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Isoniazid

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Identification
Molecular formula
C6H7N3O
CAS number
54-85-3
IUPAC name
N-(hydroxymethyl)pyridine-4-carboxamide
State
State

In its standard form, isoniazid is typically a solid at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
171.00
Melting point (Kelvin)
444.20
Boiling point (Celsius)
260.50
Boiling point (Kelvin)
533.70
General information
Molecular weight
137.14g/mol
Molar mass
137.1400g/mol
Density
1.4040g/cm3
Appearence

Isoniazid is a white to off-white crystalline powder. It is odorless to practically odorless and is hydrophilic in nature.

Comment on solubility

Solubility of N-(hydroxymethyl)pyridine-4-carboxamide

N-(hydroxymethyl)pyridine-4-carboxamide, often abbreviated as HMPA, exhibits intriguing solubility characteristics that make it a notable compound in various chemical contexts. Here are some key points regarding its solubility:

  • Solubility in Water: HMPA is generally soluble in water, which makes it advantageous for applications in aqueous environments.
  • Solvents: In addition to water, HMPA is soluble in polar organic solvents such as methanol and ethanol, enhancing its versatility in different formulations.
  • Temperature Effects: The solubility of HMPA can vary with temperature; typically, increased temperatures can lead to enhanced solubility.
  • pH Influence: The solubility may also be affected by the pH of the solution, given the presence of both a carboxamide and a hydroxymethyl group.

In conclusion, N-(hydroxymethyl)pyridine-4-carboxamide serves as a prime example of a compound with favorable solubility properties that can be adjusted according to varying conditions. Its ability to dissolve in both water and polar organic solvents underscores its significant role in chemical synthesis and research.

Interesting facts

Interesting Facts about N-(hydroxymethyl)pyridine-4-carboxamide

N-(hydroxymethyl)pyridine-4-carboxamide is a fascinating compound that blends the characteristics of both pyridine and amide functional groups. Here are some engaging aspects of this compound:

  • Structural Complexity: The presence of the hydroxymethyl and carboxamide groups on the pyridine ring results in a compound with unique reactivity patterns and potential biological activity.
  • Biological Significance: Compounds like N-(hydroxymethyl)pyridine-4-carboxamide may exhibit antimicrobial and anti-inflammatory properties, making them of interest in pharmaceutical research. Scientists are continuously exploring their potential as drug candidates.
  • Versatile Applications: This compound might serve as an intermediate in organic synthesis, particularly in the development of other heterocyclic compounds. Its reactivity can be harnessed to create more complex molecules.
  • Research Interest: Ongoing studies in medicinal chemistry often focus on derivatives of pyridine compounds, including this one, due to their varied and significant applications in drug discovery and development.

As a student or scientist, the study of such compounds expands one's understanding of pharmaceutical chemistry and underlines the importance of functional group interactions in designing effective therapies. The synthesis and exploration of N-(hydroxymethyl)pyridine-4-carboxamide can lead to innovative solutions in medicine.

In summary, N-(hydroxymethyl)pyridine-4-carboxamide is more than just a compound; it embodies the synthesis of chemistry and biochemistry, opening doors for future discoveries!

Synonyms
ISONICOTINAMIDE, N-(HYDROXYMETHYL)-
N-(Hydroxymethyl)isonicotinamide
13538-44-8
QV15BV5BQ3
NSC 120640
BRN 0129518
4-Pyridinecarboxamide, N-(hydroxymethyl)-
UNII-QV15BV5BQ3
NSC-120640
DTXSID20159327
4-22-00-00534 (Beilstein Handbook Reference)
N-(HYDROXYMETHYL)-4-PYRIDINECARBOXAMIDE
DTXCID8081818
4-Pyridinecarboxamide, N-(hydroxymethyl)-(9CI)
N-(hydroxymethyl)pyridine-4-carboxamide
NSC120640
N-hydroxymethylisonicotinamide
SCHEMBL7273110
SCHEMBL10917308
AKOS002685606
DS-002003