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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
State
State

At room temperature, colchicine is in a solid state. It is known for being relatively stable in its solid form, maintaining integrity under standard conditions.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4370g/mol
Density
1.6600g/cm3
Appearence

Colchicine is a pale yellow, crystalline solid. Its appearance can be described as a fine powder, sometimes found in slightly off-white shades. It is known for its needle-like crystals when purified.

Comment on solubility

Solubility of N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

The solubility of N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is an important characteristic that can influence its applications and effectiveness in various fields. Understanding the solubility properties of this compound involves several key aspects:

  • Polar vs Non-polar: The presence of the amino and acetamide functional groups suggests a potential for polar interactions, which may enhance solubility in polar solvents such as water.
  • Solvent Interaction: The trimethoxy groups contribute to the overall polarity, while the benzo[a]heptalen moiety may result in hydrophobic characteristics. Therefore, solubility can vary significantly depending on the solvent used.
  • Temperature Effects: Temperature also plays a critical role; typically, solubility can increase with elevated temperatures for many organic compounds.
  • pH Dependence: Given the presence of functional groups that can ionize, the solubility may be influenced by the pH of the solution, making it crucial to consider acidity or basicity in various environments.

In summary, while the compound may exhibit solubility in aqueous solutions due to its polar functionalities, its degree of solubility can greatly depend on factors such as solvent nature, temperature, and pH. Understanding these factors is essential for optimizing its use in various applications.

Interesting facts

Interesting Facts about N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is a fascinating compound with a rich tapestry of chemical properties and potential applications.

Key Features:

  • Structural Complexity: The compound features an intricate molecular structure that incorporates a benzo[a]heptaline ring, which is known for its stability and robust chemical characteristics.
  • Amino Group Presence: The presence of the amino group allows for potential interactions in biological systems, which may play a crucial role in various biochemical pathways.
  • Trimethoxy Groups: The trimethoxy substituents may contribute to its solubility properties, helping enhance bioavailability in medicinal applications.

Biological Significance:

This compound is of interest in the field of medicinal chemistry due to its potential pharmacological activities. As researchers explore its therapeutic properties, some notable aspects include:

  • Potential anti-inflammatory effects
  • Possibilities for neuroprotective properties
  • Interest in its application against certain types of cancers

Research Insights:

Current studies may be investigating:

  • The compound's mechanisms of action within biological systems
  • Synergistic effects with other pharmacological agents
  • Optimization of synthetic routes to improve yield and functionality

As a student or a scientist, understanding such a compound provides a broader perspective on the vast world of organic chemistry and its implications in modern medicine. In the quest for new therapies, exploring the myriad of complex molecules like N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide can lead to groundbreaking discoveries that change lives.

Synonyms
Colchiceinamid
Colchiceinamide
Colchicine amide
Colchicamide
Colchicenamide
Colchicamid
3123-89-5
Colchicide, 14-amino-
SKF 3192
COLCHICINE, 10-AMINO-10-DEMETHOXY-
N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
14-Aminocolchicide
Colchicamide (VAN)
Colchiceeinamide
Colchiceeinamide [German]
N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
NSC 403144
BRN 2824077
MFCD25368469
4-14-00-00921 (Beilstein Handbook Reference)
Acetamide, N-(10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
Colchicamide (colchiceinamide)
CHEMBL357889
SCHEMBL12118701
DTXSID00185149
NSC403144
STL530408
AKOS030489333
NSC-403144
Acetamide,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-