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Tizanidine Hydrochloride

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Identification
Molecular formula
C9H9Cl2N5
CAS number
64461-82-1
IUPAC name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride
State
State

Tizanidine hydrochloride is typically in solid state under standard conditions of temperature and pressure.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
356.00
Boiling point (Kelvin)
629.15
General information
Molecular weight
290.16g/mol
Molar mass
290.1640g/mol
Density
1.3200g/cm3
Appearence

Tizanidine hydrochloride appears as a white to off-white crystalline powder. It is odorless and has a bitter taste. The compound is often used in medical formulations.

Comment on solubility

Solubility of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride

The solubility of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride can vary significantly depending on several factors:

  • Polarity: The compound features both hydrophilic (amine and imidazole groups) and hydrophobic (benzyl and aromatic components) characteristics, which may influence its solubility in different solvents.
  • pH Dependency: Being a hydrochloride salt, this compound is generally more soluble in acidic conditions. An increase in hydrogen ion concentration can lead to improved solubilization.
  • Solvent Preference: The compound is expected to be more soluble in polar solvents such as water or methanol, particularly due to the presence of the quaternary amine. Conversely, it may exhibit lower solubility in non-polar solvents like hexane.

Furthermore, it is crucial to consider the potential for hydrogen bonding and structural interactions with the solvent, which can greatly facilitate or hinder solubility. Overall, determining the solubility profile of this compound in various solvents can lead to valuable insights for practical applications.

Interesting facts

Interesting Facts about N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; hydrochloride

This compound is a fascinating member of the class of organic compounds known for their medicinal properties. Here are some intriguing points about N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; hydrochloride:

  • Pharmacological Potential: This compound has been studied for its possible applications in pharmacology, particularly as potential therapeutic agents for various diseases. Its structure suggests it may interact with biological systems in unique ways.
  • Synthesis Challenges: The synthesis of this compound often involves complex multi-step reactions that require careful manipulation of reaction conditions to ensure the desired purity and yield, making it a remarkable example of modern synthetic organic chemistry.
  • Structure Versatility: The imidazole ring within the structure is a versatile motif found in many biologically active molecules, including key pharmaceuticals and natural products. This underscores the compound's potential role as a scaffold for drug development.
  • Analytical Techniques: Characterizing this compound often employs advanced analytical techniques such as NMR (Nuclear Magnetic Resonance) spectroscopy and mass spectrometry, which reveal insights into its molecular structure and confirm the integrity of the compound.
  • Research Significance: With ongoing research into related compounds, this specific hydrochloride variant serves as an important tool for understanding the relationships between structure, activity, and biological relevance, which is crucial in the field of medicinal chemistry.

In summary, N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; hydrochloride not only serves as an interesting study subject for chemists but also as a potential candidate for future drug discovery efforts, showcasing the remarkable intersection of chemistry and medicine.

Synonyms
Antazoline hydrochloride
Fenazolina
Antazolinium chloratum
UNII-FP8Q8F72JH
EINECS 219-719-8
FP8Q8F72JH
Phenazolinum (TN)
Antazoline hydrochloride [USP]
DTXSID1047782
2-Phenylbenzylaminomethylimidazoline hydrochloride
2-(N-Benzylanilino)methyl-2-imidazoline, hydrochloride
DTXCID1027762
ANTAZOLINE HYDROCHLORIDE [MI]
ANTAZOLINE HYDROCHLORIDE [MART.]
ANTAZOLINE HYDROCHLORIDE [VANDF]
ANTAZOLINE HYDROCHLORIDE [WHO-DD]
2-IMIDAZOLINE, 2-((N-BENZYLANILINO)METHYL)-, HYDROCHLORIDE
ANTAZOLINE HYDROCHLORIDE [EP MONOGRAPH]
Antazoline hydrochloride (USP)
ANTAZOLINE HYDROCHLORIDE (MART.)
ANTAZOLINE HYDROCHLORIDE (EP MONOGRAPH)
Phenazolinum
Antaz hcl
Hydrochloride, Antazoline
R.b.c.
219-719-8
2508-72-7
Antazoline HCl
Antazoline (hydrochloride)
2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride
MFCD00058145
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline hydrochloride
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, hydrochloride (1:1)
MLS000028599
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride
N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride
Histazine
SMR000058731
2508-72-7 (HCl)
N-benzyl-N-[(4,5-dihydro-1H-imidazol-2-yl)methyl]aniline hydrochloride
Antistine hydrochloride
Phenazoline hydrochloride
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride
SR-01000000255
NCGC00016613-01
CAS-2508-72-7
Prestwick_82
2-(N-Phenyl-N-benzylaminomethyl)imidazoline hydrochloride
2-Imidazoline, 2-((N-benzylanilino)methyl)-, monohydrochloride
Opera_ID_1387
MLS001148371
MLS002153486
MLS002222161
REGID_for_CID_17275
CHEMBL1256819
HY-B1067R
SWKDMSRRIBZZAY-UHFFFAOYSA-N
benzyl-(4,5-dihydro-1h-imidazol-2-ylmethyl)-phenyl-amine hcl
HMS1568D18
BCP32138
HY-B1067
Tox21_110524
s4199
AKOS015916586
Antazoline (hydrochloride) (Standard)
Tox21_110524_1
1ST158964A
AC-8174
CCG-220258
CS-4623
Antazoline HCl;Phenazoline hydrochloride
NCGC00016613-10
NCGC00180986-01
AS-74198
A2132
NS00082036
SW196394-3
D07459
H11312
EN300-6731077
SR-01000000255-3
SR-01000000255-6
Q27278115
Z2756516821
Antazoline Hydrochloride 1.0 mg/ml in Methanol (as free base)
Antazoline hydrochloride, European Pharmacopoeia (EP) Reference Standard
N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)anilinehydrochloride