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N-Benzhydrylidene-4-aminopyridine-4-carboxamide

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Identification
Molecular formula
C19H15N3O
CAS number
5118-13-8
IUPAC name
N-(benzhydrylideneamino)pyridine-4-carboxamide
State
State

At room temperature, N-Benzhydrylidene-4-aminopyridine-4-carboxamide is typically in a solid state. It is not very volatile and remains stable in typical environmental conditions when properly stored.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.00
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.00
General information
Molecular weight
278.33g/mol
Molar mass
278.3340g/mol
Density
1.2000g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It may display slight variations in coloration depending on the purity and specific sample, ranging from white to slightly yellowish.

Comment on solubility

Solubility of N-(benzhydrylideneamino)pyridine-4-carboxamide

N-(benzhydrylideneamino)pyridine-4-carboxamide, a compound featuring both aromatic and amide functionalities, presents interesting solubility characteristics. Understanding the solubility of this compound is crucial for its application in various fields, including medicinal chemistry and material science. Here are some key points:

  • Solvent Dependency: The solubility of N-(benzhydrylideneamino)pyridine-4-carboxamide may vary widely depending on the solvent used. Generally, it is expected to be more soluble in polar solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).
  • Hydrogen Bonding: The presence of the –CO(NH)– group in its structure allows for the formation of hydrogen bonds, which can enhance solubility in polar solvents.
  • Functional Group Influence: The interaction of the aromatic benzhydryl moiety with various solvents can lead to non-polar behavior in non-polar solvents like benzene or hexane, reducing solubility in these media.
  • Temperature Effect: Typically, an increase in temperature may lead to increased solubility for many organic compounds, potentially including N-(benzhydrylideneamino)pyridine-4-carboxamide. This is worth considering in experimental setups.

In conclusion, while the solubility of N-(benzhydrylideneamino)pyridine-4-carboxamide can be enhanced in appropriate solvents, it is crucial to consider the specific conditions and the solvent environment to fully understand its solubility profile.

Interesting facts

Interesting Facts about N-(benzhydrylideneamino)pyridine-4-carboxamide

N-(benzhydrylideneamino)pyridine-4-carboxamide, a compound that bridges both the realms of organic synthesis and medicinal chemistry, presents a fascinating profile due to its unique structural characteristics.

Chemical Structure

This compound features a complex structure that includes:

  • Pyridine ring: A six-membered aromatic ring that contributes to the compound's electron-withdrawing properties.
  • Amine functionality: The presence of an amino group plays a crucial role in interactions with biological targets.
  • Benzylic moiety: The benzhydryl group significantly enhances the compound's lipophilicity, which is essential in drug design.

Applications in Medicine

Research has illustrated the potential of N-(benzhydrylideneamino)pyridine-4-carboxamide in various applications:

  • Anticancer Activity: Preliminary studies suggest efficacy against several cancer cell lines, positioning it as a candidate for further pharmacological development.
  • Antimicrobial Properties: The compound displays antimicrobial activity, making it a subject of interest in combating resistant bacteria.
  • Inflammation Modulation: Its ability to modulate inflammatory pathways indicates potential therapeutic uses in conditions such as arthritis.

Research Insights

As a scientist exploring this compound, one might find noteworthy insights in its:

  • Reactivity: The reactive amine and carbonyl groups allow for diverse synthetic modifications, enhancing its functionality.
  • Biological Interactions: Understanding how this compound interacts with protein targets can lead to the development of effective treatments.

In conclusion, N-(benzhydrylideneamino)pyridine-4-carboxamide exemplifies the beauty of organic chemistry and its impact on medicinal applications. Its rich structural features and myriad of potential biological activities make it a promising subject for further study.

Synonyms
ISONICOTINIC ACID, (DIPHENYLMETHYLENE)HYDRAZIDE
4813-14-3
BRN 0252989
Isonicotinylhydrazone de la benzophenone [French]
Isonicotinylhydrazone de la benzophenone
DTXSID70197431
4-22-00-00578 (Beilstein Handbook Reference)
DTXCID80119922
CHEMBL2262371
STL482565
AKOS000519502
(e)-N'-diphenylmethylene isonicotinohydrazide
N'-(diphenylmethylidene)pyridine-4-carbohydrazide
SR-01000367447
SR-01000367447-1