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N-Hydroxy-N-methylacetamide

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Identification
Molecular formula
C3H7NO2
CAS number
7784-77-6
IUPAC name
N-hydroxy-N-methyl-acetamide
State
State

At room temperature, N-hydroxy-N-methylacetamide exists as a solid. It may exhibit a crystalline structure or appear as a fine powder.

Melting point (Celsius)
50.00
Melting point (Kelvin)
323.15
Boiling point (Celsius)
149.00
Boiling point (Kelvin)
422.15
General information
Molecular weight
89.10g/mol
Molar mass
89.1050g/mol
Density
1.1200g/cm3
Appearence

N-Hydroxy-N-methylacetamide is typically a solid at room temperature. It may appear as a crystalline solid or as a powder, depending on its exact form and purity. The substance is often colorless or white.

Comment on solubility

Solubility of N-hydroxy-N-methyl-acetamide

N-hydroxy-N-methyl-acetamide is known for its favorable solubility characteristics, particularly in polar solvents. Here are some key points to consider regarding its solubility:

  • Polar Solvents: It is highly soluble in water, which can be attributed to its ability to form hydrogen bonds due to the presence of both a hydroxyl group (-OH) and an amide group (-C(=O)N-).
  • Solvent Compatibility: In addition to water, N-hydroxy-N-methyl-acetamide shows good solubility in various alcohols and dimethyl sulfoxide (DMSO), making it versatile for multiple applications in laboratory settings.
  • Temperature Dependency: Its solubility can vary with temperature; typically, increasing temperature enhances solubility in polar solvents.

Moreover, it is important to note that low solubility in non-polar solvents limits its use in applications requiring such media. Overall, the solubility profile of N-hydroxy-N-methyl-acetamide supports its use in biochemical and synthetic chemistry as a reagent and solvent.

Interesting facts

Interesting Facts about N-hydroxy-N-methyl-acetamide

N-hydroxy-N-methyl-acetamide is a fascinating compound that has garnered attention for its unique properties and applications in the field of chemistry. Here are some intriguing points:

  • Versatile function: This compound is often used as a reagent in organic synthesis, serving as an efficient source of hydroxylamine.
  • Pharmaceutical significance: Its ability to act as a metabolic precursor makes it a subject of interest in drug development and medicinal chemistry.
  • Mechanistic exploration: N-hydroxy derivatives, including this compound, are crucial for understanding various chemical reactions, particularly nucleophilic attack mechanisms.
  • Environmental impact: Research into its environmental toxicity is ongoing, as derivatives of hydroxamic acids can influence biological systems.
  • Historical context: Compounds similar to N-hydroxy-N-methyl-acetamide have been studied since the mid-20th century, marking a notable evolution in organic chemical research.

“N-hydroxy compounds serve as important intermediates in various chemical transformations.” This quote encapsulates the role of N-hydroxy-N-methyl-acetamide in expanding our understanding of organic synthesis.

Given its structural characteristics and functionality, N-hydroxy-N-methyl-acetamide continues to be a subject of intense study, demonstrating the complexities and wonders found within organic chemistry.

Synonyms
N-Hydroxy-N-methylacetamide
Acetamide, N-hydroxy-N-methyl-
N-Methylacetohydroxamic acid
N-Methyl acetohydroxamic acid
N-Acetyl-N-methylhydroxylamine
ACETOHYDROXAMIC ACID, N-METHYL-
NMAH acid
NSC 329234
7BXE337G7T
AI3-61934
NSC-329234
N-METHYL-N-ACETYLHYDROXYLAMINE
Acetamide, N-hydroxy-N-methyl-(9CI)
13115-24-7
Acetamide,N-hydroxy-N-methyl-
NoName_1668
UNII-7BXE337G7T
SCHEMBL863004
SCHEMBL4327012
SCHEMBL5014563
CHEMBL4761573
DTXSID10902425
NSC329234
AKOS006273714
DS-009632
EN300-261005