.

As a student of chemistry, you might appreciate the intricacies involved in determining the stereochemistry and reactivity of such complex molecules. The potential for this compound to lead to breakthroughs in the field illustrates how the microscopic world of molecules can have profound implications in health and medicine.

In summary, this compound encapsulates the essence of chemical exploration, where each discovery opens doors to new scientific inquiries and applications.

Synonyms
27460-73-7
BENZAMIDE, N-(DECAHYDRO-2-METHYL-5-ISOQUINOLYL)-3,4,5-TRIMETHOXY-, trans-
RefChem:1078106
N-[(4aS,8aR)-2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-5-yl]-3,4,5-trimethoxybenzamide
5-(3,4,5-Trimethoxybenzamido)-2-methyl-trans-decahydroisoquinoline
trans-N-(2-Methyldecahydroisoquinol-5-yl)-3,4,5-trimethoxybenzamide
trans-N-(Decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxybenzamide
Benzamide, N-(2-methyldecahydroisoquinol-5-yl)-3,4,5-trimethoxy-, (E)-
trans-9,10-t-5-H-5-(3,4,5-Trimethoxybenzamido)-2-methyldecahydroisoquinoline