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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
N'-benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine
State
State

At room temperature, diphenhydramine is typically in a solid state. It is commonly encountered as a part of pharmaceutical compositions in tablet or capsule form, particularly its hydrochloride variant.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
164.00
Boiling point (Kelvin)
437.15
General information
Molecular weight
255.36g/mol
Molar mass
255.3570g/mol
Density
1.0279g/cm3
Appearence

Diphenhydramine is typically a white, crystalline substance. It may also appear as a white powder, often utilized in its hydrochloride salt form for medical and pharmaceutical applications.

Comment on solubility

Solubility of N'-benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine

N'-benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine, a complex organic compound, exhibits interesting solubility characteristics due to its specific molecular structure. Being amine-based, it often demonstrates variable solubility in different solvents:

  • Solubility in polar solvents: This compound tends to be more soluble in polar solvents such as water and alcohols. The presence of both aromatic and aliphatic components allows it to engage in hydrogen bonding with water molecules, enhancing its solubility.
  • Solubility in non-polar solvents: Conversely, it may show limited solubility in non-polar solvents such as hexane or benzene. The presence of large hydrophobic benzyl and phenyl groups might hinder its dissolvability in such mediums.
  • Temperature dependency: Like many organic compounds, the solubility can also change with temperature. As temperature increases, the solubility may improve due to increased molecular activity.
  • pH influence: The solubility of this compound may also be affected by the pH of the solution, particularly given the presence of amine functionalities that can undergo protonation, altering the compound’s interactions with the solvent.

In summary, the solubility of N'-benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine is influenced by a blend of its molecular characteristics and the nature of the solvent. Understanding these solubility patterns is crucial for applications in chemical processes and formulations.

Interesting facts

Interesting Facts about N'-Benzyl-N,N-Dimethyl-N'-Phenyl-Ethane-1,2-Diamine

N'-Benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine is a fascinating compound that finds applications in both academic research and industrial processes. Here are some intriguing insights into this compound:

  • Pharmaceutical Relevance: This compound is frequently investigated for its potential use in pharmacology, particularly as a building block for synthesizing various pharmaceutical agents.
  • Structural Characteristics: The presence of multiple amine groups allows for diverse interactions with other molecules, making it an interesting subject for studies on chemical reactivity and bonding.
  • Functional Versatility: Its structure supports modifications that can enhance its properties, leading to derivatives with tailored functionalities useful in different chemical applications.
  • Mechanistic Studies: Scientists utilize this compound to examine reaction mechanisms, especially in studies related to nucleophilic substitutions and the role of amines in complex chemical systems.

As chemistry students delve into the study of this compound, they often discover that:

  • Such compounds can serve as excellent case studies for learning about chirality and stereochemistry.
  • They are also vital in exploring thermodynamic properties and kinetic behavior in organic reactions.

In conclusion, N'-benzyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine is not just a chemical formula, but a gateway to understanding intricate chemical relationships and advancing industrial applications. The study of this compound can lead to breakthroughs in various fields, illustrating the ever-evolving nature of chemical science.

Synonyms
PHENBENZAMINE
Antergan
Lergitin
961-71-7
Dimetina
Bridal
N-Benzyl-N',N'-dimethyl-N-phenylethylenediamine
NCI-C60719
PM245
PM 245
UNII-733W48NG2Q
2339 RP
RP 2339
BRN 2738634
Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-
733W48NG2Q
PHENBENZAMINE [WHO-DD]
DTXSID3043863
1,2-Ethanediamine, N,N-dimethyl-N'-phenyl-N'-(phenylmethyl)-
4-12-00-02324 (Beilstein Handbook Reference)
PM-245
1,2-ETHANEDIAMINE, N1,N1-DIMETHYL-N2-PHENYL-N2-(PHENYLMETHYL)-
N,N-DIMETHYL-N'-PHENYL-N'-PHENYLMETHYL-1,2-ETHANEDIAMINE
DTXCID1023863
2339 RB
N-(2-DIMETHYLAMINOETHYL)-N-BENZYLANILINE
N-BENZYL-N',N-DIMETHYL-N-PHENYLETHYLENEDIAMINE
N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine
SCHEMBL94485
CHEMBL157118
CHEBI:135041
benzyl-(2-dimethylaminoethyl)-phenyl-amine
Q18388093