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N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide

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Identification
Molecular formula
C17H20NO2
CAS number
125635-71-0
IUPAC name
N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide
State
State

At room temperature, N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide is typically in a solid state. It is often handled in powder or crystalline form, making it important to consider factors such as humidity and storage conditions to maintain its stability.

Melting point (Celsius)
142.80
Melting point (Kelvin)
415.80
Boiling point (Celsius)
390.60
Boiling point (Kelvin)
663.80
General information
Molecular weight
286.36g/mol
Molar mass
286.3570g/mol
Density
1.1452g/cm3
Appearence

N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide is typically a crystalline solid. Its appearance can vary from white to an off-white color, and it is usually available in powder form. The compound is stable under normal conditions and should be handled with proper care to prevent decomposition or reaction with incompatible substances.

Comment on solubility

Solubility of N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide

N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide, with the chemical formula C17H20NO2, exhibits notable solubility characteristics that are influenced by various factors. Understanding these characteristics can be essential for its application in different chemical contexts.

Solubility Considerations

The solubility of this compound can be impacted by several factors:

  • Polarity: The presence of functional groups such as the amide and hydroxyl groups contributes to the overall polarity of the molecule, which may enhance its solubility in polar solvents like water.
  • Solvent Type: Typically, compounds with similar polarity will dissolve well together. This compound may show good solubility in organic solvents like ethanol or methanol.
  • Temperature and pH: Changes in temperature and pH can significantly influence the solubility. For instance, the solubility may increase at higher temperatures or with adjustments to the pH levels of the solution.

In general, it is likely that N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide has moderate solubility in water but potentially high solubility in organic solvents due to the hydrophobic phenyl group counterbalancing the polar functional groups.

Understanding solubility is crucial for applications in drug formulation and chemical synthesis, as it can affect bioavailability and stability.

Interesting facts

Interesting Facts about N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide

N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide is a fascinating compound that belongs to the category of amides and exhibits intriguing properties which have garnered interest in various scientific fields!

Chemical Characteristics

  • Pharmacological Potential: This compound has drawn attention for its potential biological activity. Its structure may influence interactions with biological systems, making it a candidate for drug development.
  • Structural Diversity: The unique amalgamation of functional groups in N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide contributes to its chemical reactivity and solubility patterns, which can be leveraged in various applications.
  • Applications in Research: Researchers are exploring compounds like this one for their properties in medicinal chemistry, particularly in targeting neurological receptors or as anti-inflammatory agents.

Synthesis and Applications

The synthesis of this compound is a topic of interest due to its complexity; it offers an insight into advanced organic synthesis techniques, including:

  • Amide Bond Formation: The formation of amide bonds is a crucial step in pharmaceutical chemistry and materials science.
  • Substituent Influence: The varying substituents such as the ethyl group and phenyl ring affect the compound's overall reactivity and stability.

Why It Matters

In summary, N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide is not just a chemical compound but a cornerstone of exploration in:

  • Medicinal Chemistry: Potential therapeutic applications make it an exciting subject.
  • Organic Synthesis: The study of its synthesis aids in understanding essential chemical processes.
  • Material Science: Its properties might be harnessed to create innovative materials.

As we continue to deepen our understanding of such compounds, we delves into the interplay of chemistry and biology that underpins drug design and development! As one of the prominent chemists once said, "Chemistry is about the connections that relate the smallest particles to the grand scale of matter." This compound certainly exemplifies that connection!

Synonyms
tropicamide
1508-75-4
Mydriacyl
Bistropamide
Mydriaticum
Visumidriatic
Tropicacyl
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
Epitromina
Tropicamidum
Tropicamida
Tropikamid
Tropimil
Ro 1-7683
Tropicamid
N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
Tropicamidum [INN-Latin]
Tropicamida [INN-Spanish]
N-Ethyl-N-(4-pyridylmethyl)tropamid
N-Ethyl-N-(4-pyridylmethyl)tropamide
UNII-N0A3Z5XTC6
EINECS 216-140-2
N0A3Z5XTC6
NSC-757372
BRN 0285563
Mydriafair
DTXSID8045220
N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
Minims tropicamide
MFCD00058580
Mydrum
Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)-
RO-1-7683
DTXCID6025220
5-22-09-00359 (Beilstein Handbook Reference)
PAREMYD COMPONENT TROPICAMIDE
NSC 757372
Tropicamide [USAN:USP:INN:BAN:JAN]
NCGC00016065-07
Opticyl
Tropicamidum (INN-Latin)
Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)-
Tropicamida (INN-Spanish)
TROPICAMIDE (MART.)
TROPICAMIDE [MART.]
TROPICAMIDE (USP-RS)
TROPICAMIDE [USP-RS]
TROPICAMIDE (EP MONOGRAPH)
TROPICAMIDE [EP MONOGRAPH]
TROPICAMIDE (USP MONOGRAPH)
TROPICAMIDE [USP MONOGRAPH]
(+/-)-N-ETHYL-2-PHENYL-N-(4-PYRIDYLMETHYL)HYDRACRYLAMIDE
Tropicamide (USAN:USP:INN:BAN:JAN)
Mydriacyl (TN)
SMR000058523
SR-01000075351
l-Picamide
Tropicamide, solid
Prestwick_487
CAS-1508-75-4
component of Paremyd
(+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
Spectrum_000584
Tropicamide (Standard)
TROPICAMIDE [MI]
Prestwick0_000228
Prestwick1_000228
Prestwick2_000228
Prestwick3_000228
Spectrum2_000936
Spectrum3_000655
Spectrum4_000377
Spectrum5_001585
TROPICAMIDE [INN]
TROPICAMIDE [JAN]
TROPICAMIDE [USAN]
T 9778
TROPICAMIDE [VANDF]
Lopac0_001223
SCHEMBL23975
BSPBio_000275
BSPBio_002289
KBioGR_000873
KBioSS_001064
TROPICAMIDE [WHO-DD]
TROPICAMIDE [WHO-IP]
MLS001306442
MLS002154240
DivK1c_000448
SPECTRUM1500599
SPBio_000872
SPBio_002196
BPBio1_000303
CHEBI:9757
GTPL7319
Tropicamide (JP18/USP/INN)
CHEMBL1200604
BDBM82371
HMS501G10
HY-B0321R
KBio1_000448
KBio2_001064
KBio2_003632
KBio2_006200
KBio3_001509
S01FA06
TROPICAMIDE [ORANGE BOOK]
NINDS_000448
HMS1568N17
HMS1921I09
HMS2089M05
HMS2092A18
HMS2095N17
HMS2235J15
HMS3259M18
HMS3263F08
HMS3267A13
HMS3373B07
HMS3411F14
HMS3651K04
HMS3675F14
HMS3712N17
HMS3742C05
HMS3884E16
Pharmakon1600-01500599
Tropicamide for peak identification
BCP13504
HY-B0321
NSC_5593
TROPICAMIDUM [WHO-IP LATIN]
Tox21_110297
Tox21_501223
AC-816
BBL028074
CCG-40076
MYDCOMBI COMPONENT TROPICAMIDE
NSC757372
s1913
STK934612
AKOS005664076
Tox21_110297_1
DB00809
FT28615
KS-5174
LP01223
NC00589
SDCCGSBI-0051190.P004
TROPICAMIDE COMPONENT OF PAREMYD
Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)-
IDI1_000448
SMP1_000304
NCGC00016065-03
NCGC00016065-04
NCGC00016065-05
NCGC00016065-06
NCGC00016065-08
NCGC00016065-09
NCGC00016065-11
NCGC00016065-22
NCGC00024866-02
NCGC00024866-03
NCGC00024866-04
NCGC00024866-05
NCGC00024866-06
NCGC00261908-01
DA-78656
CAS_1508-75-4
SBI-0051190.P003
AB00052120
EU-0101223
NS00005569
SW196691-3
T1470
C72868
D00397
Q29310
AB00052120-10
AB00052120_11
AB00052120_12
EN300-7357022
L001262
N-Ethyl-2-phenyl-N-(4-pyridylmethyl hydracrylamide
SR-01000075351-1
SR-01000075351-3
SR-01000075351-5
SR-01000075351-7
BRD-A79672927-001-05-8
BRD-A79672927-001-10-8
BRD-A79672927-001-18-1
BRD-A79672927-001-19-9
BRD-A79672927-001-20-7
Tropicamide, European Pharmacopoeia (EP) Reference Standard
N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide #
N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
N-Ethyl-3-hydroxy-2-phenyl-N-[(pyridin-4-yl)methyl]propanamide
Tropicamide, United States Pharmacopeia (USP) Reference Standard
BENZENEACETAMIDE, N-ETHYL-.ALPHA.-(HYDROXYMETHYL)-N-(4-PYRIDINYLMETHYL)-, (+/-)-
Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard
216-140-2