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5-Hydroxy-2-acetamidofluorene

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Identification
Molecular formula
C15H13NO2
CAS number
2208-34-6
IUPAC name
N-(5-hydroxy-9H-fluoren-2-yl)acetamide
State
State

At room temperature, 5-Hydroxy-2-acetamidofluorene is in a solid state. It is generally stable under standard atmospheric conditions, provided it is stored away from excessive moisture and light.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.15
General information
Molecular weight
239.27g/mol
Molar mass
239.2700g/mol
Density
1.3650g/cm3
Appearence

5-Hydroxy-2-acetamidofluorene appears as a white to off-white crystalline solid. The compound typically forms needle-like crystals and can display slight yellowish hues. It is important to store it under light-protective conditions to prevent any discoloration or degradation due to light exposure.

Comment on solubility

Solubility of N-(5-hydroxy-9H-fluoren-2-yl)acetamide

N-(5-hydroxy-9H-fluoren-2-yl)acetamide exhibits intriguing solubility characteristics that play a crucial role in its potential applications in various fields. Here are some key points regarding its solubility:

  • Polar Solvents: This compound tends to dissolve well in polar solvents due to the presence of hydroxyl (-OH) and amide (-NH2) functional groups. These groups can form hydrogen bonds, enhancing solubility.
  • Non-Polar Solvents: While it may have limited solubility in non-polar solvents, its aromatic structure suggests that some interaction may still occur, albeit weakly.
  • Water Solubility: The solubility in water is moderate, driven by the compound's ability to form hydrogen bonds with water molecules.
  • Temperature Influence: Increased temperature can enhance solubility, making it more versatile in different conditions.

In summary, the solubility of N-(5-hydroxy-9H-fluoren-2-yl)acetamide is largely influenced by its functional groups and the nature of the solvent. As one quote aptly puts it, "The choice of solvent can sometimes make all the difference in the world of chemistry."

Interesting facts

Interesting Facts About N-(5-hydroxy-9H-fluoren-2-yl)acetamide

N-(5-hydroxy-9H-fluoren-2-yl)acetamide, a fascinating compound in the realm of organic chemistry, showcases the intricate relationship between structure and function in molecular design. Here are some captivating insights:

  • Structural Significance: This compound features a unique fluorenyl group, which plays a critical role in various biological activities, including potential anti-cancer properties. The presence of the hydroxyl group further enhances its reactivity and solubility in biological systems.
  • Potential Applications: Researchers are investigating its use in pharmaceuticals, particularly in the development of new therapeutic agents due to its structural similarity to established medicinal compounds.
  • Biological Relevance: The incorporation of the acetamide functional group is known to improve the pharmacological properties of molecules, potentially leading to increased efficacy and reduced side effects in drug formulation.
  • Synthetic Routes: The synthesis of N-(5-hydroxy-9H-fluoren-2-yl)acetamide can involve various methods, including the acylation of 5-hydroxyfluoren-2-amine, showcasing the versatility of synthetic organic chemistry techniques.
  • Research Interest: Its unique structure has garnered attention in academic and industrial research, leading to studies on its behavior in bioassays and its interaction with biological macromolecules.

In summary, N-(5-hydroxy-9H-fluoren-2-yl)acetamide exemplifies the intricacies of organic compound design and its potential brilliance in medicinal chemistry. As scientists continue to explore its properties and applications, this compound may hold the key to future breakthroughs in therapeutic techniques.

Synonyms
1147-55-3
N-(5-hydroxy-9H-fluoren-2-yl)acetamide
5-Hydroxy-2-acetylaminofluorene
ACETAMIDE, N-(5-HYDROXY-9H-FLUOREN-2-YL)-
5-Hydroxy-2-acetamidofluorene
5-Hydroxy-2-(acetylamino)fluorene
N-(5-Hydroxy-9H-fluoren-2-yl)-acetamide
CHEBI:34455
5-Hydroxyacetylaminofluorene
CCRIS 1063
5-Hydroxy-N-2-fluorenylacetamide
NSC 9867
BRN 2811030
Acetamide,N-(5-hydroxy-9H-fluoren-2-yl)-
CHEMBL1908022
DTXSID80150835
NSC9867
NSC-9867
N-(5-Hydroxy-2-fluorenyl)acetamide
DS-006288
NS00115903
Q27116081