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Ibuprofen

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Identification
Molecular formula
C13H18O2
CAS number
15687-27-1
IUPAC name
N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide
State
State

At room temperature, ibuprofen is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
75.00
Melting point (Kelvin)
348.00
Boiling point (Celsius)
149.00
Boiling point (Kelvin)
422.00
General information
Molecular weight
206.28g/mol
Molar mass
206.2840g/mol
Density
1.1750g/cm3
Appearence

Ibuprofen appears as a white to off-white crystalline powder. It is typically odorless or may have a faint characteristic odor and is known for its clear, slightly acidic aspect.

Comment on solubility

Solubility of N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide

The solubility of N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide can be influenced by several factors, making it an interesting compound to study in this regard. Here are some important points to consider:

  • Polarity: The presence of various functional groups in the compound, such as the hydroxyl group, contributes to its overall polarity. This could enhance its solubility in polar solvents, such as water.
  • Hydrogen Bonding: The hydroxyl group allows N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide to participate in hydrogen bonding, which can increase solubility in polar environments.
  • Solvent Effects: The solubility may vary in non-polar solvents due to the hydrophobic isopropyl and benzyl groups. This indicates that N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide may exhibit greater solubility in organic solvents compared to linear aliphatic solvents.
  • Temperature Dependence: As with many organic compounds, solubility can be temperature-dependent. Increased temperatures often enhance solubility, particularly in solid forms.
  • Practical Implications: Understanding its solubility is crucial for applications in pharmaceuticals, as this will dictate formulation choices and efficacy of delivery in bioactive environments.

In conclusion, while theoretical predictions can offer insights, empirical testing remains vital to ascertain the solubility profile of this specific compound in various solvents.

Interesting facts

Interesting Facts about N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide

N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide is a fascinating compound that showcases the intricate world of organic chemistry. This compound belongs to the amide family and highlights the fascinating interactions of aromatic rings and functional groups in its structure.

Key Highlights:

  • Structural Complexity: The compound contains multiple functional groups, making it a rich subject for study in medicinal chemistry.
  • Potential Applications: Its unique structure might suggest potential applications in pharmaceuticals, particularly in the synthesis of compounds with analgesic or anti-inflammatory properties.
  • Hydroxyl Influence: The presence of the hydroxyl group (-OH) can significantly influence the compound's reactivity and interactions, potentially leading to interesting catalytic properties.

This compound exemplifies how minor changes in molecular structure can lead to vastly different chemical properties. For example, the introduction of the isopropyl group can enhance lipophilicity, which may affect the compound's behavior in biological systems.

Moreover, the combination of the benzyl group and the amide functional group illustrates the fascinating interplay of aromaticity and hydrogen bonding, which can lead to interesting supramolecular chemistry phenomena.
These concepts are not only crucial for students and researchers but also ignite innovative thinking in drug discovery and material science.

As a study subject, N-benzyl-2-hydroxy-3-isopropyl-6-methyl-benzamide embodies the principle that every molecule tells a story, offering insights into the profound link between structure and function in chemistry.

Synonyms
BRN 2657112
N-Benzyl-3-hydroxy-p-cymene-2-carboxamide
p-CYMENE-2-CARBOXAMIDE, N-BENZYL-3-HYDROXY-
N-Benzyl-3-isopropyl-6-methylsalicylamide
3893-89-8
DTXSID40192216
4-12-00-02302 (Beilstein Handbook Reference)
DTXCID50114707