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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
State
State

At room temperature, colchicine is in a solid state, specifically as a crystalline powder. It is slightly soluble in water and more soluble in alcohol.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4370g/mol
Density
1.3300g/cm3
Appearence

Colchicine is a pale yellow powder or white to off-white, fine crystalline powder. It is usually odorless and can be sensitive to light when exposed.

Interesting facts

Interesting Facts about N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is a fascinating compound with unique properties and potential applications. Here are some compelling insights about this intriguing molecule:

  • Structural Complexity: This compound features a complex structure, characterized by a benzo[a]heptalen moiety. The integration of a diethylamino group and multiple methoxy functional groups adds to its intriguing architectural layout.
  • Biological Significance: Due to its structural features, compounds like this are often explored for their biological activities. The presence of an amide linkage suggests potential interactions with biological targets, possibly making it a candidate for pharmacological studies.
  • Potential Therapeutic Applications: Compounds with similar frameworks have been studied for their effectiveness in therapeutic areas such as antitumor, anti-inflammatory, and analgesic treatments. This compound’s unique structure may offer novel pathways for drug discovery.
  • Stereochemistry: The (7S) designation indicates its stereochemical configuration, which is crucial in determining its biological activity. As a student or scientist, understanding the impact of stereoisomerism can be pivotal in the field of medicinal chemistry.
  • Research Opportunities: There is a wide-open field for exploring the reactivity of this compound. With its distinct chemical groups, you can investigate how modifications can enhance its properties or explore mechanisms of action.

In summary, N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide stands out not only for its structural complexity but also for its potential impact in medicinal chemistry. As research continues to uncover the biological roles of such compounds, it’s exciting to contemplate the future innovations they may inspire in therapeutic strategies.

Synonyms
10-Demethoxy-10-(diethylamino)colchicine
BRN 3180742
COLCHICINE, 10-DEMETHOXY-10-(DIETHYLAMINO)-
6962-03-4
DTXSID50219887
4-14-00-00924 (Beilstein Handbook Reference)
DTXCID00142378
N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
NSC33690
CHEMBL420597
NSC-33690
STL542372
AKOS002142032
Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3-trimethoxy-