Skip to main content

Quinoline-6-carboxamide

ADVERTISEMENT
Identification
Molecular formula
C11H10N2O
CAS number
61995-34-6
IUPAC name
N-(6-quinolyl)acetamide
State
State

At room temperature, N-(6-quinolyl)acetamide is in a solid state, typically forming white crystals. It is stable under standard room conditions.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.00
Boiling point (Celsius)
431.00
Boiling point (Kelvin)
704.00
General information
Molecular weight
186.21g/mol
Molar mass
186.2110g/mol
Density
1.3060g/cm3
Appearence

N-(6-quinolyl)acetamide is typically observed as a crystalline solid with a white to off-white color. It forms well-defined crystals that are powdery or clumped depending on its state, purity, and conditions of storage.

Comment on solubility

Solubility of N-(6-quinolyl)acetamide

N-(6-quinolyl)acetamide, with a unique structural framework, presents interesting solubility characteristics that are worth noting. Understanding its solubility can aid in various applications and manipulations in chemical processes.

Solubility Insights:

  • Polar vs. Non-polar: N-(6-quinolyl)acetamide is known to display moderate solubility in polar solvents such as water and alcohols. This is attributed to its amide functional group, which can engage in hydrogen bonding.
  • Solvent Compatibility: It dissolves well in:
    • Water
    • Dimethyl sulfoxide (DMSO)
    • Ethyl alcohol
  • Temperature Dependency: The solubility may increase with temperature, which is a common trend observed in many organic compounds.
  • Impurities Effect: The presence of impurities or different pH levels in the solvent can significantly affect the solubility. As the pH shifts, the ionization state of the compound may alter, impacting its solubility.

In summary, the solubility of N-(6-quinolyl)acetamide is shaped by its specific functional groups and interactions with solvents. Its moderate polar nature allows for versatility in dissolving across a range of environments, making it an appealing compound for research and applications.

Interesting facts

Interesting Facts about N-(6-quinolyl)acetamide

N-(6-quinolyl)acetamide is a fascinating compound that boasts a variety of notable features and applications in the field of chemistry.

Chemical Structure

The compound is structured around a quinoline base, specifically 6-quinoline, which is known for its aromatic characteristics. This unique structure provides:

  • Stability: The presence of an aromatic system lends stability to the compound.
  • Electron-rich nature: The nitrogen atom in the quinoline ring contributes to its electron density, making it useful in various chemical reactions.

Applications in Research

N-(6-quinolyl)acetamide has gained attention in different areas of research, including:

  • Medicinal Chemistry: This compound's derivatives are being investigated for potential antitumor and antimicrobial activities, highlighting its promise in drug development.
  • Coordination Chemistry: The nitrogen lone pair can act as a ligand, forming complexes with metals that are vital for understanding catalytic processes.

Quinolines in Nature

Quinolines, including N-(6-quinolyl)acetamide, are often found in various natural products. They can:

  • Serve as alkaloids, which are organic compounds containing basic nitrogen atoms.
  • Possess various biological activities, allowing researchers to explore their potential health benefits.

Research Challenges

Despite its potential, working with N-(6-quinolyl)acetamide can present difficulties:

  • Synthesis Challenges: The synthesis of quinoline-based compounds often requires careful control of reaction conditions.
  • Toxicity Concerns: Some quinoline derivatives can exhibit toxicity, necessitating thorough safety assessments in research contexts.

In conclusion, N-(6-quinolyl)acetamide is not only a compound of scientific interest but also a gateway to exploring a wide range of chemical and biological interactions. As research continues to evolve, this compound might unveil even more secrets that could lead to innovative applications in medicine and materials science.

Synonyms
N-(quinolin-6-yl)acetamide
22433-76-7
N-quinolin-6-ylacetamide
Acetamide, N-6-quinolinyl-
6-Acetamidoquinoline
N-(6-quinolyl)acetamide
6-Acetylaminoquinoline
Quinoline, 6-acetamido-
N-6-Quinolylacetamide
ACETAMIDE, N-6-QUINOLYL-
MFCD00460662
NSC-405793
CCRIS 1684
N-(6-Quinolinyl)acetamide
BRN 0136831
N-Quinolin-6-yl-acetamide
MKD9AEB999
Oprea1_133620
5-22-10-00305 (Beilstein Handbook Reference)
N-(6-Quinolinyl)acetamide #
CHEMBL563953
SCHEMBL1538297
SCHEMBL5558963
SCHEMBL27599138
SCHEMBL29728201
DTXSID40176975
GJEUIVYGSBNNKW-UHFFFAOYSA-N
NSC405793
STK391535
AKOS005432512
DS-7907
NSC 405793
SB67491
SY093214
DB-119909
CS-0153968
ST50863412
F14237
AE-848/08322053
F463213