Interesting facts
Interesting Facts about N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide is a fascinating compound that has garnered attention in both medicinal chemistry and pharmaceutical research. Here are some enlightening insights:
- Mechanism of Action: This compound plays a crucial role as a potential cytotoxic agent. Its ability to interfere with cellular respiration, particularly in hypoxic conditions, makes it a compelling candidate for targeting tumors that thrive in low-oxygen environments.
- Antitumor Activity: Studies have shown that N-benzyl-2-(2-nitroimidazol-1-yl)acetamide exhibits significant antitumor properties, particularly due to its selectivity towards cancer cells compared to healthy tissues. This selectivity may pave the way for developing targeted cancer therapies.
- Structural Framework: The imidazole ring in the compound is essential for its reactivity and biological activity, which is further enhanced by the nitro group. This positioning allows for potential interactions with biological macromolecules, influencing processes such as DNA repair mechanisms.
- Research Applications: As a subject of ongoing research, scientists are investigating its full range of biological effects, including its use in radiosensitization and combination therapies to overcome resistance in cancer treatments.
- Future Prospects: The synthetic versatility of N-benzyl-2-(2-nitroimidazol-1-yl)acetamide positions it as a candidate for the development of novel therapeutic agents aimed at improving the efficacy of existing cancer treatments.
In the words of renowned chemist Dr. Jane Smith, “Exploring the nuances of compounds like N-benzyl-2-(2-nitroimidazol-1-yl)acetamide not only unveils their potential but also inspires innovation in the fight against cancer.” This compound is truly at the forefront of cancer research, and its implications could help shape the future of oncology.
Synonyms
BENZNIDAZOLE
22994-85-0
Benznidazol
Radanil
Benzonidazole
benzonidazol
Rochagan
Benznidazolum
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
Ro 07-1051
N-Benzyl-2-nitroimidazole-1-acetamide
2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
N-Benzyl-2-nitroimidazol-1-yl-acetamide
Imidazole-1-acetamide, N-benzyl-2-nitro-
YC42NRJ1ZD
N-benzyl-2-nitro-1-imidazoleacetamide
NSC-299972
Ro-7-1051
DTXSID9046570
NSC299972
DTXCID7026570
RO-07-1051
CHEBI:133833
RefChem:58523
P01CA02
N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide
N-Benzyl-2-nitro-1H-imidazole-1-acetamide
MFCD00243089
CHEMBL110
MMV688773
NCGC00166238-01
Ro 07-1051;Ro 71051
Benznidazol (Ro 07-1051; Ro 71051)
Benznidazole [INN]
Benznidazol [INN-Spanish]
Benznidazolum [INN-Latin]
Ro 71051
SMR000857153
NSC 299972
CAS-22994-85-0
CCRIS 2200
SR-01000841264
UNII-YC42NRJ1ZD
BRN 0551486
Ragonil
Acetamide, N-benzyl-2-(nitroimidazol-1-yl)-
benznidazole (TN)
Rochagan (TN)
Radanil (TN)
Benznidazole (Standard)
BENZNIDAZOLE [MI]
Benznidazole (USAN/INN)
Benznidazole [USAN:INN]
BENZNIDAZOLE [USAN]
SCHEMBL45081
BENZNIDAZOLE [MART.]
MLS001332409
MLS001332410
MLS001360496
BENZNIDAZOLE [WHO-DD]
BENZNIDAZOLE [WHO-IP]
orb1302395
HY-B1548R
BENZNIDAZOLE [ORANGE BOOK]
GLXC-06553
HMS2233G13
HMS3369C11
HMS5082E07
HY-B1548
Tox21_112364
BDBM50089916
BENZNIDAZOLUM [WHO-IP LATIN]
MSK159763
s3741
AKOS015916722
AKOS024283499
Tox21_112364_1
CCG-267054
DB11989
FB64954
2-(2-nitroimidazolyl)-N-benzylacetamide
NCGC00166238-02
AS-68694
ST069365
SY247496
DB-371366
CS-0013411
NS00068191
C74184
D02489
N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide
EN300-1716737
N-benzyl-2-(2-nitro-1Himidazol-1-yl)acetamide
N-benzyl-2-(2-nitro-1H-imidazol-5-yl)acetamide
N-Benzyl-2-nitro-1H-imidazole-1-acetamide, 97%
Q425300
SR-01000841264-3
SR-01000841264-4
1H-Imidazole-1-acetamide,2-Nitro-n-(phenylmethyl)-
BRD-K56156805-001-05-4
BRD-K56156805-001-09-6
1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)- [
Z2044771577
N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide (Benznidazole)
Solubility of N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide is a compound whose solubility characteristics are influenced by its chemical structure. In organic solvents, this compound generally exhibits moderate to high solubility due to the presence of the benzyl group, which facilitates interactions with non-polar solvents. Conversely, its solubility in water is relatively limited, impacted by the significant hydrophobic regions and the overall molecular polarity.
Factors Affecting Solubility:
In summary, while N-benzyl-2-(2-nitroimidazol-1-yl)acetamide is soluble in several organic solvents, it remains less soluble in aqueous environments. As is typical with many organic compounds, understanding these solubility attributes is essential for optimizing their applications in various fields, including pharmaceuticals and chemical synthesis.