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Piribedil

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Identification
Molecular formula
C16H18N2O2
CAS number
3605-01-4
IUPAC name
N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide
State
State

At room temperature, piribedil is a solid compound available as a powder which is usually formulated into tablets for pharmaceutical use.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
634.50
Boiling point (Kelvin)
907.65
General information
Molecular weight
280.34g/mol
Molar mass
280.3570g/mol
Density
1.3500g/cm3
Appearence

Piribedil appears as a crystalline, white to off-white powder. It is typically used in its hydrochloride form which also shares similar physical characteristics.

Comment on solubility

Solubility Characteristics of N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide

The solubility of N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide is influenced by several factors due to its unique chemical structure. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydrophilic (i.e., amide and amine functional groups) and hydrophobic (i.e., cycloheptatriene system) portions suggests that this compound may have variable solubility in different solvents.
  • Solvent Compatibility: It is expected to show higher solubility in polar solvents such as water and dimethyl sulfoxide (DMSO), while its solubility in non-polar solvents may be significantly lower.
  • Temperature Dependence: Solubility may also be temperature-dependent, with an increase in temperature potentially enhancing solubility in certain solvents.
  • pH Influence: Changes in the solution's pH could affect the ionization of the amine group, thereby impacting solubility characteristics.

In conclusion, while specific solubility data for N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide is not abundantly detailed in current literature, understanding its chemical structure suggests a nuanced behavior in different solvent environments. It embodies an intriguing balance between polar and nonpolar characteristics that dictates its interaction with various solvents.

Interesting facts

Interesting Facts about N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide

N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide is a fascinating compound in the realm of medicinal chemistry, particularly due to its structural complexity and potential therapeutic applications. Here are some engaging facts that highlight its significance:

  • Biological Activity: This compound exhibits a variety of biological activities, making it a subject of interest for researchers exploring new drug development. It's crucial in the field of pharmacology for understanding how similar structures can influence biological pathways.
  • Structure-Activity Relationship (SAR): The unique cycloheptatriene ring system in this compound allows scientists to investigate how structural modifications can affect its activity, enhancing our understanding of the SAR which is essential in drug design.
  • Piperidine Derivatives: The presence of the piperidine moiety is significant, as this functional group is commonly found in many pharmaceutical agents. Its properties lend to varying degrees of potency and selectivity, promising intriguing possibilities for development.
  • Development Potential: Compounds with complex structures often serve as essential lead compounds in drug discovery, potentially leading to innovative treatments for diseases, especially in neuropharmacology as it may interact with central nervous system targets.
  • Research and Synthesis: The synthesis of this compound can be a challenging but rewarding process. It often requires advanced techniques in organic chemistry, providing students and researchers with a hands-on opportunity to hone their skills in synthetic methods and purification techniques.

In summary, N-[5-oxo-4-[2-(1-piperidyl)ethylamino]cyclohepta-1,3,6-trien-1-yl]acetamide stands out due to its intriguing structure and potential as a pharmaceutical agent. As scientists continue to delve deeper into its properties, it could unveil new pathways for drug discovery and therapeutic advancements.

Synonyms
BRN 1322752
ACETAMIDE, N-(5-OXO-4-((2-PIPERIDINOETHYL)AMINO)-1,3,6-CYCLOHEPTATRIEN-1-YL)-
15499-14-6
2-(beta-Piperidinoethylamino-5-acetamido)tropone
DTXSID90165773
N-(5-Oxo-4-((2-piperidinoethyl)amino)-1,3,6-cycloheptatrien-1-yl)acetamide
DTXCID4088264