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N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Identification
Molecular formula
C12H15N3O2S2
CAS number
745778-96-9
IUPAC name
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
State
State

At room temperature, N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is in a solid state, often present as a crystalline powder.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.20
Boiling point (Celsius)
390.70
Boiling point (Kelvin)
663.90
General information
Molecular weight
295.42g/mol
Molar mass
295.4150g/mol
Density
1.3150g/cm3
Appearence

N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide typically appears as a white to off-white crystalline powder. The appearance may vary slightly due to purity and other factors.

Comment on solubility

Solubility of N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

The solubility of N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide (C12H15N3O2S2) can be quite intriguing, as it showcases the unique interactions due to its structural components. Understanding the solubility of this compound involves considering several factors:

  • Polarity: The presence of sulfonamide and thiadiazole groups contributes to the overall polarity of the compound.
  • Solvent Compatibility: Solubility can vary significantly depending on the solvent used. For instance, it is more likely to dissolve in polar solvents such as water and dimethyl sulfoxide (DMSO).
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can enhance solubility in polar solvents.
  • Temperature Influence: Increased temperature often facilitates greater solubility for many organic compounds.

Overall, the solubility of N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is impacted by its molecular structure, which balances hydrophobic and hydrophilic characteristics. It is essential to remember that the compound's unique attributes may lead to varied solubility in different environments. As a key takeaway, the solubility can be tuned or influenced through appropriate solvent selection and environmental conditions.

Interesting facts

Interesting Facts about N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide is a fascinating compound that brings together a rich array of functional groups and structural elements. Here are some intriguing highlights about this unique chemical:

  • Thiadiazole Influence: The presence of the 1,3,4-thiadiazole ring is quite significant. This heterocyclic structure is known for its diverse biological activities, including antibacterial, antifungal, and anti-inflammatory properties.
  • Functional Versatility: The sulfonamide moiety includes a sulfonyl group, which enhances the compound’s reactivity and interaction with biological targets, making it a prominent candidate for pharmaceutical research.
  • Structural Diversity: The incorporation of the tert-butyl group not only influences the steric properties of the molecule but also contributes to increased lipophilicity, which may affect its absorption and distribution within biological systems.
  • Pharmaceutical Potential: Compounds featuring similar structural motifs have been investigated for their potential in drug development, particularly as antimicrobial agents. The design of this molecule hints at potential efficacy in treating infections.
  • Synthetic Routes: The synthesis of this compound can serve as a practical exercise in organic chemistry, showcasing reactions such as nucleophilic substitutions and cyclization techniques. Students may find it a rewarding project in the laboratory.

In summary, N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide represents a rich interplay of chemistry and biology, carrying with it both structural elegance and potential applications in medicinal chemistry. As the field of drug discovery continues to expand, compounds like this remain at the forefront of research and innovation.

Synonyms
glybuzole
1492-02-0
Gludiase
Desaglybuzole
N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
Glibuzol
AN 1324
RP 7891
2-Benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole
1DJ2B68M2C
DTXSID6023103
Desaglybuzole; Sulfamidothiodiazol
AN-1324
RP-7891
NCGC00182991-01
sulfamidothiodiazol
Glybuzolum
Glybuzole [INN:JAN]
Glibuzol [INN-Spanish]
Glybuzolum [INN-Latin]
SR-01000945213
EINECS 216-081-2
TH-1395
BRN 1082473
UNII-1DJ2B68M2C
Gludiase (TN)
2-Benzenesulfonamido-5-tertiobutyl-1-thia-3,4-diazole
Glybuzole (JAN/INN)
GLYBUZOLE [INN]
GLYBUZOLE [JAN]
Benzenesulfonamide, N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
GLYBUZOLE [MI]
GLYBUZOLE [MART.]
GLYBUZOLE [WHO-DD]
Oprea1_425860
SCHEMBL34401
DTXCID703103
CHEMBL2107408
CHEBI:31657
NMWQEPCLNXHPDX-UHFFFAOYSA-N
Tox21_113322
N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
AKOS003615177
CAS-1492-02-0
DB-320470
HY-120401
CS-0077885
NS00024883
D01210
EN300-1700032
SR-01000945213-1
SR-01000945213-2
Q27252286
Z57070444