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N-acetylacetamide

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Identification
Molecular formula
C4H9NO2
CAS number
121-45-9
IUPAC name
N-acetylacetamide
State
State

N-acetylacetamide is typically found as a solid at room temperature.

Melting point (Celsius)
81.00
Melting point (Kelvin)
354.15
Boiling point (Celsius)
237.00
Boiling point (Kelvin)
510.15
General information
Molecular weight
115.13g/mol
Molar mass
115.1310g/mol
Density
1.0890g/cm3
Appearence

N-acetylacetamide occurs as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-acetylacetamide

N-acetylacetamide, also known by its chemical formula C4H7NO2, exhibits interesting solubility properties that are worth exploring. Generally, this compound is:

  • Soluble in Water: N-acetylacetamide is moderately soluble in water due to the presence of polar functional groups that can engage in hydrogen bonding.
  • Soluble in Organic Solvents: It is also soluble in a variety of organic solvents like ethanol and acetone, which allows it to be used in different chemical applications.
  • Limited Solubility in Non-Polar Solvents: On the other hand, its solubility decreases significantly in non-polar solvents like hexane, reflecting the compound's polar nature.

When discussing solubility, it is essential to consider the following factors:

  1. The nature of the solvent (polar vs. non-polar)
  2. The temperature of the solution
  3. The presence of other solutes or impurities

In summary, N-acetylacetamide is generally soluble in polar solvents and demonstrates versatility in both aqueous and organic environments, making it a compound of significant interest in various fields of chemistry.

Interesting facts

Interesting Facts about N-Acetylacetamide

N-acetylacetamide, also known as acetylacetamide, is a fascinating compound that has garnered attention in various scientific fields due to its unique properties and potential applications. Here are some intriguing aspects of this compound:

  • Chemical Structure: The compound features an amide functional group, which contributes to its versatility in chemical reactions and applications.
  • Pharmaceutical Implications: N-acetylacetamide has been studied for its potential in medicinal chemistry, particularly in the synthesis of analgesic and anti-inflammatory agents.
  • Biochemical Relevance: It is a structural analog of acetaminophen, which adds to its relevance in studies exploring mechanisms of action and the development of novel therapeutic agents.
  • Research Applications: Scientists explore its use in various research areas, including organic synthesis and biochemical assays, due to its effective functionality in reactions.
  • Temperature Stability: N-acetylacetamide displays stability across a range of temperatures, making it a reliable compound for various laboratory experiments.

Quotes from experienced chemists often emphasize the importance of such compounds in exploring new pharmaceutical developments: "Every small modification in the functional groups of a compound can lead to significant differences in activity." This highlights the critical role that N-acetylacetamide may play in the ongoing search for more effective therapeutic agents.

Overall, N-acetylacetamide represents a compelling area of study for chemists and students alike, offering opportunities for innovation in both academic and applied research settings.

Synonyms
DIACETAMIDE
N-Acetylacetamide
Acetamide, N-acetyl-
Diacetylamine
Bisacetylamine
N-Acetyl-acetamide
CH3C(O)NHC(O)CH3
EINECS 210-910-1
DTXSID10211549
NSC 405639
DTXCID90134040
210-910-1
inchi=1/c4h7no2/c1-3(6)5-4(2)7/h1-2h3,(h,5,6,7
zsbdpriwbyhiaf-uhfffaoysa-n
625-77-4
n-acetyl acetamide
NSC-405639
Diacetamide; N-Acetylacetamide; Diacetylamine; NSC 405639
N- Acetylacetamide
Diacetamide, 97%
M3GE4E3PRK
NCIOpen2_003809
SCHEMBL97089
CHEMBL18986
QSPL 004
SCHEMBL26163222
MFCD00008679
NSC405639
AKOS000121396
AS-56342
DB-030109
DB-080786
CS-0188389
NS00022553
D97387