Skip to main content

Etodolac

ADVERTISEMENT
Identification
Molecular formula
C17H21N3O3
CAS number
41340-25-4
IUPAC name
N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine
State
State

Etodolac is a solid at room temperature, with a crystalline structure.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
395.60
Boiling point (Kelvin)
668.75
General information
Molecular weight
316.37g/mol
Molar mass
316.3550g/mol
Density
1.3660g/cm3
Appearence

Etodolac typically appears as a white or off-white crystalline solid. It is usually odorless.

Comment on solubility

Solubility of N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine

N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine exhibits interesting solubility characteristics that can be influenced by several factors. Here’s a breakdown of its solubility profile:

  • Polarity: The presence of an ethyl group and a nitro substituent suggests a degree of polarity, which may enhance solubility in polar solvents such as water or alcohol.
  • Solvent Interactions: This compound is likely to be more soluble in organic solvents like ethanol or methanol due to van der Waals forces and potential hydrogen bonding given the amine functional group.
  • pH Dependence: As an amine, it may protonate under acidic conditions, increasing solubility in acidic environments while decreasing it in neutral or alkaline conditions.
  • Temperature: Like many organic compounds, solubility can be temperature-dependent, with increased solubility at elevated temperatures.

In summary, while specific solubility values can vary greatly based on experimental conditions, it is anticipated that N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine is soluble in polar organic solvents and may show varying solubility in water depending on the pH and temperature.

Interesting facts

N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine

This multifaceted compound is a remarkable member of the class of nitrogen-containing organic compounds. Here are some captivating facts about N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine:

  • Pharmacological Potential: Due to its structural resemblance to various neurotransmitters, this compound has attracted interest for its potential applications in neuropharmacology and the development of novel therapeutic agents.
  • Indole Moiety: The presence of the indole structure is particularly noteworthy. Indole derivatives often exhibit a range of biological activities, including antibacterial, antifungal, and even anticancer properties.
  • Nitro Group's Influence: The nitro group on the indole ring may also contribute to the compound's reactivity, affecting its overall pharmacodynamics and interactions within biological systems.
  • Synthetic Challenges: Developing this compound can present considerable synthetic challenges, making it a point of interest for organic chemists. The precise placement of the ethyl and nitro groups is crucial for the desired biological activity.
  • Potential Research Applications: N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine could serve as a scaffold for the synthesis of more complex molecules, lending itself to medicinal chemistry research aimed at innovating drug design.

“Understanding the nuances of compounds like N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine not only deepens our knowledge of chemical interactions but also continuously opens new doors in medicine and biochemistry.”

This compound is a prime example of how intricate structures can lead to significant implications in scientific research and pharmacology.

Synonyms
1147-97-3
INDOLE, 3-((DIETHYLAMINO)METHYL)-5-NITRO-
N,N-Diethyl-5-nitro-1H-indole-3-methanamine
N-ethyl-N-[(5-nitro-1H-indol-3-yl)methyl]ethanamine
BRN 0486245
3-((Diethylamino)methyl)-5-nitroindole
DTXSID40150836