Skip to main content

Ibuprofen

ADVERTISEMENT
Identification
Molecular formula
C13H18O2
CAS number
15687-27-1
IUPAC name
N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide
State
State

At room temperature, ibuprofen is in the solid state.

Melting point (Celsius)
76.00
Melting point (Kelvin)
349.15
Boiling point (Celsius)
157.00
Boiling point (Kelvin)
430.15
General information
Molecular weight
206.28g/mol
Molar mass
206.2840g/mol
Density
1.0300g/cm3
Appearence

Ibuprofen typically appears as a white crystalline powder, which may have a slight characteristic odor. It is often marketed in tablet or liquid form for medical use. It is poorly soluble in water but dissolves in organic solvents such as methanol and acetone.

Comment on solubility

Solubility of N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide

The solubility of N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide can be analyzed based on its molecular structure and the presence of functional groups.

  • Polarity: The alcohol group (-OH) present in the benzamide structure often increases solubility in polar solvents, such as water.
  • Hydrophobic Regions: The isopropyl and ethyl groups contribute to the hydrophobic characteristics, potentially limiting solubility in highly polar solvents.
  • Overall Behavior: Its solubility may vary significantly in different solvents, making it more soluble in organic solvents like ethanol or methanol compared to water.

In summary, N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide exhibits a complex solubility profile influenced by both hydrophilic and hydrophobic interactions. Thus, for practical applications, it is recommended to conduct solubility tests in specific solvents to ascertain its behavior under varied conditions.

Interesting facts

Interesting Facts about N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide

N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide is a fascinating compound within the realm of organic chemistry, particularly due to its unique structure and potential applications. Here are some key highlights:

  • Functional Diversity: This compound contains multiple functional groups, including an amide and a hydroxyl group, which contribute to its chemical reactivity and interactions with other substances.
  • Pharmaceutical Relevance: The structure suggests that it may have pharmaceutical applications, particularly as a potential candidate in drug discovery due to its ability to influence biological systems.
  • Substituent Effects: The positioning of substituents (like the ethyl, isopropyl, and methyl groups) on the benzene ring plays a crucial role in determining the compound's properties, including solubility and biological activity.
  • Synthetic Pathways: Chemists can synthesize this compound via several synthetic routes, showcasing the versatility in organic synthesis techniques. These methods often involve coupling reactions and the introduction of substituents through electrophilic aromatic substitution.
  • Structure-Activity Relationship (SAR): Understanding how variations in its structure affect its activity can lead to the development of more effective derivatives tailored for specific biological targets.

In summary, N-ethyl-2-hydroxy-3-isopropyl-6-methyl-benzamide exemplifies the complexity and potential utility of organic compounds. Its intriguing structure opens up avenues for research and experimentation in various chemical and pharmaceutical domains.

Synonyms
N-Ethyl-3-isopropyl-6-methylsalicylamide
BRN 2581150
3893-88-7
p-CYMENE-2-CARBOXAMIDE, N-ETHYL-3-HYDROXY-
Salicylamide, N-ethyl-3-isopropyl-6-methyl-
DTXSID80192215
DTXCID90114706