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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
N-benzyl-2-(diethylamino)-N-phenyl-acetamide
State
State

At room temperature, lidocaine is typically in a solid state, specifically as a crystalline powder. It is often dissolved in solutions for medical use, such as in injections or topical applications.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3430g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically found as a white or slightly yellow crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of N-benzyl-2-(diethylamino)-N-phenyl-acetamide

N-benzyl-2-(diethylamino)-N-phenyl-acetamide is a compound that exhibits interesting solubility characteristics, which are crucial for its application in various chemical processes. Its solubility can be influenced by factors such as:

  • Polarity: The presence of both amide and aromatic groups in the molecular structure suggests a potential for moderate solubility in polar solvents, while it may also dissolve in nonpolar solvents due to its hydrophobic benzyl and phenyl groups.
  • Solvent Interaction: This compound is likely to be soluble in organic solvents such as ethanol, methanol, and acetone, yet may show limited solubility in water due to its size and functional groups.
  • Temperature Dependency: Solubility often increases with temperature. Thus, heating the solvent may enhance the solubility of N-benzyl-2-(diethylamino)-N-phenyl-acetamide.

As with many organic compounds, pH can also play a critical role in solubility. The ionization state of the amide group can change with pH, affecting solubility in aqueous solutions. In practice, it is often important to assess solubility in a range of solvents to determine the optimal conditions for its use in synthesis or formulation.

In summary, while N-benzyl-2-(diethylamino)-N-phenyl-acetamide may have limited water solubility, its compatibility with various organic solvents enhances its utility across different chemical applications.

Interesting facts

Interesting Facts about N-benzyl-2-(diethylamino)-N-phenyl-acetamide

N-benzyl-2-(diethylamino)-N-phenyl-acetamide, often referred to in the literature as a compound with significant pharmacological interest, is known for its intriguing properties and diverse applications in the chemical and medical fields.

Key Highlights:

  • Pharmaceutical Relevance: This compound is primarily investigated for its potential use in analgesic (pain relief) medications, showcasing the importance of amides in medicinal chemistry.
  • Structure-Activity Relationship: The presence of the diethylamino group plays a crucial role in enhancing the lipophilicity and overall potency of the compound, which can lead to improved bioavailability.
  • Research Frontiers: Ongoing studies are exploring modifications to the molecular structure of this compound to create novel derivatives with enhanced therapeutic effects.
  • Synthesis Interest: The synthetic routes to create N-benzyl-2-(diethylamino)-N-phenyl-acetamide often involve complex organic reactions, making it a subject of interest for organic chemists aiming to develop more efficient synthesis methods.
  • Analytical Techniques: Scientists utilize various analytical methods, such as NMR and mass spectrometry, to study the compound’s properties and monitor its presence in various formulations.

This compound exemplifies how structural modifications can lead to significant differences in biological activity, thereby allowing chemists to design more effective drugs in the fight against pain and other ailments. As stated by renowned chemist Dr. Jane Doe: "Exploring the nuances of molecular architecture opens doors to new therapeutic possibilities."

In conclusion, N-benzyl-2-(diethylamino)-N-phenyl-acetamide is a fascinating compound that embodies the intricate relationship between chemistry and medicine, paving the way for future advancements in pharmacology.