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Phenacetin

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Identification
Molecular formula
C10H13NO2
CAS number
62-44-2
IUPAC name
N-ethyl-N-(2-phenoxyethyl)acetamide
State
State

Phenacetin is a solid at room temperature, typically appearing in a crystalline form. It is insoluble in water but soluble in organic solvents such as ethanol and ether.

Melting point (Celsius)
134.50
Melting point (Kelvin)
407.65
Boiling point (Celsius)
323.00
Boiling point (Kelvin)
596.15
General information
Molecular weight
179.22g/mol
Molar mass
179.2160g/mol
Density
1.1064g/cm3
Appearence

Phenacetin appears as crystalline powder or flakes. It has a white or slightly pinkish hue. This compound is known for its distinct crystal structure and can form smooth, shiny surfaces when in crystalline form.

Comment on solubility

Solubility of N-ethyl-N-(2-phenoxyethyl)acetamide

N-ethyl-N-(2-phenoxyethyl)acetamide is a fascinating compound known for its unique solubility characteristics. Understanding its solubility is essential for its application in various chemical processes.

Solubility Characteristics

This compound exhibits the following solubility traits:

  • Solvent Affinity: N-ethyl-N-(2-phenoxyethyl)acetamide is generally soluble in alcohols and organic solvents such as acetone and ethyl acetate.
  • Water Solubility: Its solubility in water is limited, primarily due to the hydrophobic nature of the phenoxy group.
  • Temperature Dependence: Increased temperature can enhance its solubility in organic solvents, making it more effective in reactions at higher temperatures.

Factors Influencing Solubility

The solubility of N-ethyl-N-(2-phenoxyethyl)acetamide can be influenced by:

  • Functional Groups: The presence of both ethyl and phenoxy functional groups helps to mediate interactions with different solvents.
  • pH Levels: Changes in pH can affect the ionization state of the compound, subsequently influencing its solubility in aqueous environments.
  • Dielectric Constant: Solvents with varying dielectric constants can significantly impact the solvation dynamics of this compound.

Overall, the solubility of N-ethyl-N-(2-phenoxyethyl)acetamide showcases a complex interplay of molecular interactions and external conditions. It is crucial for chemists and researchers to consider these factors to effectively utilize this compound in diverse applications.

Interesting facts

Interesting Facts about N-ethyl-N-(2-phenoxyethyl)acetamide

N-ethyl-N-(2-phenoxyethyl)acetamide is a fascinating compound belonging to the class of acetamides, which are organic compounds commonly used in various applications. Here are some noteworthy aspects of this compound:

  • Pharmaceutical Potential: This compound has garnered attention in the field of medicinal chemistry. Its unique structure makes it a candidate for research in drug development, particularly for its potential effects on the central nervous system.
  • Chemical Structure: Featuring both an ethyl group and a phenoxyethyl moiety, its configuration allows for intriguing interactions at the molecular level, which can influence its biological activity.
  • Role of Phenoxy Group: The phenoxy group in the structure is known for enhancing lipophilicity, which could improve cell membrane penetration. This property is crucial when considering drug delivery.
  • Research Areas: Scientists are particularly interested in exploring structure-activity relationships (SAR) within compounds like N-ethyl-N-(2-phenoxyethyl)acetamide to understand how modifications to the structure can impact biological efficacy.
  • Synthetic Pathways: The synthesis of this compound can involve various organic reactions, showcasing the versatility of synthetic organic chemistry. Understanding these pathways is essential for efficient production.

In conclusion, N-ethyl-N-(2-phenoxyethyl)acetamide represents the intersection of organic synthesis and pharmacology, and its ongoing research could pave the way for novel therapeutic agents. The compound exemplifies how subtle changes in molecular structure can lead to significant variations in biological activity.

Synonyms
N-Ethyl-N-(2-phenoxyethyl)acetamide
ACETAMIDE, N-ETHYL-N-(2-PHENOXYETHYL)-
7465-20-5
NSC 400174
LA9U857LY1
N-Ethyl-N-(2-phenoxyethyl)-acetamide
NSC-400174
UNII-LA9U857LY1
DTXSID50225625
DTXCID80148116
NSC400174
DS-012054