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Tacrine

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Identification
Molecular formula
C13H14ClN3
CAS number
321-64-2
IUPAC name
N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine
State
State

Tacrine, in its standard form, is a solid at room temperature.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
632.80
Boiling point (Kelvin)
905.95
General information
Molecular weight
198.68g/mol
Molar mass
198.6790g/mol
Density
1.2503g/cm3
Appearence

Tacrine hydrochloride has a crystalline powder form. It appears as a white to off-white crystalline substance.

Comment on solubility

Solubility of N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine

The solubility of N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine can be influenced by various factors, mainly due to its complex structure and the presence of several functional groups. Here are some key points to consider:

  • Polarity: The presence of amine groups can enhance solubility in polar solvents, while the hydrophobic aromatic component may limit solubility in pure water.
  • Solvent Type: This compound is likely to be more soluble in organic solvents, such as ethanol or dimethyl sulfoxide (DMSO), compared to water.
  • Temperature Effects: Increased temperature typically enhances the solubility of organic compounds, potentially making this compound more soluble in warmer conditions.
  • pH Influence: The solubility may vary with pH due to the ionization of the amine groups, which could lead to increased solubility at higher pH levels.

In summary, while N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine might exhibit limited solubility in water, its solubility profile can be complex and variable depending on the solvent used and environmental conditions. Understanding these solubility characteristics is crucial for effective application in chemical processes.

Interesting facts

Interesting Facts about N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine

N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine is a compound that combines both aromatic and aliphatic structures, making it a fascinating subject for research. This compound belongs to a class of compounds that have garnered attention in medicinal chemistry due to their potential therapeutic properties. Here are some intriguing aspects:

  • Pharmacological Interest: Compounds with tetrahydroacridine structures, like this one, are often investigated for their neuroprotective and anti-Alzheimer's properties. The structural similarity to certain neurotransmitters makes it a candidate for studies related to cognitive enhancement.
  • Chlorine Substitution: The presence of chlorine atoms in organic compounds can significantly influence their biological activity. 7-chloro compounds are known to exhibit stronger interactions with biological targets, enhancing efficacy.
  • Amine Functions: The diethylamine groups in the structure provide sites for hydrogen bonding, which can facilitate interactions with various biological receptors, lending this compound its unique pharmacological profile.
  • Synthetic Chemistry: The synthesis of such compounds often involves multi-step organic reactions, showcasing the intricate methods chemists use to construct complex molecules from simpler ones.

In summary, N-(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N',N'-diethyl-propane-1,3-diamine serves as a testament to the myriad possibilities within the field of medicinal chemistry. Its unique structure and potential applications make it a compound worth studying.