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Daprodustat

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Identification
Molecular formula
C19H27N3O4
CAS number
960539-70-2
IUPAC name
N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide
State
State

At room temperature, Daprodustat is in a solid state, specifically as a crystalline solid form. It is stable under normal conditions used in laboratory handling. The compound should be handled with standard laboratory procedures for solids.

Melting point (Celsius)
188.00
Melting point (Kelvin)
461.15
Boiling point (Celsius)
482.50
Boiling point (Kelvin)
755.70
General information
Molecular weight
397.54g/mol
Molar mass
398.5170g/mol
Density
1.3271g/cm3
Appearence

Daprodustat appears as a crystalline solid with a color that ranges from white to white with an off-white hue. Its crystal form and purity may impact this appearance slightly.

Comment on solubility

Solubility of N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide

The solubility of N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide can be influenced by several factors, given its complex structure. Understanding its solubility is crucial for applications in pharmaceuticals and material science.

Key Factors Affecting Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups increases polarity, potentially enhancing solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water may also affect its solubility, suggesting that N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide may be more soluble in aqueous solutions.
  • Temperature: Like many organic compounds, solubility may increase with temperature.

In general, compounds similar to N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide often exhibit:

  • Moderate solubility in water due to the combined effects of hydrophobic cyclohexyl groups and polar functional groups.
  • Better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).

To summarize, while N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide exemplifies characteristics that may lead to moderate solubility across various solvents, experimental data is essential for precise quantification of its solubility in specific applications. Exploring its solubility can unveil new possibilities in drug formulation and development.

Interesting facts

Interesting Facts about N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide

N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide is a fascinating compound with potential applications in the field of medicinal chemistry. Here are some intriguing aspects to consider:

1. Structural Complexity

This compound features a unique structural arrangement that includes:

  • A cyclohexyl group, which contributes to its lipophilicity.
  • A hydroxyl group that can enhance its solubility in polar environments.
  • A benzamide core that is frequently found in various bioactive molecules.

2. Biological Significance

The presence of amino groups in its structure suggests that this compound may interact with biological systems, potentially making it interesting for:

  • Drug design and development.
  • Research related to enzyme inhibition.
  • Treatment of various diseases, particularly in the realm of cancer therapy.

3. Synthetic Potential

The synthesis of this compound raises several questions and opportunities for chemists:

  • What synthetic methods can be employed to efficiently produce this compound?
  • Can modifications to its structure enhance its pharmacological properties?
  • The use of green chemistry techniques for its synthesis.

4. Future Directions

Research opportunities abound for N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide:

  • Investigating its mechanism of action at the molecular level.
  • Studying its interactions with specific biological targets.
  • Exploring its potential in combination therapies to overcome drug resistance.

In summary, N-cyclohexyl-4-[[2-(cyclohexylamino)acetyl]amino]-2-hydroxy-benzamide is more than just a chemical entity; it represents a potential key player in the ongoing exploration of new therapeutic agents. As researchers continue to unravel its properties, it may pave the way for innovative solutions in pharmaceuticals.