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Furazolidone

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Identification
Molecular formula
C8H7N3O5S
CAS number
67-45-8
IUPAC name
N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide
State
State

Furazolidone is in a solid state at room temperature. It is often supplied as a powder, which can be then processed or compounded as needed for its application in microbiological studies or medicinal formulations.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
343.00
Boiling point (Kelvin)
616.15
General information
Molecular weight
225.16g/mol
Molar mass
225.1560g/mol
Density
1.6770g/cm3
Appearence

Furazolidone typically appears as a yellow, crystalline powder. Its vibrant coloration is characteristic of many nitrofurans, which are known for their intense hues.

Comment on solubility

Solubility of N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide

N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide is a compound of notable interest due to its unique structure and potential applications. When discussing its solubility, several factors come into play:

  • Polarity: The presence of the nitro group and the thiadiazole ring contributes to the overall polarity of the molecule, which can influence its solubility in various solvents.
  • Solvent Type: Typically, this compound may exhibit better solubility in polar solvents such as water or alcohols when compared to non-polar solvents.
  • Temperature Effects: Solubility can often increase with temperature, which is a crucial consideration during dissolution processes.
  • Concentration Limits: At higher concentrations, solubility might decrease due to potential intermolecular interactions that promote aggregation.

As previously noted, "the solubility of a compound can greatly dictate its usability in various chemical formulations." Therefore, for practical applications, it is essential to evaluate the conditions under which N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide can be effectively utilized, ensuring the right solvent choices and conditions are maintained for optimal solubility.

Interesting facts

N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide

N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide is a fascinating chemical compound that has garnered attention in various fields, especially in the realm of pharmaceuticals and agricultural science. Here are some interesting facts about this unique compound:

  • Structure and Functionality: The compound contains a thiadiazole moiety, which is known for its diverse biological properties, including antifungal and antibacterial activities. This unique structure offers potential for innovative drug design.
  • Biological Applications: Compounds with nitrofuran derivatives, like the one in this compound, are often explored for their potential in treating infectious diseases, demonstrating the importance of exploring nitro-functional groups in medicinal chemistry.
  • Research Interest: Scientists are actively studying the compound's efficacy in targeting specific biological pathways, particularly those involved in microbial resistance. As antibiotic resistance becomes a global concern, this compound could play a critical role in future therapeutic strategies.
  • Tailored Synthesis: The synthesis of this compound involves several sophisticated techniques, showcasing the intricacies of modern organic chemistry. Techniques such as cyclization reactions provide an exciting laboratory challenge for chemists.
  • Environmental Impact: The use of thiadiazoles in agrochemicals has opened up discussions around their environmental impact. Evaluating the degradation products of such compounds is crucial for assessing their safety and sustainability.

In conclusion, N-[5-(5-nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide represents a significant intersection of organic chemistry and potential medicinal application, highlighting the importance of exploring various chemical landscapes for breakthroughs in health and agriculture. As stated in the field, "Chemistry is the study of change," and compounds like these epitomize that transformative power.

Synonyms
C 132
Furothiazole (the bactericide)
CCRIS 1194
WTX9WQ5N4D
C 132 (VAN)
NSC 523298
BRN 1084382
N-(5-(5-Nitro-2-furyl)-1,3,4-thiadiazol-2-yl)acetamide
UNII-WTX9WQ5N4D
NSC-523298
N-[5-(5-Nitro-2-furyl)-1,3,4-thiadiazol-2-yl]acetamide
DTXSID9020950
ACETAMIDE, N-(5-(5-NITRO-2-FURYL)-1,3,4-THIADIAZOL-2-YL)-
NITRO-2-FURANYL)-1,3,4-THIADIAZOL-2-YL)ACETAMIDE, N-(5-(5-
DTXCID90950
2578-75-8
N-(5-(5-Nitro-2-furanyl)-1,3,4-thiadiazol-2-yl)acetamide
N-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]acetamide
1,3,4-Thiadiazole, 2-acetamido-5-(5-nitro-2-furyl)-
Acetamide, N-(5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl)-
1,3,4-Thiadiazole, 2-acetamido-5- (5-nitro-2-furyl)-
Oprea1_808342
CHEMBL260123
NSC523298
AKOS040751881
DS-002326
WLN: T5OJ BNW E- ET5NN DSJ CMV1
1,4-Thiadiazole, 2-acetamido-5-(5-nitro-2-furyl)-
N-[5-(5-Nitro-2-furyl)-1,4-thiadiazol-2-yl]acetamide
Acetamide,n-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
N-[5-(5-nitro-2-furyl)-1,3,4-thi-adiazol-2-yl]acetamide