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Colchicine

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Identification
Molecular formula
C22H25NO6S
CAS number
64-86-8
IUPAC name
N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
State
State

Colchicine is found as a solid at room temperature. It is generally not volatile and requires high temperatures to change states.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
413.00
Boiling point (Kelvin)
686.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4380g/mol
Density
1.6600g/cm3
Appearence

Colchicine is a pale yellow powder. It is crystalline in nature and can appear as a solid mass under certain conditions of storage.

Comment on solubility

Solubility of N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

The solubility of N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide represents an intriguing aspect of its chemical behavior. Understanding its solubility can greatly influence its application in various fields, including medicinal chemistry and material sciences. Here are some key points to consider:

  • Polarity: The presence of multiple functional groups, such as the formamide and methoxy groups, enhances the compound's polarity, which tends to improve its solubility in polar solvents like water.
  • Hydrophobic Character: Despite its polar groups, the bulky benzo[a]heptalene structure may impart some hydrophobic characteristics, which can limit solubility in highly polar environments.
  • Solvent Selection: This compound is likely to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol, where both polar and nonpolar interactions can occur.
  • Temperature Effects: Elevated temperatures may increase solubility by providing the energy needed to overcome intermolecular forces.

In summary, the solubility of N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide is influenced by an interplay of its molecular structure and the solvent's properties. Consequently, careful solvent selection is crucial for maximizing its solubility for various applications.

Interesting facts

Interesting Facts about N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

This fascinating compound, often referred to in scientific literature, is notable for its complex structure and potential applications in medicinal chemistry. Here are some compelling insights:

  • Synthetic Challenges: The synthesis of this compound involves intricate organic reactions, showcasing the skill and creativity required in modern chemistry. Its multiple functional groups provide unique challenges for chemists.
  • Biological Activity: Compounds like this one are frequently investigated for their bioactive properties. Research suggests that they may possess antiproliferative and antimicrobial activities, making them of interest in the pharmaceutical industry.
  • Structure-Activity Relationship (SAR): The presence of the trimethoxy and methylsulfanyl groups yields a diverse range of possible interactions within biological systems, influencing how this compound behaves and can be modified for enhanced effectiveness.
  • Potential in Drug Development: Given its structural characteristics and possible biological effects, compounds in this chemical class are often targeted for development as therapeutics, particularly in cancer medicine.
  • Chemical Versatility: The morphed structure allows for various derivatives to be synthesized, paving the way for a wide array of chemical compounds with different properties and potential uses.

In conclusion, N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide exemplifies the intersection of complex organic chemistry and potential therapeutic application, continuing to inspire scientific inquiry and innovation.

Synonyms
N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]formamide
N-((7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)formamide
N-(Formyldeacetyl)thiocolchicine
2731-23-9
COLCHICINE, N-DEACETYL-N-FORMYL-10-THIO-
NSC-373031
NSC 373031
BRN 2786590
D4JNN36GUT
CHEMBL279958
DTXSID601116472
4-14-00-00955 (Beilstein Handbook Reference)
Formamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-