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Etodolac

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Identification
Molecular formula
C17H21NO2
CAS number
41340-25-4
IUPAC name
N-ethyl-N-(o-tolyl)but-2-enamide
State
State

At room temperature, etodolac is a solid substance. It maintains its solid state under standard temperature and pressure conditions, making it suitable for formulation into tablets.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
173.00
Boiling point (Kelvin)
446.15
General information
Molecular weight
287.37g/mol
Molar mass
287.3690g/mol
Density
1.2375g/cm3
Appearence

Etodolac generally appears as a white or nearly white crystalline powder. The compound is relatively insoluble in water, which contributes to its powdery texture. When observed up close, the crystals might exhibit a subtle sheen due to their crystalline structure.

Comment on solubility

Solubility of N-ethyl-N-(o-tolyl)but-2-enamide (C17H21NO2)

N-ethyl-N-(o-tolyl)but-2-enamide, a compound with a complex structure, displays selective solubility characteristics that can be influenced by various factors. When evaluating its solubility, it is essential to consider the following:

  • Polarity: As an amide, the compound has polar functional groups, which generally enhances its solubility in polar solvents.
  • Hydrophobic Interactions: The presence of the ethyl and o-tolyl groups contributes to hydrophobic interactions, which can limit its solubility in water.
  • Common Solvents: N-ethyl-N-(o-tolyl)but-2-enamide is likely to be more soluble in organic solvents such as ethanol, acetone, or chloroform compared to water.

In practical terms, one might observe the following general behavior:

  1. If dissolved in water, the solubility may be quite low.
  2. In alcohol-based solvents, it is expected to show adequate solubility due to the preferential interactions with the polar functional groups.
  3. Non-polar solvents may also dissolve this compound effectively due to the hydrophobic nature of its alkyl chains.

Overall, understanding the solubility of N-ethyl-N-(o-tolyl)but-2-enamide is vital for its application in various chemical processes, making it an important consideration in both laboratory and industrial settings.

Interesting facts

Interesting Facts about N-ethyl-N-(o-tolyl)but-2-enamide

N-ethyl-N-(o-tolyl)but-2-enamide, also known for its unique structure and functional groups, is a fascinating compound in the realm of organic chemistry. Here are some noteworthy points:

  • Diverse Applications: This compound is often explored for its potential in pharmaceutical research. Its structure may lead to novel properties that can be harnessed in drug development.
  • Synthetic Pathways: The synthesis of N-ethyl-N-(o-tolyl)but-2-enamide involves intricate reactions, allowing chemists to utilize various methods including Condensation and Michael addition reactions. This synthesis can often serve as an educational example for students learning about reaction mechanisms.
  • Structure-Activity Relationship: Due to its unique arrangement of functional groups, this compound provides an excellent case study for analyzing how small changes in molecular structure can significantly affect biological activity and reactivity.
  • Analyzing Steric Effects: The presence of the ethyl and o-tolyl groups makes it interesting from a steric perspective. Studying how these substituents influence the compound's reactivity is a valuable exercise in understanding steric hindrance.
  • Research Importance: N-ethyl-N-(o-tolyl)but-2-enamide is sometimes studied for its potential implications in agrochemicals, hinting at its role outside of traditional medicine.

Overall, the exploration of N-ethyl-N-(o-tolyl)but-2-enamide not only aids in advancing chemical understanding but also inspires future research avenues, making it an exciting compound for both students and experienced chemists alike.

Synonyms
Crotan
DTXSID6040664
CHEBI:31439
N-ethyl-N-(2-methylphenyl)but-2-enamide
Crotamiton (Cis/Trans Mixture)
Crotaglin
N-ethylcrotono-o-toluidide
D6S4O4XD0H
Crotamiton; N-Ethyl-N-(2-methylphenyl)but-2-enamide
DTXCID4020664
Prestwick0_000951
Prestwick1_000951
Spectrum2_001700
Spectrum3_001081
Spectrum4_001234
CROTAMITON (MART.)
NCIOpen2_004405
KBioGR_001728
SPBio_001660
SPBio_003091
CHEMBL3183440
CROTAMITON (EP IMPURITY)
KBio3_001942
CROTAMITON (EP MONOGRAPH)
CROTAMITON (USP IMPURITY)
DNTGGZPQPQTDQF-UHFFFAOYSA-N
CROTAMITON (USP MONOGRAPH)
HMS3369O11
HMS3393E10
AKOS028108434
DB00265
NCGC00094571-07
NCGC00248176-01
DB-051546
207-596-3