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N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide

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Identification
Molecular formula
C15H12FNO2
CAS number
20073-80-7
IUPAC name
N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide
State
State

At room temperature, N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide exists as a solid. It retains its form well unless exposed to moisture which may cause it to clump or degrade.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
255.27g/mol
Molar mass
255.2460g/mol
Density
1.4290g/cm3
Appearence

N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide is typically a white to off-white crystalline powder. It may appear slightly yellowish depending on purity and storage conditions.

Comment on solubility

Solubility of N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide

N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide presents an intriguing profile concerning its solubility characteristics. This compound, featuring both hydrophobic and hydrophilic functional groups, showcases a complex balance in terms of solubility in various solvents.

Here are key points regarding its solubility:

  • Polar Solvents: The presence of the hydroxyl group (–OH) suggests that N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide may exhibit reasonable solubility in polar solvents like water and methanol due to hydrogen bonding capabilities.
  • Non-Polar Solvents: Conversely, the fluorenyl structure contributes to hydrophobic interactions, potentially enhancing solubility in non-polar organic solvents such as dichloromethane or ethyl acetate.
  • pH Dependency: As with many compounds featuring functional groups like hydroxyls and amides, solubility may also be affected by the pH of the solution, possibly altering the ionization state.
  • Temperature Effects: Increased temperatures can lead to improved solubility, particularly in solid formulations, facilitating dissolution through enhanced molecular movement.

In summary, the solubility of N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide is influenced by its structural components and the nature of the solvent. Understanding these factors is crucial for practical applications in drug formulation and chemical synthesis.

Interesting facts

Interesting Facts about N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide

N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide is a fascinating compound with several notable aspects that pique scientific interest. Here are some engaging highlights:

  • Structural Significance: This compound features a unique structure that includes a fluorinated fluorenyl group, which is known for enhancing pharmacological properties by improving biological activity.
  • Applications in Research: It has been studied for potential applications in medicinal chemistry, particularly in the development of new therapeutic agents. The introduction of the hydroxy group can significantly influence the compound's reactivity and interaction with biological systems.
  • Gender of Safety: When working with compounds that contain halogens and reactive functional groups, safety precautions must be taken. Proper lab protocols should always be observed to handle this compound effectively.
  • Fluorine's Influence: The presence of fluorine is quite significant in medicinal chemistry. It can modify the lipophilicity and metabolic stability of drugs, which are crucial for their efficacy and bioavailability.
  • Future Prospects: As research continues to uncover the potential health benefits linked to compounds such as N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide, it paves the way for groundbreaking discoveries in drug design and development.

Overall, the exploration of N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-acetamide represents a captivating intersection of chemistry, pharmacology, and innovation. With ongoing studies, we can anticipate further revelations about its applications and potentials in the field of medicine.

Synonyms
7-Fluoro-n-hydroxy-n-2-acetylaminofluorene
2508-18-1
2-(N-Hydroxyacetamido)-7-fluorofluorene
N-Hydroxy-7-fluoro-2-acetylaminofluorene
7-Fluoro-N-(fluoren-2-yl)acetohydroxamic acid
Acetamide, N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-
7-Fluoro-2-N-(fluorenyl)acetohydroxamic acid
N-(7-Fluoro-2-fluorenyl)acetohydroxamic acid
NSC 46523
Acetamide, N-7-fluorofluoren-2-yl-N-hydroxy-
ACETOHYDROXAMIC ACID, N-(7-FLUOROFLUOREN-2-YL)-
BRN 5564895
7-Fluoro-2-N-(fluorenyl)acethydroxamic acid
DTXSID40179769
DTXCID50102260
Acetamide, N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxy-(9CI)
7-Fluoro-2-faa
D8S2LZL9A3
NSC-46523
N-(7-fluoro-9H-fluoren-2-yl)-N-hydroxyacetamide
NSC46523
UNII-D8S2LZL9A3
CHEMBL35220
WLN: L B656 HHJ ENQV1 KF
DS-006293
Acetamide,n-(7-fluoro-9h-fluoren-2-yl)-n-hydroxy-