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N-(Benzyl(phenylamino)methyl)-4,5-dihydro-1H-imidazole

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Identification
Molecular formula
C18H21N3
CAS number
[CAS Number not available]
IUPAC name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
State
State

At room temperature, N-(Benzyl(phenylamino)methyl)-4,5-dihydro-1H-imidazole is generally a solid. Like many organic compounds, its solid state is due to the molecular interactions present within its crystalline structure.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
480.20
Boiling point (Kelvin)
753.35
General information
Molecular weight
295.39g/mol
Molar mass
295.3900g/mol
Density
1.1590g/cm3
Appearence

N-(Benzyl(phenylamino)methyl)-4,5-dihydro-1H-imidazole appears as a white or off-white crystalline powder. Its structural characteristics influence its appearance, typically resulting in a uniform texture that is typical of crystalline powders.

Comment on solubility

Solubility of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

The solubility of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline (C18H21N3) can be understood through a variety of factors related to its chemical structure. This compound incorporates both aromatic and heterocyclic components, which can significantly impact its solubility in various solvents.

  • Polarity: The presence of an imidazole ring introduces a degree of polarity, which may enhance solubility in polar solvents, such as water, to some extent.
  • Hydrophobic characteristics: The benzyl and aniline parts of the structure are relatively hydrophobic, suggesting better solubility in organic solvents like ethanol or DMSO.
  • Intermolecular interactions: Potential hydrogen bonding between the imidazole nitrogen and solvent molecules can also influence the solubility profile.

In general, it's expected that N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline might exhibit better solubility in non-polar to slightly polar solvents compared to highly polar solvents. However, experimental validation is essential to determine the precise solubility in different environments, given the complex interactions at play.

Interesting facts

Interesting Facts About N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline is a fascinating compound with several noteworthy attributes that make it significant in both chemistry and pharmacology.

Structural Insights

This compound features a unique structure that includes:

  • Benzyl Group: The presence of the benzyl group enhances its lipophilicity, potentially affecting how the compound interacts with biological membranes.
  • Imidazole Ring: The imidazole structure is commonly found in many biologically active molecules, including histidine and certain neurotransmitters, revealing its importance in physiological processes.

Biological Relevance

The imidazole moiety in this compound opens avenues for research in medicinal chemistry. Compounds with imidazole rings:

  • Exhibit a range of biological activities.
  • Serve as critical components in enzyme catalysis and biological signaling.

Potential Applications

Given its structural characteristics, N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline may find applications in:

  • Pharmaceutical Development: Researchers may explore its efficacy as a drug candidate, particularly in areas related to neurochemistry and antimicrobial agents.
  • Material Science: This compound could be considered for use in synthesizing novel materials due to its unique properties.

Conclusion

As a compound that blends the insights of organic chemistry with potential therapeutic applications, N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline stands as a testament to the complexity and beauty of chemical compounds. Its interactions within biological systems can inspire further research, showcasing the profound influence of chemistry on health and technology.

Synonyms
antazoline
91-75-8
Phenazoline
Antasten
Antistin
Antastan
Antihistal
Antistine
Histostab
Imidamine
Phenazolin
Antazolin
Antazolina
Azalone
Ben-A-hist
Antazolinum
Imidamin
N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
Antazolinum [Latin]
Antazolina [Spanish]
2-(N-Phenyl-N-benzylaminomethyl)imidazoline
Antazoline [INN:BAN]
Antazolinum [INN-Latin]
Antazolina [INN-Spanish]
Atazoline
N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline
2-(N-Benzylanilinomethyl)-2-imidazoline
Vasocon-A
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-
2-Phenyl-benzyl-amino-methylimidazolin
Antazoline (INN)
4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine
5512-M
HSDB 6506
Allergan A
EINECS 202-094-0
UNII-DHA8014SS1
2-Phenyl-benzyl-amino-methylimidazolin [German]
BRN 0233924
DHA8014SS1
CHEBI:84115
ANTAZOLINE [MI]
ANTAZOLINE [INN]
ANTAZOLINE [HSDB]
ANTAZOLINE [VANDF]
ANTAZOLINE [MART.]
ANTAZOLINE [WHO-DD]
91-75-8 (free base)
2-[(N-Benzylanilino)methyl]-2-imidazoline
Analergine
DTXSID3022613
2-Imidazoline, 2-((N-benzylanilino)methyl)-
2-Imidazoline, 2-[(N-benzylanilino)methyl]-
5-25-09-00364 (Beilstein Handbook Reference)
Antazolinum (Latin)
Antazolina (Spanish)
N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
Antazolinum (INN-Latin)
Antazolina (INN-Spanish)
ANTAZOLINE (MART.)
2-((N-BENZYLANILINO)METHYL)-2-IMIDAZOLINE
Benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine . HCl
2-Imidazoline, 2-(N-benzylanilinomethyl)-
NCGC00016613-01
CAS-2508-72-7
N-Benzyl-N-[(4,5-dihydro-1H-imidazol-2-yl)methyl]aniline
Antaz sulf
Antazoline (Standard)
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride
Spectrum_000789
Tocris-0791
Prestwick0_000258
Prestwick1_000258
Prestwick2_000258
Prestwick3_000258
Spectrum2_001259
Spectrum3_000303
Spectrum4_000141
Spectrum5_000818
SCHEMBL9437
CHEMBL1305
BSPBio_000076
BSPBio_001866
KBioGR_000582
KBioSS_001269
cid_17275
DivK1c_000083
SPBio_001198
SPBio_002295
BPBio1_000084
DTXCID902613
GTPL7116
HY-B1067AR
BDBM76862
HY-B1067A
KBio1_000083
KBio2_001269
KBio2_003837
KBio2_006405
KBio3_001366
R01AC04
R06AX05
NINDS_000083
HMS3604F14
4,5-dihydro-n-phenyl-n-(phenylmethyl)-1h-imidazole-2-methanamine
ALBB-023210
s5946
AKOS015911230
CCG-213074
DB08799
FA30098
IDI1_000083
NCGC00016613-02
NCGC00016613-03
NCGC00016613-04
NCGC00016613-05
NCGC00016613-06
NCGC00016613-07
NCGC00016613-18
NCGC00023164-03
LS-14580
SBI-0051285.P003
DB-050313
CS-0013323
NS00008002
2-(N-phenyl-N-benzylaminomethyl) imidazoline
D07458
G77641
AB00053420_19
AB00053420_20
EN300-6733612
L000841
Q771975
BRD-K99300445-001-01-2
BRD-K99300445-003-03-4
BRD-K99300445-003-20-8
BRD-K99300445-003-21-6
BRD-K99300445-011-02-9
BRD-K99300445-011-12-8
benzyl-(2-imidazolin-2-ylmethyl)-phenyl-amine;hydrochloride
N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline #
benzyl-(2-imidazolin-2-ylmethyl)-phenyl-amine;phosphoric acid
benzyl(4,5-dihydro-1H-imidazol-2-ylmethyl)phenylamine hydrochloride
Benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine HCl
N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline;hydrochloride
202-094-0