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N-(5-nitrothiazol-2-yl)acetamide

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Identification
Molecular formula
C5H5N3O3S
CAS number
5408-65-1
IUPAC name
N-(5-nitrothiazol-2-yl)acetamide
State
State

The compound is generally found in solid state at room temperature. Its crystalline form ensures a stable structure under normal storage conditions.

Melting point (Celsius)
188.00
Melting point (Kelvin)
461.15
Boiling point (Celsius)
329.40
Boiling point (Kelvin)
602.55
General information
Molecular weight
201.20g/mol
Molar mass
201.1950g/mol
Density
1.5890g/cm3
Appearence

N-(5-nitrothiazol-2-yl)acetamide typically appears as a solid crystalline substance. The specific coloration and granularity can depend on the purity and the form of the sample.

Comment on solubility

Solubility of N-(5-nitrothiazol-2-yl)acetamide

N-(5-nitrothiazol-2-yl)acetamide is an intriguing compound due to its unique structural characteristics, which influence its solubility parameters. Solubility can be affected by several factors including:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while hydrophobic regions may favor non-polar solvents.
  • Temperature: Increasing temperature often increases solubility, particularly for solid compounds.
  • pH Levels: The ionization state of the compound can change with pH, affecting its solubility in aqueous solutions.
  • Interactions with Solvents: Hydrogen bonding, van der Waals forces, and dipole-dipole interactions play significant roles.

To quote a common understanding in chemistry, "Like dissolves like." This principle suggests that N-(5-nitrothiazol-2-yl)acetamide will have better solubility in solvents that share similar polarity and functional characteristics. Test results indicate that:

  • It displays reasonable solubility in polar organic solvents due to the nitro and amide groups.
  • Solubility in water is limited, which is typical for many moderately polar compounds.

In conclusion, the solubility of N-(5-nitrothiazol-2-yl)acetamide reflects a balance of structural characteristics and external conditions, leading to its application in various chemical contexts.

Interesting facts

Interesting Facts about N-(5-Nitrothiazol-2-yl)acetamide

N-(5-nitrothiazol-2-yl)acetamide is a compound of notable interest within the field of medicinal chemistry due to its intriguing structure and potential applications. Here are some compelling points to consider:

  • Bioactivity: This compound is recognized for its potential as an antimicrobial agent, showing efficacy against a variety of pathogens. The nitrothiazole moiety is particularly significant in enhancing its bioactivity.
  • Mechanism of Action: The presence of the nitro group enables the compound to participate in redox reactions, potentially leading to the generation of reactive species that can disrupt cellular processes in target organisms.
  • Synthetic Versatility: N-(5-nitrothiazol-2-yl)acetamide can be synthesized through diverse approaches, making it an excellent candidate for exploring structure-activity relationships in drug development.
  • Research Implications: Its unique thiazole ring structure opens avenues for further investigation in the development of new pharmaceuticals. Researchers often explore derivatives of this compound to optimize its efficacy and selectivity.
  • Inhibition Studies: Studies involving this compound often focus on its ability to inhibit specific enzymes, contributing valuable information to the field of enzymology and drug discovery.

In conclusion, N-(5-nitrothiazol-2-yl)acetamide embodies a fascinating intersection of chemistry and biology. Its potential applications and unique characteristics make it a compound worthy of further exploration and study in various scientific disciplines.

Synonyms
Nithiamide
2-Acetamido-5-nitrothiazole
140-40-9
Aminitrozole
Acinitrazole
Gynofon
Nitazole
Tritheon
Ametoterina
Aminitrozol
Lavoflagin
Pleocide
Trichlorad
Trichocid
Trichoman
Trichoral
Tricogen
Tricoral
Trikolaval
Nitasol
Nitazol
Acetyl enheptin
Cyzine premix
Aminitrazol
Trichorad
Tricolaval
Tricosteril
Acetamide, N-(5-nitro-2-thiazolyl)-
Enheptin A
N-(5-Nitrothiazol-2-yl)acetamide
Acinitrazol
Tricosil
Torion
Nithiamide [USAN]
N-(5-Nitro-2-thiazolyl)acetamide
5-Nitro-2-acetamidothiazole
CL 5279
N-(5-Nitro-1,3-thiazol-2-yl)acetamide
Aminitrozolum
Amminitrozol
2-Acetamino-5-nitrothiazole
CL 5,279
Aminitrozolum [INN-Latin]
Aminitrozole [INN]
5-Nitro-2-acetilaminotiazolo
NSC 31539
Aminitrazole
Amminitrozol [INN-Spanish, French]
EINECS 205-414-7
NSC 45914
NSC-31539
NSC-45914
UNII-9CBM60191Z
Nithiamide (USAN)
RP 8243
5-Nitro-2-acetilaminotiazolo [Italian]
Aminitrozole (INN)
BRN 0167361
THIAZOLE, 2-ACETAMIDO-5-NITRO-
DTXSID6046391
2-(Acetylamino)-5-nitrothiazole
9CBM60191Z
CL-5279;Aminitrozole
AMINITROZOLE [MI]
MFCD00022438
CL-5279
2-Acetamide-5-nitrothiazole
AMINITROZOLE [MART.]
AMINITROZOLE [WHO-DD]
Enheptin-A
DTXCID4026391
4-27-00-04676 (Beilstein Handbook Reference)
NSC31539
NSC45914
NCGC00164494-01
NCGC00164494-02
Aminitrozolum (INN-Latin)
AMINITROZOLE (MART.)
Amminitrozol (INN-Spanish, French)
CAS-140-40-9
Nitrazol
2-acetylamino-5-nitrothiazole
Maybridge1_004150
Oprea1_442078
MLS004734635
SCHEMBL158858
CHEMBL1872946
SCHEMBL22345094
HMS553E16
CHEBI:134832
HMS3264P19
HMS3652L17
Pharmakon1600-01505448
HY-B0992
Tox21_112132
NSC759136
s4232
STK386433
AKOS002232638
Tox21_112132_1
CCG-213449
CS-4486
NSC-759136
NCGC00164494-03
AS-56158
SMR001549986
SY038271
N-(5-nitro-1,3-thiazol-2-yl)ethanamide
DB-000132
A0689
N-(5-Nitro-1,3-thiazol-2-yl)acetamide #
NS00024548
SW219579-1
C72605
D05176
AB01563317_01
AB01563317_02
EN300-7400817
A807648
SR-07000004482
SR-07000004482-3
BRD-K39467894-001-01-8
BRD-K39467894-001-04-2
BRD-K39467894-001-05-9
BRD-K39467894-001-06-7
NITHIAMIDE, Nithiamide (2-Acetamido-5-nitrothiazole)
Q27272354
Z223198462
2-Acetamido-5-nitrothiazole, VETRANAL(TM), analytical standard