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Phenacetin

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Identification
Molecular formula
C10H13NO2
CAS number
62-44-2
IUPAC name
N-acetyl-N-(2-phenylethyl)acetamide
State
State

At room temperature, phenacetin is in a solid state, usually in the form of crystalline powder. It is stable under normal conditions and remains solid until it reaches its melting point.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
515.00
Boiling point (Kelvin)
788.15
General information
Molecular weight
179.22g/mol
Molar mass
179.2160g/mol
Density
1.2400g/cm3
Appearence

Phenacetin appears as a white or colorless crystalline solid. The compound is typically in the form of fine, odorless crystals or a crystalline powder. It is known for its distinctive crystalline structure and typically maintains a solid form under standard conditions.

Comment on solubility

Solubility of N-acetyl-N-(2-phenylethyl)acetamide

N-acetyl-N-(2-phenylethyl)acetamide, a compound with both hydrophilic and hydrophobic characteristics, showcases variable solubility depending on its environment and conditions. Typically, the solubility of this compound can be discussed in the following contexts:

  • Water Solubility: The presence of the acetamide group suggests that it may exhibit some degree of solubility in water. However, the larger phenylethyl group could hinder solubility, leading to a limited dispersal in aqueous solutions.
  • Solvents: This compound is generally more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO) due to its non-polar characteristic and hydrophobic interactions.
  • Temperature Influence: The solubility can increase with temperature. As temperature rises, solvation effects become more pronounced, which may enhance the compound's ability to dissolve in a given solvent.

In summary, while N-acetyl-N-(2-phenylethyl)acetamide may show modest solubility in water, its greater affinity for organic solvents makes it more suitable for non-aqueous systems. Understanding these solubility characteristics is crucial for applications ranging from pharmaceuticals to chemical synthesis.

Interesting facts

Interesting Facts about N-acetyl-N-(2-phenylethyl)acetamide

N-acetyl-N-(2-phenylethyl)acetamide, often abbreviated as NAPE, is a fascinating compound that bridges the realms of organic chemistry and pharmacology. Below are some intriguing insights about this compound:

  • Structural Significance: NAPE features a unique symmetrical structure that incorporates both an acetyl and a 2-phenylethyl group, which contributes to its chemical reactivity and biological activity.
  • Pharmacological Potential: Research suggests that this compound may exhibit biological activity that could be relevant in therapeutic applications, particularly in pain management and neurological research.
  • Possibility of Derivatives: The presence of the acetyl group allows for the potential derivation of various analogs, which may enhance specific properties or modulate activity for drug development.
  • Applications in Research: NAPE is often studied in the context of receptor interactions, as it may play a role in modulating neurotransmitter activity and could pave the way for new insights in neuropharmacology.
  • Historical Context: Compounds containing amide functional groups have long been of interest in organic synthesis and medicinal chemistry, making NAPE a part of a rich tapestry of research and discovery.

In summary, N-acetyl-N-(2-phenylethyl)acetamide stands as a testament to the intricate relationship between chemical structure and biological functionality. Its exploration could lead to enhanced understanding and potentially novel applications in various fields of science.

Synonyms
N-Acetyl-N-(2-phenylethyl)acetamide
27179-64-2
DTXSID90181650
RefChem:363118
DTXCID30104141