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N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide

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Identification
Molecular formula
C13H15N3O4S
CAS number
113415-29-7
IUPAC name
N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
State
State
The compound is typically found as a solid at room temperature.
Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
291.80
Boiling point (Kelvin)
564.95
General information
Molecular weight
310.35g/mol
Molar mass
310.3520g/mol
Density
1.3387g/cm3
Appearence

The compound appears as a white to off-white solid powder.

Comment on solubility

Solubility of N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide

N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide is a fascinating compound with unique solubility characteristics. Understanding its solubility can provide insight into its potential applications and behavior in different environments. Here are some key points regarding its solubility:

  • Polar and Non-Polar Interactions: The presence of both a sulfonamide group and a pyrimidine ring indicates that the compound may exhibit polar interactions due to the sulfonyl functional group, while the aromatic and ether moieties can contribute to non-polar characteristics.
  • Solvent Compatibility: This compound is likely to be more soluble in polar solvents such as water and dimethyl sulfoxide (DMSO), while potentially showing lower solubility in non-polar solvents.
  • Temperature Dependence: As with many compounds, solubility may be temperature-dependent. Increased temperature can facilitate solubility by promoting the dissolution process.
  • pH Sensitivity: The solubility of sulfonamides can be influenced by the pH of the solution, with different solubility profiles in acidic versus basic environments.

In summary, the solubility of N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide reflects its structural features, suggesting it may favor polar solvents and display variability based on factors like temperature and pH. Knowledge of these solubility traits can assist chemists in leveraging this compound for various experimental and practical purposes.

Interesting facts

Interesting Facts about N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide

N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide is a fascinating compound with various promising applications, particularly in the field of pharmaceutical chemistry. Here are some intriguing points about this compound:

  • Targeting Specific Pathways: This compound has been studied for its ability to inhibit certain biological pathways, making it a potential candidate in drug development. Particularly, compounds like this one can play a key role in anti-cancer therapies.
  • Structural Diversity: The unique combination of a pyrimidine ring with a sulfonamide group offers a plethora of possibilities for modifying and improving its properties. This structural diversity allows scientists to tailor compounds to enhance their effectiveness and reduce side effects.
  • Mechanism of Action: The sulfonamide moiety is known for its ability to mimic para-aminobenzoic acid (PABA), a substrate required for the synthesis of folate. This mechanism is crucial in disrupting bacterial growth and metabolism.
  • Versatile Applications: Beyond its potential usage in pharmaceuticals, derivatives of sulfonamides have also found uses in agricultural chemistry and materials science, illustrating the versatility of this compound class.
  • Innovative Research: Ongoing studies are exploring the synthesis and reactivity of similar compounds, contributing to a deeper understanding of their mechanisms and paving the way for new therapeutic strategies.

"In the quest for new therapeutic agents, the exploration of compounds like N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide serves as a reminder of the intricate dance between structure and activity in medicinal chemistry."

This compound exemplifies the importance of investigating molecular structures that combine different functional groups, leading to enhanced biological activity and multifaceted applications. Researchers are continually unlocking the potential of such compounds, making them indispensable in the journey towards innovative solutions in medicine and beyond.

Synonyms
GLYMIDINE
Glycodiazine
Glidiazine
339-44-6
Glymidinum
Glycodiazin
N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
Glycodiazin [German]
UNII-4C5I4BQZ8F
EINECS 206-426-5
4C5I4BQZ8F
N-(5-(2-Methoxyethoxy)pyrimidin-2-yl)benzenesulfonamide
BRN 0552655
5-beta-(Methoxyethoxy)-2-(phenylsulfonylamido)pyrimidine
N-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulfonamide
GLYMIDINE [MI]
Benzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-
2-Benzolsulfonamido-5-beta-methoxy-aethoxy-pyrimidine [German]
GLYMIDINE [WHO-DD]
2-Benzolsulfonamido-5-beta-methoxy-aethoxy-pyrimidine
DTXSID1023108
CHEBI:146188
5-25-12-00549 (Beilstein Handbook Reference)
2-benzenesulfonamido-5-(2-methoxyethoxy)pyrimidine
2-Benzolsulfonamido-5-.beta.-methoxy-aethoxy-pyrimidine
N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide
N-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulphonamide
5-.beta.-(Methoxyethoxy)-2-(phenylsulfonylamido)pyrimidine
Benzenesulfonamide, N-[5-(2-methoxyethoxy)-2-pyrimidinyl]-
(N-(5-(2-METHOXYETHOXY)-2-PYRIMIDINYL)BENZENESULFONAMIDO)
N-[5-(2-methoxyethoxy)-2-pyrimidinyl]benzenesulphonamide
Benzenesulfonamide, N-[5-(2-methoxyethoxy)-2-pyrimidinyl]-; 2-Benzenesulfonamido-5-(2-methoxyethoxy)pyrimidine; Glidiazine; Glymidine; N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide
SCHEMBL34389
DTXCID703108
CHEMBL1697838
EX-A5946
N-(5-{[2-(methyloxy)ethyl]oxy}pyrimidin-2-yl)benzenesulfonamide
AKOS027327087
DB01382
SB58445
DA-55898
HY-116844
CS-0066673
NS00009911
EN300-22686192
Q5572813
2-Benzolsulfonylamino-5(beta-methoxy-athoxy)-pyrimidin
206-426-5