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1-Naphthylacetohydroxamic acid

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Identification
Molecular formula
C12H11NO2
CAS number
2994-83-0
IUPAC name
N-hydroxy-N-(2-naphthyl)acetamide
State
State

Solid at room temperature.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
392.00
Boiling point (Kelvin)
665.15
General information
Molecular weight
201.22g/mol
Molar mass
201.2220g/mol
Density
1.3200g/cm3
Appearence

White to off-white crystalline powder.

Comment on solubility

Solubility of N-hydroxy-N-(2-naphthyl)acetamide

N-hydroxy-N-(2-naphthyl)acetamide, often referred to as NHOA, exhibits interesting solubility characteristics that can be attributed to its molecular structure.

Solubility in Various Solvents

Its solubility can be analyzed in terms of different solvents:

  • Aqueous Solubility: NHOA demonstrates limited solubility in water due to the hydrophobic nature of the naphthyl group.
  • Organic Solvent Solubility: It is more soluble in organic solvents such as ethanol, acetone, and chloroform. This behavior is typical for compounds with aromatic rings, allowing for better interactions with non-polar solvents.
  • pH Dependence: The solubility can also vary with changes in pH; in more basic conditions, the compound may ionize, potentially increasing its solubility in aqueous solutions.

Factors Influencing Solubility

Several factors can influence the solubility of N-hydroxy-N-(2-naphthyl)acetamide:

  • Temperature: Generally, an increase in temperature can enhance the solubility of solids in liquids.
  • Presence of Co-Solvents: The use of co-solvents may improve the solubility profile by creating a more favorable environment for dissolution.
  • Hydrogen Bonding: The hydroxyl functional group can participate in hydrogen bonding, affecting its interaction with solvent molecules.

In summary, N-hydroxy-N-(2-naphthyl)acetamide's solubility is a complex interplay of its chemical structure and environmental conditions, showcasing the principle that *"like dissolves like."* Understanding these solubility characteristics is crucial for its applications in various chemical processes.

Interesting facts

Interesting Facts About N-hydroxy-N-(2-naphthyl)acetamide

N-hydroxy-N-(2-naphthyl)acetamide is a fascinating compound primarily known for its applications in various scientific fields. Here are some intriguing aspects of this compound:

  • Biological Activity: This compound has been studied for its potential biological activities, including anti-inflammatory and anticancer properties. Researchers are exploring its mechanisms of action and how it interacts with cellular pathways.
  • Pharmacological Significance: N-hydroxy-N-(2-naphthyl)acetamide is of interest in medicinal chemistry, potentially serving as a lead compound for drug development. Its unique structure may contribute to desirable pharmacological effects.
  • Intermediary Role: It can act as an intermediary in the synthesis of other complex organic compounds. This makes it valuable in the realm of organic synthesis, particularly in academic research laboratories.
  • Structure-Activity Relationship: Scientists often study the structure-activity relationship (SAR) of this compound to understand how modifications to its structure can enhance its efficacy or reduce toxicity.
  • Chemical Stability: One of the interesting aspects of N-hydroxy-N-(2-naphthyl)acetamide is its chemical stability under various conditions, making it suitable for various laboratory applications.

As an **organic chemist** or a **student of chemistry**, one might find it exciting to delve into the experimental techniques used to synthesize this compound and evaluate its properties. As the field of medicinal chemistry continues to evolve, compounds like N-hydroxy-N-(2-naphthyl)acetamide could play a crucial role in developing novel therapeutic agents.

In conclusion, N-hydroxy-N-(2-naphthyl)acetamide not only captivates with its chemical properties but also inspires further research into its capabilities and applications. As we advance in our understanding of chemistry, compounds of this nature provide endless opportunities for discovery and innovation.

Synonyms
N-Hydroxy-N-2-naphthalenylacetamide
2-(N-Hydroxyacetamido)naphthalene
CCRIS 3359
UNII-7RG4E395IV
N-Hydroxy-N-acetyl-2-aminonaphthalene
BRN 2725217
N-Hydroxy-N-(2-naphthyl)acetamide
Acetohydroxamic acid, N-2-naphthyl-
DTXSID50179770
N-OH-AAN
DTXCID10102261
ypsgswzvngyaol-uhfffaoysa-n
N-Hydroxy-2-acetylaminonaphthalene
2508-23-8
N-Acetyl-N-hydroxy-2-aminonaphthalene
N-2-Naphthylacetohydroxamic acid
N-Acetyl-2-naphthylhydroxylamine
Acetamide, N-hydroxy-N-2-naphthalenyl-
7RG4E395IV
ACETOHYDROXAMIC ACID, N-(2-NAPHTHYL)-
N-Hydroxy-N-(2-naphthyl)acetamide #
Q27268752