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N-(5-chloro-2-fluoro-phenyl)acetamide

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Identification
Molecular formula
C8H7ClFNO
CAS number
261951-88-4
IUPAC name
N-(5-chloro-2-fluoro-phenyl)acetamide
State
State

At room temperature, N-(5-chloro-2-fluoro-phenyl)acetamide is a solid. It is not volatile, and it maintains its solid-state under standard conditions, making it relatively stable for handling in laboratories.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
295.80
Boiling point (Kelvin)
568.95
General information
Molecular weight
187.60g/mol
Molar mass
187.5980g/mol
Density
1.3220g/cm3
Appearence

N-(5-chloro-2-fluoro-phenyl)acetamide typically appears as a white to off-white crystalline powder. It is a solid at room temperature and has no significant odor.

Comment on solubility

Solubility of N-(5-chloro-2-fluoro-phenyl)acetamide

N-(5-chloro-2-fluoro-phenyl)acetamide is a compound that exhibits interesting solubility characteristics. The solubility of this compound can be influenced by several factors, including temperature, pH, and solvent type. Generally, compounds of this nature can be categorized based on their solubility in polar and non-polar solvents.

Key Points Regarding Solubility:

  • Polar Solvents: N-(5-chloro-2-fluoro-phenyl)acetamide tends to have moderate solubility in water due to its polar functional groups, which can engage in hydrogen bonding.
  • Non-Polar Solvents: It demonstrates better solubility in organic solvents such as ethanol and acetone, which are less polar and can stabilize the aromatic structure of the compound.
  • Temperature Dependency: As the temperature increases, the solubility of organic compounds often increases, indicating that heating the solution may improve the dissolution of N-(5-chloro-2-fluoro-phenyl)acetamide.
  • pH Influence: The ionization of the amide group can be affected by the pH of the solution, which may further alter its solubility characteristics.

Because of these factors, it is crucial to consider solvent choice and conditions when assessing the solubility of N-(5-chloro-2-fluoro-phenyl)acetamide. Understanding these interactions paves the way for optimizing its use in various applications.

Interesting facts

Interesting Facts about N-(5-chloro-2-fluoro-phenyl)acetamide

N-(5-chloro-2-fluoro-phenyl)acetamide is a fascinating compound with several intriguing attributes worth exploring.

Chemical Structure and Properties

  • The compound presents a unique combination of a chloro and a fluoro substituent on the phenyl ring, which often influences the compound's reactivity and interactions with biological systems.
  • Such halogenated compounds can enhance lipophilicity, potentially improving the ability of the molecule to permeate cellular membranes.

Applications in Science and Medicine

  • This compound belongs to a class of chemicals that can exhibit significant pharmaceutical activity, making it a candidate for medicinal chemistry research.
  • Compounds like this can be evaluated for their potential as antimicrobial agents or as precursors for drug development due to their interaction with biological targets.

Research Insights

Studies have suggested that derivatives of acetamides have diverse biological profiles which can lead to:

  • Effective treatments for various conditions
  • Research into its mechanism of action can contribute to the broader understanding of drug design and efficacy

As noted by chemists, "The strategic introduction of halogen atoms can significantly impact the pharmacological properties of a compound." This concept is essential in developing new medications aimed at specific therapeutic targets.

In summary, N-(5-chloro-2-fluoro-phenyl)acetamide serves as an excellent example of how structural modifications can lead to varied biological activities, making it a subject of ongoing scientific inquiry.

Synonyms
N-(5-chloro-2-fluorophenyl)acetamide
398-89-0
5'-Chloro-2'-fluoroacetanilide
ACETANILIDE, 5'-CHLORO-2'-FLUORO-
R3MBH8V6UB
NSC 10346
BRN 3257555
Acetamide, N-(5-chloro-2-fluorophenyl)-
NSC-10346
DTXSID60192874
4-12-00-01239 (Beilstein Handbook Reference)
WLN: GR DF CMV1
NSC10346
UNII-R3MBH8V6UB
SCHEMBL9403860
DTXCID00115365
AKOS008917319