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Acebutolol

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Identification
Molecular formula
C18H28N2O4
CAS number
37517-30-9
IUPAC name
N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide
State
State

At room temperature, acebutolol is in a solid state.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
254.00
Boiling point (Kelvin)
527.15
General information
Molecular weight
336.43g/mol
Molar mass
336.4340g/mol
Density
1.2000g/cm3
Appearence

Acebutolol typically appears as a white or off-white crystalline powder.

Comment on solubility

Solubility of N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide

The solubility of N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide can vary significantly based on several factors, including temperature, pH, and the presence of other solutes. This compound features a complex structure that can affect its interaction with solvents.

Key Factors Influencing Solubility:

  • Polarity: The presence of both hydrophobic (butyl group) and hydrophilic (hydroxyl and amine groups) sections in the molecule suggests that mixed polarity behavior may arise, promoting solubility in both organic solvents and water under certain conditions.
  • Temperature: Increased temperatures typically enhance the solubility of solids in liquids, which can lead to greater dissolution of this compound in warmer solvents.
  • pH Levels: Since the compound contains an amine, its solubility could be increased in acidic conditions due to protonation, leading to more soluble ionic species.
  • Solvent Choice: This compound might exhibit better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to water.

In essence, understanding the solubility characteristics of N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide requires consideration of its molecular structure and the environmental conditions, often underscoring the importance of contextual factors in chemistry.

Interesting facts

Interesting Facts About N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide

N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide is a fascinating compound, primarily studied for its potential therapeutic applications. Here are some notable aspects of this unique chemical:

  • Pharmaceutical Relevance: This compound is often investigated for its role as a drug candidate, specifically in the area of treating conditions related to the central nervous system.
  • Structure-Activity Relationship: The distinct structure of the compound—with the inclusion of a butyl group and an isopropylamino moiety—offers a rich platform for exploring how variations in molecular structure can influence biological activity.
  • Hydrogen Bonding: The hydroxyl group present in the compound can participate in hydrogen bonding, enhancing its interactions with biological macromolecules and potentially improving its efficacy as a pharmacological agent.
  • In Silico Studies: Computational chemistry techniques are often employed to predict the behavior of this compound in biological systems, providing insights into its absorption, distribution, metabolism, and excretion (ADME) properties.
  • Potential Applications: Beyond its central nervous system applications, research is ongoing into other therapeutic uses, underscoring its versatility in medicinal chemistry.

As a compound of interest in the field of pharmacology, N-butyl-4-[2-hydroxy-3-(isopropylamino)propoxy]benzamide highlights the intricate relationship between molecular structure and biological function. Scientists continue to explore its potential, revealing new dimensions of its utility in medicinal development.

Synonyms
BRN 2141203
27519-62-6
N-Butyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzamide
BENZAMIDE, N-BUTYL-4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-
RefChem:322478
DTXSID00950197
N-Butyl-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzamide