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Hexamethylphosphoramide

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Identification
Molecular formula
C6H18N3O4P
CAS number
680-31-9
IUPAC name
N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine
State
State

At room temperature, hexamethylphosphoramide is in a liquid state. Its stability and consistency allow it to be easily handled under standard laboratory conditions.

Melting point (Celsius)
7.20
Melting point (Kelvin)
280.35
Boiling point (Celsius)
235.50
Boiling point (Kelvin)
508.65
General information
Molecular weight
179.21g/mol
Molar mass
179.2090g/mol
Density
1.0275g/cm3
Appearence

Hexamethylphosphoramide is a colorless liquid with a distinctive amine-like odor. It is often used in laboratories and industrial settings. Caution is advised as it can absorb water upon exposure to air, causing it to form a water-containing layer on its surface.

Comment on solubility

Solubility of N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine (C6H18N3O4P)

The solubility of N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine is an intriguing subject stemming from its unique chemical structure. This compound contains both phosphonate and amine groups, which can significantly influence its interaction with solvent systems.

Factors Affecting Solubility

Several factors may contribute to the solubility behavior of this compound:

  • Polar vs. Non-Polar Solvents: Given its polar nature due to the phosphonic groups, it is expected to have higher solubility in polar solvents, such as water or alcohols.
  • Hydrogen Bonding: The presence of multiple amine groups can facilitate hydrogen bonding, potentially enhancing solubility in water.
  • Concentration Effects: At different concentrations, the solubility can change, particularly if the compound forms aggregates or complexes in solution.

General Observations

While specific solubility data might not always be easy to find, it is reasonable to assume:

  • The compound may be moderately soluble in polar solvents.
  • It could be sparingly soluble in non-polar solvents due to its polar functional groups.

In summary, the solubility of N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine is influenced by its functional groups and requires careful consideration of the solvent's polarity to predict its behavior effectively.

Interesting facts

Interesting Facts about N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine

N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine is a fascinating compound, primarily due to its intricate structure and potential applications in medicinal chemistry and biochemistry.

1. Structure and Functionality

This compound showcases a complex architecture characterized by the presence of two isopropylamino groups, which contribute to its basic properties. The phosphorylation part of the molecule plays a critical role in biochemical processes, particularly in signal transduction and cellular communication.

2. Potential Applications

  • Drug Development: With its phosphoryloxy groups, this compound could be an important candidate in drug development, especially in therapeutics targeting neurological disorders.
  • Catalysis: The unique chemical groups in the structure may enhance catalytic activities, making it interesting for further research in synthesizing various organic compounds.

3. Biological Importance

Phosphorylation is a key mechanism in biological systems; therefore, compounds like this one serve as vital tools for scientists investigating metabolic pathways. As quoted from a well-known biochemist, "Understanding phosphorylation is akin to unlocking the language of life."

4. Synthesis Considerations

The synthesis of such a compound presents several challenges, particularly in ensuring the correct configuration of the isopropylamino groups. Researchers often utilize protecting groups during the synthetic process to avoid unwanted reactions.

5. Interdisciplinary Interests

This compound straddles multiple fields:

  • Chemistry: Synthetic and analytical methods
  • Biology: Enzyme activity and regulation
  • Pharmacology: Drug interactions and efficacy

In summary, N-[bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine not only exemplifies the intricacies of modern organic synthesis but also highlights the interconnected nature of chemistry and biological sciences.

Synonyms
iso-OMPA
tetraisopropyl pyrophosphoramide
513-00-8
Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)-
TETRAISOPROPYLPYROPHOSPHAMIDE
Tetraisopropylpyrophosphoramide
Tetra(monoisopropyl)pyrophosphortetramide
N,N',N'',N'''-Tetraisopropyldiphosphoramide
N-[bis(propan-2-ylamino)phosphoryloxy-(propan-2-ylamino)phosphoryl]propan-2-amine
EINECS 208-149-5
MLS002153308
CHEMBL494887
DTXSID00965589
Iso OMPA
Lopac-T-1505
Lopac0_001184
Tetraisoproryl Pyrophosphoramide
SCHEMBL6263949
Tetraisopropyl pyrophos-phoramide
BDBM10625
IOIMDJXKIMCMIG-UHFFFAOYSA-
CHEBI:182475
DTXCID101393255
HMS2236P05
HMS3263N09
HMS3372B16
Tox21_501184
AKOS016015535
N-[Bis(isopropylamino)phosphoryloxy-(isopropylamino)phosphoryl]propan-2-amine
CCG-205258
LP01184
SDCCGSBI-0051151.P002
NCGC00016002-01
NCGC00016002-02
NCGC00016002-03
NCGC00016002-04
NCGC00016002-05
NCGC00016002-06
NCGC00094438-01
NCGC00094438-02
NCGC00261869-01
SMR001230724
DB-051938
HY-131922
CS-0143402
EU-0101184
NS00043577
N,N',N'',N -tetra-iso-Propylpyrophosphoramide
T 1505
SR-01000076147
SR-01000076147-1
Pyrophosphorotetramide, N,N',N'',N'''-tetra(isopropyl)-
Tetraisopropyl pyrophosphoramide, butyrylcholinesterase inhibitor
({[bis(propan-2-ylamino)phosphoryl]oxy}(propan-2-ylamino)phosphoryl)(propan-2-yl)amine
N-[bis(propan-2-ylamino)phosphoryloxy-(propan-2-ylamino)phosphoryl]propan-2-amin
208-149-5
InChI=1/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)