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N-ethyl-o-toluenesulfonamide

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Identification
Molecular formula
C9H13NO2S
CAS number
80-39-7
IUPAC name
N-ethyl-2-methyl-benzenesulfonamide
State
State

At room temperature, N-ethyl-o-toluenesulfonamide is typically in a solid state. Its crystalline structure lends to its stability at standard conditions.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
213.29g/mol
Molar mass
213.2940g/mol
Density
1.2100g/cm3
Appearence

N-ethyl-o-toluenesulfonamide typically appears as a colorless to light yellow solid or crystalline powder. Its appearance can vary depending on the purity of the sample. It is often odorless or has a faint characteristic smell.

Comment on solubility

Solubility of N-ethyl-2-methyl-benzenesulfonamide

N-ethyl-2-methyl-benzenesulfonamide, known for its unique structure, exhibits interesting solubility characteristics that can influence its applications in various fields.

In terms of solubility:

  • Polar Solvents: This compound is generally more soluble in polar solvents such as water and alcohols. The sulfonamide group contributes to its polar nature, enhancing its affinity for these solvents.
  • Non-Polar Solvents: Conversely, N-ethyl-2-methyl-benzenesulfonamide shows reduced solubility in non-polar solvents like hexane or benzene, due to the lack of strong intermolecular interactions.
  • Temperature Effects: The solubility is also influenced by temperature; higher temperatures may increase the solubility of this compound in polar solvents, facilitating its use in heat-sensitive applications.

To summarize, the solubility of N-ethyl-2-methyl-benzenesulfonamide can be encapsulated by the following key points:

  1. Good solubility in polar solvents
  2. Poor solubility in non-polar solvents
  3. Temperature sensitivity regarding solubility in polar environments

In conclusion, understanding the solubility profile of N-ethyl-2-methyl-benzenesulfonamide not only aids in predicting its behavior in various chemical processes but also informs its practical applications in pharmaceutical formulations and other industries.

Interesting facts

Interesting Facts about N-Ethyl-2-methyl-benzenesulfonamide

N-Ethyl-2-methyl-benzenesulfonamide is a fascinating compound with a variety of applications and properties that interest chemists and pharmacologists alike.

Applications and Uses

  • Pharmaceutical Industry: This compound serves as an important building block in the synthesis of various therapeutic agents.
  • Research Tool: Due to its sulfonamide structure, it is often utilized in experimental studies related to enzyme inhibition and the development of new drugs.
  • Agricultural Chemistry: It can also be found in agricultural formulations, demonstrating its versatility across different fields.

Chemical Behavior

As a sulfonamide, N-ethyl-2-methyl-benzenesulfonamide exhibits unique chemical behaviors that are crucial for its functionality:

  • Amino Group Interaction: The sulfonamide group can participate in hydrogen bonding, enhancing its solubility and reactivity.
  • Electrophilicity: The presence of the sulfonyl group makes the compound an excellent electrophile, enabling it to engage in various chemical reactions.

Historical Context

The discovery of sulfonamide compounds was groundbreaking in the early 20th century, leading to significant advancements in antimicrobial therapy. The development of sulfa drugs paved the way for modern antibiotics, transforming the treatment of bacterial infections.

Quote from Notable Chemist

As the renowned chemist Paul Ehrlich stated, "The right chemical can change the course of medicine." N-ethyl-2-methyl-benzenesulfonamide exemplifies this principle by contributing to several key developments in the pharmaceutical sector.

In conclusion, N-ethyl-2-methyl-benzenesulfonamide is more than just a compound; it is a testament to the intricate relationship between chemistry and real-world applications, making it a subject of enduring interest for researchers and students alike.

Synonyms
N-ETHYL-O-TOLUENESULFONAMIDE
1077-56-1
N-Ethyl-2-methylbenzenesulfonamide
Benzenesulfonamide, N-ethyl-2-methyl-
N-Ethyltoluene-2-sulphonamide
o-Toluenesulfonamide, N-ethyl-
HSDB 5782
O-TOLUENE ETHYL SULFONAMIDE
UNII-6Y8J5WET03
Uniplex 108
6Y8J5WET03
EINECS 214-073-3
DTXSID5052416
N-ETHYL-O-TOLUENESULFONAMIDE [HSDB]
oToluenesulfonamide, Nethyl
DTXCID1030101
Benzenesulfonamide, Nethyl2methyl
8047-99-2
natwuqfqfmzvmt-uhfffaoysa-n
N-ethyl-2-methylbenzene-1-sulfonamide
n-e-o/ptsa
MFCD00059226
N-Ethyl-2-toluenesulfonamide
SCHEMBL126986
N-Ethyl-o(or p)-toluenesulfonamide
AKOS006275681
AS-59292
DB-221628
CS-0440504
NS00010733
D88149
EN300-1452505
Q27265713