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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
N-benzhydryl-2-chloro-N-ethyl-ethanamine
State
State

At room temperature, diphenhydramine is in a solid state, generally as a crystalline powder. In pharmaceutical forms like tablets and capsules, it remains solid until metabolized within the body.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
158.00
Boiling point (Kelvin)
431.15
General information
Molecular weight
255.35g/mol
Molar mass
255.3530g/mol
Density
1.0000g/cm3
Appearence

Diphenhydramine is typically encountered as a white crystalline powder, though it may also appear in the form of white tablets or capsules when prepared for pharmaceutical purposes. The powder can be slightly hygroscopic and tends to have a mild amine-like odor.

Comment on solubility

Solubility of N-benzhydryl-2-chloro-N-ethyl-ethanamine

N-benzhydryl-2-chloro-N-ethyl-ethanamine, a compound with a complex structure, exhibits intriguing solubility characteristics. The solubility of this compound can be influenced by a variety of factors:

  • Polarity: Due to the presence of an amine group, this compound is likely polar, which can enhance its solubility in polar solvents.
  • Hydrophobic interactions: The benzhydryl group contributes significant hydrophobic character, potentially decreasing solubility in water while increasing it in organic solvents.
  • Temperature: Generally, an increase in temperature can increase solubility for many organic compounds, including this one.

It is important to note the role of functional groups as well:

  1. Chloro group: This substituent could impact solubility by influencing intermolecular interactions.
  2. Ethyl group: The ethyl group may assist in solubility within organic solvents due to its hydrophobic properties.

In summary, while the specific solubility data of N-benzhydryl-2-chloro-N-ethyl-ethanamine may vary by conditions, it can be expected to have:

  • Good solubility in organic solvents such as ethanol and chloroform.
  • Limited solubility in water due to its hydrophobic regions.

Understanding these solubility trends can assist in further applications and utilization of N-benzhydryl-2-chloro-N-ethyl-ethanamine in scientific practices.

Interesting facts

Interesting Facts about N-benzhydryl-2-chloro-N-ethyl-ethanamine

N-benzhydryl-2-chloro-N-ethyl-ethanamine is a fascinating compound often explored in the field of medicinal chemistry. Its unique structure allows it to interact with various biological pathways, making it a subject of interest for drug development. Here are some intriguing facts about this compound:

  • Pharmacological Applications: This compound is known for its potential use in pharmaceuticals, particularly as a precursor for certain therapeutic agents.
  • Structural Properties: The presence of the benzhydryl group enhances the lipophilicity, which can improve the overall biological activity and pharmacokinetics of the molecule.
  • Chirality and Stereochemistry: The compound may exhibit chirality, leading to different biological activities between its enantiomers, which is an important factor in medicinal chemistry.
  • Research Significance: Studies have shown this compound’s potential in the development of neurological agents, highlighting its relevance in treating neurodegenerative diseases.
  • Safety and Handling: As with many chemical compounds, proper safety protocols must be observed when handling N-benzhydryl-2-chloro-N-ethyl-ethanamine to minimize health risks.

In summary, N-benzhydryl-2-chloro-N-ethyl-ethanamine presents a captivating interplay between chemistry and biology. As researchers continue to explore its properties and implications, this compound holds promising prospects for future scientific advancements. Its multifaceted nature underscores the importance of understanding chemical interactions at a molecular level, which can lead to significant breakthroughs in medicine.