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N-formylformamide

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Identification
Molecular formula
C2H3NO2
CAS number
630-18-2
IUPAC name
N-formylformamide
State
State

Liqiud at room temperature.

Melting point (Celsius)
3.00
Melting point (Kelvin)
276.15
Boiling point (Celsius)
194.00
Boiling point (Kelvin)
467.15
General information
Molecular weight
73.07g/mol
Molar mass
73.0670g/mol
Density
1.2484g/cm3
Appearence

N-formylformamide is a colorless liquid. It is known for being somewhat viscous and generally clear in appearence.

Comment on solubility

Solubility of N-formylformamide

N-formylformamide, with the chemical formula H2NCHO, exhibits interesting solubility characteristics that are noteworthy for various applications in chemistry. This compound is known to be:

  • Highly soluble in polar solvents such as water and methanol, making it accessible for reactions that require a soluble medium.
  • Soluble in a variety of organic solvents, further enhancing its versatility in organic synthesis and laboratory settings.
  • Least soluble in non-polar solvents, which reflects the significance of polarity in determining solubility behavior.

Generally, the ability of N-formylformamide to dissolve in polar solvents can be attributed to its functional groups, which engage in hydrogen bonding and dipole-dipole interactions with solvent molecules. As scientists often say, “Like dissolves like,” indicating that compounds with similar polarity tend to mix well together.

Furthermore, the solubility of N-formylformamide is influenced by temperature; increasing the temperature enhances its solubility in water, enabling a more efficient use in synthetic processes. This unique solubility profile enables N-formylformamide to act as a solvent or a reagent in various chemical reactions, underscoring its importance in the field of organic chemistry.

Interesting facts

Interesting Facts About N-formylformamide

N-formylformamide is a fascinating chemical compound that plays a crucial role in various applications and chemical processes. Here are some intriguing insights into this compound:

  • Intermediate in Synthesis: N-formylformamide is often used as an important intermediate in the synthesis of other organic compounds. Its unique structure allows it to participate in numerous chemical reactions, making it valuable in organic chemistry.
  • Use in Pharmaceuticals: The compound is notably utilized in pharmaceutical chemistry. Its derivatives can lead to the development of significant bioactive molecules and potential drug candidates.
  • Formamide Analog: As a formamide derivative, N-formylformamide shares properties with formamide, making it useful in biological studies, particularly in understanding protein folding and the function of nucleic acids.
  • Solvent Properties: It serves as a solvent in various chemical reactions, owing to its polar characteristics, which can dissolve a wide range of substances.
  • Potential Environmental Concerns: Like many organic compounds, N-formylformamide may have environmental implications. Understanding its behavior in biological and environmental systems is vital for safeguarding ecological health.

As a compound encompassing both application and study potential, N-formylformamide continues to intrigue chemists and researchers alike. Its versatility highlights the interconnectedness of various fields within chemistry.

"In chemistry, there is no such thing as a simple compound; every molecule tells a story of complexity and potential."

Synonyms
N-Formylformimidic acid
N-Formylformamide
Diformylamine
Iminoaldehyde
18197-22-3
FORMAMIDE, N-FORMYL-
Diformamide
Formimidol
Formaldehyde, iminobis-
BRN 1736856
Allopurinol impurity 30
N-hydroxy methylene formamide
1-02-00-00022 (Beilstein Handbook Reference)
SCHEMBL129371
SCHEMBL129372
SCHEMBL181599
SCHEMBL1539042
SCHEMBL5251281
SCHEMBL7984307
DTXSID80171222
AKOS006279605