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N-(9-fluorenylidene)acetamide

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Identification
Molecular formula
C15H11NO2
CAS number
562-64-3
IUPAC name
N-(9H-fluoren-2-yl)-N-hydroxy-acetamide
State
State

Under standard conditions, N-(9H-fluoren-2-yl)-N-hydroxy-acetamide exists as a solid.

Melting point (Celsius)
153.50
Melting point (Kelvin)
426.65
Boiling point (Celsius)
545.70
Boiling point (Kelvin)
818.85
General information
Molecular weight
239.26g/mol
Molar mass
239.2630g/mol
Density
1.4120g/cm3
Appearence

N-(9H-fluoren-2-yl)-N-hydroxy-acetamide appears as a white to off-white crystalline solid. The compound is usually available in its pure form, and its crystalline nature can be observed as fine particles or powder.

Comment on solubility

Solubility Overview of N-(9H-fluoren-2-yl)-N-hydroxy-acetamide (C15H11NO2)

N-(9H-fluoren-2-yl)-N-hydroxy-acetamide exhibits intriguing solubility characteristics due to its unique molecular structure. Understanding its solubility is essential for applications in various fields, especially in pharmaceuticals and material science.

Solubility Characteristics

The solubility of N-(9H-fluoren-2-yl)-N-hydroxy-acetamide can be influenced by several factors:

  • Polarity: The presence of the -OH group enhances the compound's polarity, which may aid in its solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl group enables potential hydrogen bonding with solvents, further facilitating solubility.
  • Size and Structure: The large fluorenyl moiety may hinder solubility in certain non-polar solvents due to steric hindrance.

In general:

  • Good solubility: Often observed in dimethyl sulfoxide (DMSO) and other polar aprotic solvents.
  • Poor solubility: Typically less soluble in non-polar solvents like hexane or cyclohexane.

Researchers often note that these solubility attributes can be critical, as they determine the compound's utility in different chemical environments. To enhance solubility, adjustments in solvent choice or the incorporation of co-solvents may be employed. As with many compounds, understanding the solubility profile allows chemists to optimize conditions for reactions and formulations.

Interesting facts

Interesting Facts about N-(9H-fluoren-2-yl)-N-hydroxy-acetamide

N-(9H-fluoren-2-yl)-N-hydroxy-acetamide, often referred to simply as FNHA, is a fascinating compound with a variety of applications and properties that make it intriguing for both chemists and researchers alike. Here are some standout facts about this compound:

  • Structural Robustness: The presence of the fluorenyl group contributes to its stability and unique structural characteristics, making FNHA a subject of interest in organic synthesis and pharmaceuticals.
  • Versatile Applications: N-(9H-fluoren-2-yl)-N-hydroxy-acetamide is noted for its role in medicinal chemistry, particularly in the development of compounds with potential antimicrobial and anticancer properties.
  • Inhibition Mechanisms: This compound has been studied for its ability to inhibit specific enzymatic activities, which is crucial for pathways involved in various diseases.
  • Research and Development: New methods of synthesis and modification of FNHA are continually being explored, enhancing its efficacy and expanding its possible uses in drug design.
  • Fluorene Derivatives: As a derivative of fluorene, which is a polycyclic aromatic hydrocarbon, FNHA shares properties with other compounds in this family, making it an interesting analog for further studies on aromaticity and reactivity.

Researchers continue to explore the implications of N-(9H-fluoren-2-yl)-N-hydroxy-acetamide in various scientific fields. As one study puts it, “Its multifaceted nature opens doors to innovations in therapeutics and material science.”
With ongoing research, FNHA could potentially lead to breakthroughs that enhance our understanding of chemistry and improve public health outcomes.

Synonyms
N-Hydroxy-2-acetamidofluorene
53-95-2
Hydroxyacetylaminofluorene
N-Hydroxy-2-acetylaminofluorene
Nohfaa
N-(9H-Fluoren-2-yl)-N-hydroxyacetamide
N-Hydroxy-aaf
2-(N-Hydroxyacetamido)fluorene
N-Hydroxy-2-faa
Fluorenyl-2-acethydroxamic acid
Acetamide, N-9H-fluoren-2-yl-N-hydroxy-
2-(N-Acetylhydroxylamino)fluorene
N-Fluoren-2-ylacetohydroxamic acid
N-2-Fluorenyl-N-hydroxyacetamide
N-HYDROXY-2-(ACETYLAMINO)FLUORENE
N-Hydroxy-2-acetaminofluorene
N-Hydroxy-N-acetyl-2-aminofluorene
Acetohydroxamic acid, N-fluoren-2-yl-
N-Hydroxy-N-2-fluorenylacetamide
2-Hydroxyacetylaminofluorene
N-Hydroxy acetylaminofluorene
N-Hydroxy-acetylaminofluorene
N-Acetyl-N-2-fluorenylhydroxylamine
N-Hydroxy-N-(2-fluorenyl)acetamide
CCRIS 338
N-Hydroxy-2-fluorenylacetamide
N-9H-Fluoren-2-yl-N-hydroxyacetamide
2-N-Hydroxy-acetylaminofluorene
Acetamide, N-hydroxy-N-(2-fluorenyl)-
UNII-6AGD02HUQC
6AGD02HUQC
NSC 46522
BRN 2654276
CHEBI:17931
AI3-50466
NSC-46522
N-9H-Fluoren-2-yl-N-hydroxy-acetamide
N-(9H-Fluoren-2-yl)-N-hydroxy-acetamide
DTXSID2020719
N-2-Fluorenylacetohydroxamic acid
N-2-FLUORENYLACETOHYDROXAMICACID
HYDROXY-2-ACETYLAMINOFLUORENE, N-
ACETAMIDE, N-FLUOREN-2-YL-N-HYDROXY-
Hydroxyfluorenylacetamide
n-ho-aaf
N Hydroxy 2 acetamidofluorene
Acetamide, N-fluoren-2-yl-N-hydroxy
starbld0036706
DTXCID60719
SCHEMBL637635
CHEMBL284464
NCI-C03349
WLN: L B656 HHJ ENQV1
AAA05395
NSC46522
MFCD00869474
AKOS040767612
Acetamide,n-9h-fluoren-2-yl-n-hydroxy-
DS-009625
N-FLUOREN-2-YL-ACETOHYDROXAMIC ACID
N-(9H-Fluoren-2-yl)-N-hydroxyacetamide #
NS00115893
C03954
Q5955515