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N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride

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Identification
Molecular formula
C10H8ClN3O2
CAS number
5162-16-7
IUPAC name
N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride
State
State

N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride is generally in a crystalline solid state at room temperature.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
236.65g/mol
Molar mass
236.6500g/mol
Density
1.2860g/cm3
Appearence

The appearance of N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride is typically a solid at room temperature. It may present as a pale yellow to off-white crystalline powder.

Comment on solubility

Solubility of N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride

N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride is a compound that exhibits specific solubility characteristics. Understanding the solubility of this compound is crucial for its application in various chemical processes. Here are some key points regarding its solubility:

  • Polar Solvents: The presence of the carbamoyl chloride group typically indicates that the compound is more soluble in polar solvents such as water and alcohols. This is due to the ability of polar solvents to stabilize charged species and facilitate interaction with the polar functional groups.
  • Solvent Polarity: The solubility may vary significantly based on the solvent's polarity. For instance, it may have reduced solubility in non-polar solvents like hexane.
  • Temperature Influence: As with many compounds, an increase in temperature can enhance solubility in solvents, allowing more of the compound to dissolve.
  • Concentration Effects: As the concentration of the compound increases in a solvent, it may reach a point of saturation where no additional solute can dissolve.

In conclusion, while N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride shows favorable solubility in polar environments, its effectiveness and utility can be significantly influenced by the choice of solvent, temperature, and concentration. As with many chemical compounds, optimal solubility is essential for achieving desired reactivity and performance in various applications.

Interesting facts

Interesting Facts about N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride

N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride is a fascinating compound due to its potential applications and unique structural characteristics. Here are some intriguing aspects of this compound:

  • Pharmaceutical Potential: The compound's oxadiazole moiety is known for its pharmacological activities, making it an exciting subject for drug discovery and design.
  • Reactivity: As a carbamoyl chloride, it serves as an important intermediate in organic synthesis, particularly in the formation of amides and other derivatives.
  • Versatility: The presence of both the phenyl and oxadiazole rings greatly enhances the compound's versatility, allowing for various modifications that can lead to a wide array of derivatives with specialized functions.
  • Research Interest: Researchers are continuously investigating this compound for its potential biological applications, including anti-cancer and anti-inflammatory activities.
  • Synthetic Routes: The compound can be synthesized through various methods, including condensation reactions and leveraging the reactivity of isocyanates, showcasing the creativity required in synthetic organic chemistry.

In summary, N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride is not just a chemical structure but a promising scaffold for the development of innovative therapeutic agents and a valuable entity in the world of organic synthesis. As stated by one prominent chemist, "The beauty of synthetic chemistry lies in transforming simple building blocks into complex molecules with profound implications."


Synonyms
2-(Chloroacetamido)-5-phenyl-1,3,4-oxadiazole
BRN 0531655
1,3,4-OXADIAZOLE, 2-(CHLOROACETAMIDO)-5-PHENYL-
7659-20-3
N-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]carbamoyl chloride
[(5-phenyl-1,3,4-oxadiazol-2-yl)methylamino]formyl chloride
DTXSID20997923
[(5-Phenyl-1,3,4-oxadiazol-2-yl)methyl]carbonochloridimidic acid