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N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide

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Identification
Molecular formula
C9H8N4OS
CAS number
771-55-9
IUPAC name
N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide
State
State

The compound is in a solid state at room temperature, characterized by its crystalline form. It is not volatile under normal conditions.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
417.20
Boiling point (Kelvin)
690.35
General information
Molecular weight
219.25g/mol
Molar mass
219.2510g/mol
Density
1.3550g/cm3
Appearence

N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide is typically found as a white to pale yellow crystalline solid. Its crystalline nature is indicative of its purity and is often used as a key characteristic for identification.

Comment on solubility

Solubility of N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide

N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide exhibits interesting solubility characteristics that can influence its applications and effectiveness in various environments.

Generally, the solubility of this compound can be influenced by several factors:

  • Polarity: Due to the presence of a pyridine ring and functional groups, the compound tends to have moderate to high polarity, potentially enhancing its solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The acetamide group can engage in hydrogen bonding, making it soluble in solvents capable of hydrogen bonding.
  • Electrostatic Interactions: The nitrogen atoms in the thiadiazole and pyridine rings contribute to partial charges, which may facilitate solubility in ionic or polar solvent systems.

Experimental solubility assessments indicate that:

  • The compound is soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), confirming its compatibility with other polar organic solvents.
  • Its solubility in water is limited, which may restrict its use in aqueous formulations.

As stated in solubility theory, "Like dissolves like". Hence, the characteristics of N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide suggest a preference for polar and protic solvents, thereby emphasizing the importance of solvent selection in experimental setups or applications involving this compound.

Interesting facts

Interesting Facts about N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide

N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide is a fascinating compound that showcases the intricate world of heterocyclic chemistry. This compound is not just a simple molecule; it is a complex structure that offers a myriad of applications in various fields, particularly in medicinal chemistry and agricultural science.

Key Highlights:

  • Heterocyclic Nature: The presence of both a thiadiazole ring and a pyridine moiety contributes to the compound's unique chemical properties, enhancing its potential for diverse applications.
  • Biological Activity: Compounds containing thiadiazole and pyridine structures have been shown to exhibit antimicrobial, antitumor, and anti-inflammatory properties, making them significant in pharmaceutical research.
  • Synthetic Potential: The synthesis of N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide can be approached through various methods, allowing chemists to manipulate its properties for specific applications.
  • Research Interest: Ongoing studies focus on exploring the compound's mechanism of action and optimization for various biological activities, providing insights into future drug development.

Moreover, the versatility of N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide as a scaffold for the development of novel compounds cannot be overstated. As researchers continue to explore its potential, this compound stands as a testament to the innovation found in the realm of synthetic chemistry.

In summary, N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide exemplifies the exciting interplay between structure and function in chemistry, inviting scientists to dive deeper into its possibilities.

Synonyms
3652-14-0
2-Acetamido-5-(4-pyridyl)-1,3,4-thiadiazole
BRN 0198030
ACETAMIDE, N-(5-(4-PYRIDYL)-1,3,4-THIADIAZOL-2-YL)-
1,3,4-Thiadiazole, 2-acetamido-5-(4-pyridyl)-
DTXSID20190018
4-27-00-09444 (Beilstein Handbook Reference)
DTXCID30112509
N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)acetamide
2-Acetylamino-5-(4-pyridyl)-1,3,4-thiadiazole
Cambridge id 6159421
Oprea1_238543
Oprea1_646474
N-[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]acetamide
STK374701
AKOS000656256
SDCCGMLS-0065530.P001
AB00103086-01
5-acetylamino-2-(4-pyridyl)-1,3,4-thiadiazole
AP-263/09121017
SR-01000449644
SR-01000449644-1
N-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]acetamide
Z199471388
N~1~-[5-(4-PYRIDYL)-1,3,4-THIADIAZOL-2-YL]ACETAMIDE