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Nitrofurazone Dihydrochloride

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Identification
Molecular formula
C12H13Cl2N5O4
CAS number
59-87-0
IUPAC name
N-[(5-nitro-2-furyl)methyleneamino]-2-piperazin-1-yl-acetamide;dihydrochloride
State
State

At room temperature, nitrofurazone dihydrochloride is usually encountered as a solid. It is commonly used in this state in various applications.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.00
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
271.26g/mol
Molar mass
271.2640g/mol
Density
1.5400g/cm3
Appearence

Nitrofurazone dihydrochloride appears as a crystalline solid that is typically yellow or yellowish-brown in color. It is often soluble in water and can be used in various pharmaceutical formulations.

Comment on solubility

Solubility of N-[(5-nitro-2-furyl)methyleneamino]-2-piperazin-1-yl-acetamide; dihydrochloride

The solubility of N-[(5-nitro-2-furyl)methyleneamino]-2-piperazin-1-yl-acetamide; dihydrochloride can be influenced by various factors, primarily due to its hydrochloride salt form. Generally, salts tend to have enhanced solubility in polar solvents, particularly water, due to their ability to ionize.

  • Polar Solvents: The compound is expected to dissolve well in water because of the presence of ionic interactions from the dihydrochloride moiety.
  • Solvent Dependency: While it may exhibit good solubility in water, the solubility in organic solvents (like ethanol or methanol) can vary significantly. A thorough examination is required to determine its behavior in such solvents.
  • Temperature Influence: Increasing the temperature may enhance solubility for many compounds. Hence, investigations at various temperatures could yield useful data.

To sum up, the solubility of N-[(5-nitro-2-furyl)methyleneamino]-2-piperazin-1-yl-acetamide; dihydrochloride can be described as effectively soluble in aqueous solutions, owing to its ionic nature, but its performance in non-polar or less polar solvents warrants deeper analysis to fully understand its solvation dynamics.

Interesting facts

Overview of N-[(5-Nitro-2-furyl)methyleneamino]-2-piperazin-1-yl-acetamide Dihydrochloride

This compound, known for its complex structure, exhibits a fascinating blend of functional groups that contribute to its unique properties and potential applications. As a derivative of piperazine, a well-known building block in medicinal chemistry, it opens doors to various research ventures.

Interesting Characteristics

  • Biological Activity: The structure features a nitro group attached to a furan ring, which is crucial for its biological activity. Compounds like this are often studied for their pharmacological properties, including antimicrobial and anticancer activity.
  • Structural Versatility: The presence of both piperazine and furan moieties allows for extensive modifications, leading to a library of derivatives that can be tailored for specific activities allowing scientists to explore new therapeutic avenues.
  • Stability Considerations: The dihydrochloride form suggests improved solubility in water compared to its free base, thus enhancing its accessibility for biological testing.
  • Potential Applications: Due to its structural characteristics, this compound may be investigated in fields such as medicinal chemistry, agrochemicals, or materials science.

Research Opportunities

This compound serves as an excellent candidate for further exploration. Potential research focuses include:

  • Investigating the mechanism by which it exerts its biological effects
  • Conducting structure-activity relationship (SAR) studies to enhance its efficacy
  • Examining its interactions with biological molecules

As scientists continue to unravel the complexities of this compound, it stands to contribute significantly to our understanding of synthetic and organic chemistry. The unique combination of piperazine and nitrofuran elements presents a rich ground for innovation in drug discovery.