Skip to main content

7-Fluoro-2-acetamidofluorene

ADVERTISEMENT
Identification
Molecular formula
C15H12FNO
CAS number
17373-82-5
IUPAC name
N-(7-fluoro-9H-fluoren-2-yl)acetamide
State
State

At room temperature, 7-Fluoro-2-acetamidofluorene is in a solid state. It is known to form stable crystals that are pale yellow in color, and the solid-state is consistent due to its molecular structure, which promotes rigidity and crystalline behavior.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
335.30
Boiling point (Kelvin)
608.45
General information
Molecular weight
241.27g/mol
Molar mass
241.2540g/mol
Density
1.3520g/cm3
Appearence

7-Fluoro-2-acetamidofluorene appears as a pale yellow crystalline solid. The compound's structure allows it to form orderly crystals, contributing to its solid-state at room temperature. It tends to be less prone to sublimation due to the acetamide functionality, which increases intermolecular attractions.

Comment on solubility

Solubility of N-(7-fluoro-9H-fluoren-2-yl)acetamide

N-(7-fluoro-9H-fluoren-2-yl)acetamide, with its specific structure, exhibits unique solubility characteristics influenced by its molecular configuration and functional groups.

Generally, the solubility of this compound can be described as follows:

  • Polar Solvents: N-(7-fluoro-9H-fluoren-2-yl)acetamide is likely to show moderate solubility in polar solvents such as water and ethanol due to its acetamide functional group.
  • Non-Polar Solvents: Conversely, it may demonstrate higher solubility in non-polar solvents such as hexane or benzene, attributed to the aromatic fluorene backbone.
  • Temperature Effects: The solubility can also be temperature-dependent, typically increasing with higher temperatures, facilitating better dissolution.

As with many compounds, the interaction with solvents can be complex. Factors to consider include:

  • Hydrogen bonding capabilities with water due to the acetamide group.
  • Van der Waals forces from the fluorene structure contributing to solubility in non-polar environments.
  • Influence of pH: The solubility may vary under different pH conditions, potentially impacting the ionization of the acetamide group.

In conclusion, the solubility of N-(7-fluoro-9H-fluoren-2-yl)acetamide is a dynamic characteristic that must be evaluated under various conditions to fully understand its behavior in different environments.

Interesting facts

Interesting Facts about N-(7-fluoro-9H-fluoren-2-yl)acetamide

N-(7-fluoro-9H-fluoren-2-yl)acetamide is a fascinating compound that belongs to the family of amides, which are characterized by the presence of a carbonyl group attached to a nitrogen atom. This specific compound presents unique attributes and applications that make it noteworthy in the field of chemistry.

Chemical Structure and Properties

  • Fluorine Substitution: The presence of a fluorine atom, specifically at the 7-position of the fluorenyl moiety, imparts unique electronic characteristics, enhancing the compound's reactivity and potential applications in drug development.
  • Amide Functionality: Amides are pivotal in organic chemistry, often serving as intermediates in the synthesis of a wide array of pharmaceuticals and agrochemicals.
  • Fluorenyl Backbone: The fluorenyl structure is recognized for its stability and ability to participate in π-π stacking interactions, which is significant in materials science and organic electronics.

Applications and Importance

This compound has attracted attention for its potential roles in:

  • Medicinal Chemistry: Compounds with fluorinated substituents often exhibit enhanced biological activity, making them valuable in the development of new therapeutic agents.
  • Material Science: The structural features of N-(7-fluoro-9H-fluoren-2-yl)acetamide can lead to interesting properties in polymer films, luminescent materials, and more.
  • Research in Organofluorine Chemistry: As a fluorinated compound, it contributes significantly to the study of how fluorine atoms affect molecular behavior and interactions.

Conclusion

In summary, N-(7-fluoro-9H-fluoren-2-yl)acetamide serves as an intriguing subject of study due to its chemical structure, potential applications, and the implications of its properties in various fields. Its contributions to medicinal and material sciences underscore the ongoing interest in fluorinated compounds in contemporary chemistry.

Synonyms
343-89-5
N-(7-fluoro-9H-fluoren-2-yl)acetamide
7-Fluoro-2-acetylaminofluorene
7-Fluoro-N-2-acetylaminofluorene
N-2-Acetylamino-7-fluorofluorene
N-(7-Fluorofluoren-2-yl)acetamide
7-Fluoro-2-acetamido-fluorene
Acetamide, N-(7-fluoro-9H-fluoren-2-yl)-
NSC 46525
7-Fluoro-2-acetamidofluorene
BRN 2809479
AI3-50464
ACETAMIDE, N-(7-FLUOROFLUOREN-2-YL)-
DTXSID80187863
4-12-00-03383 (Beilstein Handbook Reference)
NSC-46525
NSC46525
2-ACETAMIDO-7-FLUOROFLUORENE
Acetamide,N-(7-fluoro-9H-fluoren-2-yl)-
CHEMBL84443
74P8LP84VP
SCHEMBL3345432
DTXCID40110354
7-Fluoro-2-(acetylamino)fluorene
WLN: L B656 HHJ EMV1 KF
AKOS024342528
DS-009570
Acetamide, N-(7-fluoro-9H-fluoren-2-yl)-(9CI)