Skip to main content

N-allyloxy-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-imine

ADVERTISEMENT
Identification
Molecular formula
C18H15Cl2N3O
CAS number
40054-69-1
IUPAC name
N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine
State
State
At room temperature, this compound is a crystalline solid. It exhibits slight hygroscopic properties and light sensitivity due to its chlorine content.
Melting point (Celsius)
85.00
Melting point (Kelvin)
358.15
Boiling point (Celsius)
469.00
Boiling point (Kelvin)
742.15
General information
Molecular weight
367.23g/mol
Molar mass
367.2340g/mol
Density
1.3550g/cm3
Appearence

N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine appears as a crystalline solid with a distinctive, light yellow coloration. Due to the presence of chlorine atoms, its color is deeper than its non-halogenated counterparts in the benzodiazepine family.

Comment on solubility

Solubility of N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine

The solubility of N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine can be quite complex due to its intricate structure and the presence of various functional groups. Understanding its solubility characteristics is essential for applications in pharmaceuticals and materials science. Here are some key points to consider:

  • Polarity: The compound possesses both polar and nonpolar regions, which suggests it may have limited solubility in water, a polar solvent, while being more soluble in organic solvents like chloroform or methanol.
  • Hydrogen Bonding: The presence of nitrogen and oxygen atoms allows for the potential formation of hydrogen bonds, which can enhance solubility in polar solvents to some extent.
  • Impact of Chlorine Substituents: The presence of chlorine atoms can affect the compound's hydrophobicity, further influencing its solubility profile.
  • pH Dependence: The solubility may also vary with changes in pH, especially in biological systems, where it could be highly relevant for drug delivery systems.

In summary, while N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine is likely to have low to moderate solubility in water, its solubility can be significantly influenced by the choice of solvent and environmental conditions. Therefore, thorough solubility studies are recommended to fully understand its behavior in various applications.

Interesting facts

Interesting Facts About N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine

N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine is a fascinating compound that falls under the category of benzodiazepines. Known for their significant pharmacological effects, benzodiazepines are widely studied in medicinal chemistry and pharmacology.

Key Characteristics

  • Pharmacological Activity: Benzodiazepines are primarily recognized for their anxiolytic, sedative, and hypnotic properties. This compound, in particular, may exhibit interactions that could affect neurotransmitter pathways, particularly with GABA receptors.
  • Structural Features: The unique structure of this compound includes a benzodiazepine backbone with an allyloxy group and a chloro substituent, which may influence its binding affinity and specificity.
  • Potential Applications: Research suggests that modifications to the benzodiazepine structure can lead to novel therapeutic agents. Therefore, this compound could pave the way for the development of new drugs in anxiety treatment or other neuropsychiatric disorders.

Research and Development

The exploration of such compounds often focuses on their structure-activity relationship (SAR), allowing chemists to understand how specific alterations in the molecular architecture affect the resulting biological activity. For instance, substituents like chloro groups can enhance potency or alter metabolism.

Quote from Chemistry

As stated in a prominent research article, "The design of novel benzodiazepines requires careful consideration of their electronic and steric properties, as these factors significantly contribute to their pharmacological profiles."

In conclusion, N-allyloxy-7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-amine exemplifies the intricate design and potential benefits of benzodiazepine derivatives. With ongoing research, compounds like this may significantly impact therapeutic strategies in neurology and psychiatry.

Synonyms
ULDAZEPAM
28546-58-9
Uldazepamum
VAE9C0350C
U-31,920
DTXSID70182766
U 31920
U-31920
2-((Allyloxy)amino)-7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine
RefChem:933777
DTXCID10105257
2-(allyloxy)amino 7-chloro-5-(o-chlorophenyl)-3H-1, 4-benzodiazepine
3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-(2-propenyloxy)-
U31920
7-chloro-5-(2-chlorophenyl)-N-prop-2-enoxy-3H-1,4-benzodiazepin-2-amine
U 31,920
Uldazepam [USAN:INN]
Uldazepamum [INN-Latin]
UNII-VAE9C0350C
ULDAZEPAM [INN]
Uldazepam (USAN/INN)
ULDAZEPAM [USAN]
SCHEMBL115564
CHEMBL2105584
SCHEMBL29516012
CHEBI:229868
DBA54658
AKOS040740953
DA-78762
HY-100264
CS-0018415
NS00121143
D06263
Q7878818
2-(Allyloxy)amino 7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepine