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N-ethyl-4-methylbenzenesulfonamide

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Identification
Molecular formula
C9H13NO2S
CAS number
80-39-7
IUPAC name
N-ethyl-4-methyl-benzenesulfonamide
State
State

At room temperature, N-ethyl-4-methylbenzenesulfonamide is typically a solid. It is known to form crystalline structures and may appear as a fine powder.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.15
Boiling point (Celsius)
325.10
Boiling point (Kelvin)
598.25
General information
Molecular weight
199.27g/mol
Molar mass
199.2680g/mol
Density
1.1676g/cm3
Appearence
N-ethyl-4-methylbenzenesulfonamide is typically seen as a colorless to light yellow solid. It may come in a crystalline form and sometimes appears as a powder.
Comment on solubility

Solubility of N-ethyl-4-methyl-benzenesulfonamide

N-ethyl-4-methyl-benzenesulfonamide, with the chemical formula C10H13NO2S, exhibits interesting solubility characteristics that can be influenced by several factors. Here are key points to consider:

  • Polar vs. Non-polar Solvents: This compound is more soluble in polar solvents due to the presence of the sulfonamide group, which can engage in hydrogen bonding.
  • Temperature Dependence: It's important to note that its solubility may increase with rising temperatures, typical for many organic compounds.
  • pH Sensitivity: The solubility of sulfonamides can be influenced by the pH of the solution; acidic conditions can impact the ionization state of the compound.
  • Presence of Salts: The addition of certain salts may either enhance or reduce the solubility, depending on the ionic strength.

As a general observation, "like dissolves like," meaning that hydrophilic compounds will typically be more soluble in water or alcohols, while lipophilic compounds are favored in organic solvents. For N-ethyl-4-methyl-benzenesulfonamide, focusing on its interaction with solvents will provide insights into its practical applications and behavior in various environments.

Interesting facts

Interesting Facts about N-ethyl-4-methyl-benzenesulfonamide

N-ethyl-4-methyl-benzenesulfonamide is a fascinating compound with a variety of applications and intriguing properties. Here are some interesting insights:

Chemical Significance

  • Structural Insights: This compound features a sulfonamide functional group, which is known for its versatility in chemical reactions.
  • Applications: N-ethyl-4-methyl-benzenesulfonamide has been utilized in the synthesis of pharmaceuticals, contributing to advanced medicinal chemistry.
  • Biological Role: Some sulfonamides are recognized for their antibacterial properties, paving the way for the development of antibiotic medications.

Noteworthy Properties

  • Reactivity: Sulfonamide compounds, including this one, can participate in various reactions thanks to their diverse functional groups.
  • Synthesis Methods: The synthesis of N-ethyl-4-methyl-benzenesulfonamide often involves straightforward reactions that showcase the elegance of organic chemistry.

Trivia

  • Historical Context: The sulfonamide class of drugs was one of the first antibiotics discovered, marking a significant breakthrough in medical science.
  • Environmental Impact: Research into the environmental fate of sulfonamides is ongoing, as some compounds can exhibit persistence in ecological systems.
  • Structure-Activity Relationship: Understanding how modifications to its structure can affect biological activity makes it a compound of interest in drug design.

Overall, N-ethyl-4-methyl-benzenesulfonamide exemplifies the connections between chemistry and real-world applications, making it a compound worthy of further exploration!

Synonyms
N-ETHYL-P-TOLUENESULFONAMIDE
80-39-7
N-Ethyl-4-methylbenzenesulfonamide
N-Ethyl-p-tolylsulfonamide
Santicizer 3
Benzenesulfonamide, N-ethyl-4-methyl-
Ethyl tosylamide
N-Ethyl-4-toluenesulfonamide
N-Tosylethylamine
p-Tolueneethylsulfonamide
p-Toluenesulfonamide, N-ethyl-
1321-54-6
p-Toluenesulfonyl-N-ethylamide
ethyl-p-toluenesulfonamide
N-Ethyl-p-methylbenzenesulfonamide
N-Ethyltoluene-4-sulphonamide
N-Ethyl-4-methyl benzenesulfonamide
NSC 68803
CCRIS 6037
N-PTSA
EINECS 201-275-1
N-ethyl-4-methylbenzene-1-sulfonamide
DTXSID5025310
992S798SJB
NSC-68803
n-ethyl-p-toluene sulfonamide
DTXCID405310
4-Toluenesulfonamide, N-ethyl-
ETHYL P-TOLUENESULFONAMIDE
OHPZPBNDOVQJMH-UHFFFAOYSA-
N-?Ethyl-?p-?toluenesulfonamide
NTosylethylamine
UNII-992S798SJB
N-Ethyl-4-methyl-benzenesulfonamide
MFCD00048511
NEthylptolylsulfonamide
Unipex 108
pTolueneethylsulfonamide
Ethyl toluenesulfonamide
pTolueneNethylsulfonamide
pToluene ethylsulfonamide
NEthyl4toluenesulfonamide
NEthyltoluene4sulphonamide
p-toluene ethylsulfonamide
Ethyl tosylamide [INCI]
N-ethyl toluenesulfonamide
pToluenesulfonylNethylamide
n-ethyl-p-toluensulfonamid
pToluenesulfonamide, Nethyl
4Toluenesulfonamide, Nethyl
NCIOpen2_000527
NEthylpmethylbenzenesulfonamide
N-ethyl-4-toluene sulfonamide
NEthyl4methylbenzenesulfonamide
SCHEMBL126985
NEthyl4methyl benzenesulfonamide
NEthyl4methylbenzene sulfonamide
X3491OQT7S
CHEMBL1492809
Benzenesulfonamide, Nethyl4methyl
HMS1661F02
pToluenesulfonamide, Nethyl (8CI)
N-Ethyl-p-toluenesulfonamide, 98%
NSC68803
P-TOLUENE-N-ETHYLSULFONAMIDE
Tox21_200366
STK416319
N-ETHYL P-TOLUENE SULPHONAMIDE
N-ethyl(4-methyl phenyl) sulfonamide
P-TOLUNESULFONAMIDE, N-ETHYL-
AKOS000431178
CAS-80-39-7
NCGC00091206-01
NCGC00091206-02
NCGC00257920-01
AS-14234
N-ETHYL-4-METHYLBENZENE SULFONAMIDE
DB-056430
DB-371542
CS-0151957
E0674
NS00010912
EN300-15862
Q27272165
Z45528338
N-Ethyl-4-methylbenzenesulfonamide 100 microg/mL in Acetonitrile
1321-55-7
904-696-5